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Eph receptors and ephrins in cancer progression
Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together make up the ‘Eph system’) in cancer development and...
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A cell cycle centric view of tumour dormancy
Tumour dormancy and recurrent metastatic cancer remain the greatest clinical challenge for cancer patients. Dormant tumour cells can evade treatment...
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A timeline of tumour-associated macrophage biology
Tumour progression is modulated by the local microenvironment. This environment is populated by many immune cells, of which macrophages are among the...
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Transfer RNAs as dynamic and critical regulators of cancer progression
Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode the genetic code into proteins. Recent work has uncovered...
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Immunoproteasome inhibition prevents progression of castration-resistant prostate cancer
BackgroundCastration-resistant prostate cancer (CRPC) is refractory to hormone treatment. This study aims to explore the effect and underlying...
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Cancer stem cell–immune cell crosstalk in tumour progression
Cellular heterogeneity and an immunosuppressive tumour microenvironment are independent yet synergistic drivers of tumour progression and underlie...
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Therapeutic targeting of tumour myeloid cells
Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The accumulation of tumour-modified myeloid cells derived from...
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Single-cell sequencing of PIT1-positive pituitary adenoma highlights the pro-tumour microenvironment mediated by IFN-γ-induced tumour-associated fibroblasts remodelling
BackgroundPIT1-positive pituitary adenoma (PIT1-PA) is one of the most important lineages of pituitary adenoma (PA), which causes systematic...
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LINC00629 protects osteosarcoma cell from ER stress-induced apoptosis and facilitates tumour progression by elevating KLF4 stability
BackgroundEsca** from ER stress-induced apoptosis plays an important role in the progression of many tumours. However, its molecular mechanism in...
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USP30 promotes the progression of breast cancer by stabilising Snail
Breast cancer (BC) is the most prevalent tumour in women worldwide. USP30 is a deubiquitinase that has been previously reported to promote tumour...
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HVEM in acute lymphocytic leukemia facilitates tumour immune escape by inhibiting CD8+ T cell function
PurposeLeukaemia remains a major contributor to global mortality, representing a significant health risk for a substantial number of cancer patients....
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The prognostic and biology of tumour-infiltrating lymphocytes in the immunotherapy of cancer
Tumour immunotherapy has achieved remarkable clinical success in many different types of cancer in the past two decades. The outcome of immune...
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Higher platelet counts correlate to tumour progression and can be induced by intratumoural stroma in non-metastatic breast carcinomas
BackgroundPlatelets support tumour progression. However, their prognostic significance and relation to circulating tumour cells (CTCs) in operable...
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Tumour cell-derived serglycin promotes IL-8 secretion of CAFs in gastric cancer
BackgroundCancer-associated fibroblasts (CAFs)-derived IL-8 plays important roles in chemoresistance, immunosuppression, and lymph node metastasis of...
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Involvement of redox signalling in tumour cell dormancy and metastasis
Decades of research on oncogene-driven carcinogenesis and gene-expression regulatory networks only started to unveil the complexity of tumour...
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HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1
BackgroundCastration-resistant prostate cancer (CRPC) is refractory to hormone treatment, and the underlying mechanism has not been fully elucidated....
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Circulating Tumour Cell Isolation and Molecular Profiling; Potential Therapeutic Intervention
Comprehensive tumour characterisation is indispensable for patients to receive targeted therapy. The use of liquid biopsy, particularly circulating...
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Progress of single-cell RNA sequencing combined with spatial transcriptomics in tumour microenvironment and treatment of pancreatic cancer
In recent years, single-cell analyses have revealed the heterogeneity of the tumour microenvironment (TME) at the genomic, transcriptomic, and...
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PARD3 drives tumorigenesis through activating Sonic Hedgehog signalling in tumour-initiating cells in liver cancer
BackgroundPar-3 Family Cell Polarity Regulator (PARD3) is a cellular protein essential for asymmetric cell division and polarized growth. This study...
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Bacteria in cancer initiation, promotion and progression
Cancer cells originate from a series of acquired genetic mutations that can drive their uncontrolled cell proliferation and immune evasion....
