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Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
Damage of the endothelial glycocalyx (eGC) plays a central role in the development of vascular hyperpermeability and organ damage during systemic...
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Theaflavin mitigates acute gouty peritonitis and septic organ injury in mice by suppressing NLRP3 inflammasome assembly
Activation of NLR family pyrin domain-containing 3 (NLRP3) inflammasome plays important role in defending against infections, but its aberrant...
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Antimicrobial activity and mechanism of anti-MRSA of phloroglucinol derivatives
BackgroundIn previous studies, authors have completed the total synthesis of several phloroglucinol natural products and synthesized a series of...
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Designer Microbes: Oncotherapy Approach
New treatment regimens in targeted anti-cancer therapy and recent immunotherapeutic advances for the same have revolutionized the management of the...
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Extracellular CIRP dysregulates macrophage bacterial phagocytosis in sepsis
In sepsis, macrophage bacterial phagocytosis is impaired, but the mechanism is not well elucidated. Extracellular cold-inducible RNA-binding protein...
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EGFR of platelet regulates macrophage activation and bacterial phagocytosis function
BackgroundBeyond their crucial role in hemostasis, platelets possess the ability to regulate inflammation and combat infections through various...
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Chronic hyperglycemia impairs anti-microbial function of macrophages in response to Mycobacterium tuberculosis infection
Diabetes mellitus (DM) is a major risk factor for tuberculosis (TB), though the underlying mechanisms linking DM and TB remain ambiguous. Macrophages...
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Recent Update on Bacteria as a Delivery Carrier in Cancer Therapy: From Evil to Allies
Cancer is associated with a comprehensive burden that significantly affects patient’s quality of life. Even though patients’ disease condition is...
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How Artificial Intelligence Is Transforming the Prevalence and Prevention of Neuroinfectious Disease?
Artificial intelligence is currently revolutionizing the field of medicine. This technological advancement has the ability to serve multiple purposes...
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Salivary microbiome changes distinguish response to chemoradiotherapy in patients with oral cancer
BackgroundOral squamous cell carcinoma (SCC) is associated with oral microbial dysbiosis. In this unique study, we compared pre- to post-treatment...
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Membrane lipid remodeling eradicates Helicobacter pylori by manipulating the cholesteryl 6'-acylglucoside biosynthesis
BackgroundHelicobacter pylori , the main cause of various gastric diseases, infects approximately half of the human population. This pathogen is...
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Gut Microbiome: A Key Factor in Ageing and an Aim for Anti-senescence Intervention
The ageing process is increasingly being attributed to the gut microbiome. It has been hypothesized that age-related gut dysbiosis is influenced by...
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Plant Secondary Metabolites Physico-Chemical Properties and Therapeutic Applications
Plant secondary metabolites are plant-based natural products that display a variety of pharmacological effects. This book discusses the invaluable...
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Monophosphoryl lipid A as a co-adjuvant in methicillin-resistant Staphylococcus aureus vaccine development: improvement of immune responses in a mouse model of infection
To increase the effectiveness of methicillin-resistant Staphylococcus aureus vaccines (MRSA), a new generation of immune system stimulating adjuvants...
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Bacterial Lysate Complex Administered Intranasally Suppresses Inflammation in an In Vivo Model of Aseptic Lymphadenitis
The effect of a bacterial lysate complex IRS 19 on local and systemic manifestations of inflammation was studied in a rat model of aseptic...
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Saccharomyces cerevisiae β-glucan improves the response of trained macrophages to severe P. aeruginosa infections
Objective P. Aeruginosa(PA), the major pathogen of lung cystic fibrosis (CF), polarizes macrophages into hyperinflammatory tissue damaging phenotype....
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PTSD, Immune System, and Inflammation
Posttraumatic stress disorder (PTSD) is a severe trauma and stress-related disorder associated with different somatic comorbidities, especially...
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Unravelling the pharmacological properties of cryptolepine and its derivatives: a mini-review insight
Cryptolepine (1,5-methyl-10 H -indolo[3,2- b ]quinoline), an indoloquinoline alkaloid, found in the roots of Cryptolepis sanguinolenta (Lindl.) Schltr...
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Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases
Chemokines belong to the family of cytokines with chemoattractant properties that regulate chemotaxis and leukocyte migration, as well as the...
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Synthesis and evaluation of novel 3, 4-dihydropyrimidin-2(1H)- thione based pongamol conjugates as antibacterial agents
Pongamol, the furanochalcone present in different parts of karanj ( Pongamia glabra ) tree has been taken in this investigation to undergo Biginelli...
