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In Situ Measurement of Intra-tumoral Tissue Rigidity
Local tissue scale mechanical properties are essential for understanding cell fate and function; however, few methods to measure stiffness at this...
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Neoantigen-targeted TCR-engineered T cell immunotherapy: current advances and challenges
Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising approach for cancer therapy with an expectation of no...
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Functionalized Lipidic Nanoparticles: Smartly Engineered Lipidic Theragnostic Nanomedicines
The concept of theranostics revolutionized with the inception of surface engineering of nanolipidic carriers. In the modern era of precision...
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Small molecule–engineered nanoassembly for lipid peroxidation–amplified photodynamic therapy
Photodynamic therapy (PDT), extensively explored as a non-invasive and spatio-temporal therapeutic modality for cancer treatment, encounters...
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Exploring the interaction between extracellular matrix components in a 3D organoid disease model to replicate the pathophysiology of breast cancer
In vitro models are necessary to study the pathophysiology of the disease and the development of effective, tailored treatment methods owing to the...
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Tissue Engineering and Regenerative Medicine in Cancer Therapy
With all the progress in cancer biology and treatment, the pathophysiology of the cancer is still not thoroughly known, and its treatments are...
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An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration
During bone regeneration, the periosteum acts as a carrier for key regenerative cues, delivering osteochondroprogenitor cells and crucial growth...
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Genetically engineered mesenchymal stem cells with dopamine synthesis for Parkinson’s disease in animal models
Although striatal delivery of three critical genes for dopamine synthesis by viruses is a potential clinical approach for treating Parkinson’s...
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Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models
This contributed volume reviews the latest advances on relevant 3D tissue engineered in vitro models of disease making use of biomaterials and...
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Utilization of 3D printing technology in hepatopancreatobiliary surgery
The technology of three-dimensional (3D) printing emerged in the late 1970s and has since undergone considerable development to find numerous...
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New Solutions for Old Problems: How Reproductive Tissue Engineering Has Been Revolutionizing Reproductive Medicine
Acquired disorders and congenital defects of the male and female reproductive systems can have profound impacts on patients, causing sexual and...
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Biomaterials and scaffolds for tissue engineering and regenerative medicine
Methods in tissue engineering and regenerative medicine are constantly evolving to address the complex challenges of repairing damaged tissues and...
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3D-to-4D Structures: an Exploration in Biomedical Applications
3D printing is a cutting-edge technique for manufacturing pharmaceutical drugs (Spritam), polypills (guaifenesin), nanosuspension (folic acid), and...
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3D Bioprinting of Human Hollow Organs
3D bioprinting is a rapidly evolving technique that has been found to have extensive applications in disease research, tissue engineering, and...
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Pirfenidone affects human cardiac fibroblast proliferation and cell cycle activity in 2D cultures and engineered connective tissues
The anti-fibrotic drug pirfenidone (PFD) is currently in clinical testing for the treatment of heart failure with preserved ejection fraction;...
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An engineered miRNA PS-OMe miR130 inhibits acute lung injury by targeting eCIRP in sepsis
BackgroundSepsis is caused by the dysregulated immune response due to an initial infection and results in significant morbidity and mortality in...
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Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury
BackgroundAcute lung injury (ALI) is a life-threatening respiratory condition characterized by severe inflammation and lung tissue damage, frequently...
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Development and Characterization of Heparin-Containing Hydrogel/3D-Printed Scaffold Composites for Craniofacial Reconstruction
Regeneration of cartilage and bone tissues remains challenging in tissue engineering due to their complex structures, and the need for both...
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Harnessing 3D in vitro systems to model immune responses to solid tumours: a step towards improving and creating personalized immunotherapies
In vitro 3D models are advanced biological tools that have been established to overcome the shortcomings of oversimplified 2D cultures and mouse...
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Mechanobiology of Collective Cell Migration in 3D Microenvironments
Tumor cells invade individually or in groups, mediated by mechanical interactions between cells and their surrounding matrix. These multicellular...