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Comparative anatomy on the development of sperm transporting pathway between the testis and mesonephros
The male genital tract is diverse among vertebrates, but its development remains unclear, especially in the rete region. In this study, we...
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Down Syndrome
Down syndrome (DS) is the most commonly identified genetic form of mental retardation and the leading cause of specific birth defects and medical...
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Premature ovarian insufficiency: pathogenesis and therapeutic potential of mesenchymal stem cell
Primary ovarian insufficiency (POI) is defined as a reduction in ovarian function before the expected age of menopause. POI is known to increase the...
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Leukocyte telomere length in children born following blastocyst-stage embryo transfer
Perinatal and childhood adverse outcomes associated with assisted reproductive technology (ART) has been reported, but it remains unknown whether the...
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A re-appraisal of mesenchymal-epithelial transition (MET) in endometrial epithelial remodeling
Mesenchymal-epithelial transition (MET) is a mechanism of endometrial epithelial regeneration. It is also implicated in adenocarcinoma and...
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The Roles of Stress-Induced Immune Response in Female Reproduction
Stress response plays pivotal roles in physiological process, including reproduction and embryonic development. It’s long been acknowledged that...
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Biomedical Science and Women’s Health
Health is a universal right. It is the duty of every nation to take care of its women and girls as their health is the health of population. There...
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Sexual Differentiation of the Brain and Behavior: A Primer
A general theory of sexual differentiation of the brain derives from classic experiments performed in the twentieth century, which determined that...
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Melatonin and multiple sclerosis: antioxidant, anti-inflammatory and immunomodulator mechanism of action
BackgroundMelatonin is an indole hormone secreted primarily by the pineal gland that showing anti-oxidant, anti-inflammatory and anti-apoptotic...
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Delineation of an inverted tandem Xq23-26.3 duplication in a female featuring extremely short stature and mild mental deficiency
BackgroundPartial duplications involving the long arm of the X chromosome are associated with mental retardation, short stature, microcephaly, and a...
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Association between cumulative cisplatin dose and reproductive and sexual functions in patients with malignant ovarian germ cell tumors treated with bleomycin, etoposide, and cisplatin therapy: a case series study
BackgroundThe impact of cumulative dose of cisplatin on gonadal function has not been clarified. We evaluated whether the cumulative cisplatin dose...
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Effects of chromosomal translocation characteristics on fertilization and blastocyst development — a retrospective cohort study
ObjectiveTo determine the effect of different translocation characteristics on fertilization rate and blastocyst development in chromosomal...
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Short-chain fatty acid-butyric acid ameliorates granulosa cells inflammation through regulating METTL3-mediated N6-methyladenosine modification of FOSL2 in polycystic ovarian syndrome
Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder characterized by chronic low-grade inflammation. Previous studies have...
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Effect of early postnatal exposure to 17α-ethinylestradiol on female rat reproductive physiology
Objective17α-Ethinylestradiol (EE2) is a synthetic compound used as an oral contraceptive in birth control pills. EE2 is a major contaminant in...
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Hormones Regulating Sex Development
Testosterone, the primary hormone required for sexual differentiation, is synthesised by a complex pathway from cholesterol. Variants in genes...
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Natural and Experimental Sex Reversal in Birds and Other Groups of Vertebrates, with the Exception of Mammals
AbstractThe review is focused on the current problem of sex determination. Many research papers were devoted to this issue, but all the details of...
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Transcription factor EB-mediated autophagy affects cell migration and inhibits apoptosis to promote endometriosis
Autophagy has emerged as an important process of cell metabolism. With continuous in-depth research on autophagy, TFEB has been a key transcription...
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Breast cancer risk prediction in women aged 35–50 years: impact of including sex hormone concentrations in the Gail model
BackgroundModels that accurately predict risk of breast cancer are needed to help younger women make decisions about when to begin screening....
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Towards improved genetic diagnosis of human differences of sex development
Despite being collectively among the most frequent congenital developmental conditions worldwide, differences of sex development (DSD) lack...
