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Phytogalactolipids activate humoral immunity against colorectal cancer
BackgroundColorectal cancer (CRC) is the third most lethal cancer in the world, and its incidence is steadily rising. In this study, we investigated...
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Cytokine Autoantibodies Are Associated with Infection Risk and Self-Perceived Health: Results from the Danish Blood Donor Study
The presence of naturally occurring cytokine-specific autoantibodies (c-aAb) in humans is well established, as well as associations to selected...
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The Beneficial Clinical Effects of Teriflunomide in Experimental Autoimmune Myasthenia Gravis and the Investigation of the Possible Immunological Mechanisms
Myasthenia gravis (MG) is an autoantibody-mediated autoimmune disease characterized by skeletal muscle weakness exacerbated with exercise. There is a...
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Neuroimmune Mechanisms of Cerebellar Ataxias
This chapter discusses cell- and autoantibody-mediated immune mechanisms impairing cerebellar neurons and circuits. Various autoimmune processes...
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COVID-19 and Autoimmunity
Coronavirus disease 2019 (COVID-19), caused by the continuously evolving novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has been...
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Enhancement of NETosis by ACE2-cross-reactive anti-SARS-CoV-2 RBD antibodies in patients with COVID-19
BackgroundHigh levels of neutrophil extracellular trap (NET) formation or NETosis and autoantibodies are related to poor prognosis and disease...
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B cells in autoimmune hepatitis: bystanders or central players?
B cells are central for the adaptive immune system to mount successful immune responses not only as antibody producers but also as regulators of...
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Bispecific T cell engager therapy for refractory rheumatoid arthritis
Bispecific T cell engagers (BiTEs) kill B cells by engaging T cells. BiTEs are highly effective in acute lymphoblastic leukemia. Here we treated six...
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The Effect of Inhaled Air Particulate Matter SRM 1648a on the Development of Mild Collagen-Induced Arthritis in DBA/J Mice
Air pollution is considered to be one of a risk factor for rheumatoid arthritis (RA). Collagen-induced arthritis (CIA) is commonly used as a mouse...
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Extracellular Vesicle Biomarkers for Immune Disorders
Abnormalities in the immune system can cause a range of autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and...
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Mechanisms of Immunological Toxicity in Cancer Immunotherapy with Checkpoint Inhibitors
The use of checkpoint inhibitors is revolutionizing the treatment outcomes in many cancer types. Besides this benefit, using checkpoint inhibitors...
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Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity
Glycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and...
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Therapeutic potential of exosomes derived from mesenchymal stem cells for treatment of systemic lupus erythematosus
Autoimmune diseases are caused by an imbalance in the immune system, producing autoantibodies that cause inflammation leading to tissue damage and...
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Anti-rheumatoid arthritis potential of Halodule pinifolia: development, characterization and in vivo evaluation of H. pinifolia-based oral suspension and lipid nano-emulsion
For treating chronic diseases like rheumatoid arthritis, herbal medicines are preferred due to their evident therapeutic effects and lesser side...
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Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a life-threatening autoimmune disease characterized by adaptive immune system activation, formation of...
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Immunopathogenesis of urticaria: a clinical perspective on histamine and cytokine involvement
BackgroundUrticaria is a clinical condition characterized by the appearance of wheals (hives), angioedema, or both. Over the last several decades, a...
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Lymphocyte-Directed Immunomodulation Remits Thymoma-Associated Autoimmune Pneumonitis
BackgroundThymoma presents with several autoimmune manifestations and is associated with secondary autoimmune regulator (AIRE) deficiency....
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Anti-AQP4 autoantibodies promote ATP release from astrocytes and induce mechanical pain in rats
BackgroundIntractable neuropathic pain is a common symptom of neuromyelitis optica spectrum disorder (NMOSD). However, the underlying mechanism of...
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Clinical and Immunological Features of SARS-CoV-2 Breakthrough Infections in Vaccinated Individuals Requiring Hospitalization
Background and PurposeWaning immunity and the surge of SARS-CoV-2 variants are responsible for breakthrough infections, i.e., infections in fully...
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The potential roles of Th17 cells in the pathogenesis of oral lichen planus
BackgroundOral lichen planus (OLP) is a T cell-mediated chronic autoimmune disease, whose pathogenesis and etiology are not entirely understood. OLP...
