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Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock
BackgroundPolynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow) possesses superoxide dismutase/catalase mimetic activities that may directly...
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Nrf1 Knock-Down in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Intervention of Superoxide Production-Removal Balance and Mitochondrial Function
Oxidative stress in the hypothalamic paraventricular nucleus (PVN) contributes greatly to the development of hypertension. The recombinant nuclear...
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Protective Effects of Glatiramer Acetate Against Paclitaxel-Induced Peripheral Neuropathy in Rats: A Role for Inflammatory Cytokines and Oxidative Stress
Chemotherapy-induced peripheral neuropathy (CIPN) is a major challenge for cancer patients who undergo chemotherapy with paclitaxel. Therefore,...
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Method for Collection of Tear Fluid for Evaluation Its Antioxidant Properties
A technique of collection of the tear fluid with Schirmer strips for evaluation of the activity of the main antioxidant defense enzymes (superoxide...
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Antioxidant Status of Rat Liver Mitochondria under Conditions of Moderate Hypothermia of Different Duration
For evaluation of the contribution of the antioxidant system of mitochondria into the dynamics of changes in the prooxidant status, the content and...
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Indicators of LPO and Antioxidant Protection in Rats During Long-Term Restriction of Motor Activity
This article presents a comprehensive study of the parameters of LPO (concentrations of malondialdehyde, diene conjugates, and intensity of...
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D-Ribose-L-Cysteine and L-Dopa Co-Supplementation Attenuates Paraquat-Induced Oxidative Damage and Locomotion Deficit in Drosophila melanogaster
AbstractD-ribose L-cysteine is a glutathione precursor that acts as an antioxidant. In the present study, we investigated the effect of D-ribose...
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Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for playing a dual role, since they can be either deleterious...
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Parameters of Oxidative Stress and Activity of Antioxidant Enzymes in the Saliva of Patients with Type 1 Diabetes Mellitus
Glucose concentration in the saliva is increased in type 1 diabetes mellitus. This parameter directly correlates with markers of the disease in the...
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The Role of Calcium in Implementation of the Effect of Brassinosteroids during the Induction of Oxidative Stress in Tobacco
Brassinosteroids are plant hormones that play an important role in the regulation of the growth, development, and stress responses in plants,...
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Prolactin is an Endogenous Antioxidant Factor in Astrocytes That Limits Oxidative Stress-Induced Astrocytic Cell Death via the STAT3/NRF2 Signaling Pathway
Oxidative stress-induced death of neurons and astrocytes contributes to the pathogenesis of numerous neurodegenerative diseases. While significant...
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Silencing KPNA2 Promotes Ferroptosis in Laryngeal Cancer by Activating the FoxO Signaling Pathway
AbstractWe aim to clarify the specific role of Karyopherin α2 (KPNA2) in the progression of laryngeal cancer, a kind of malignant tumor with a poor...
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Modulation of glutathione S-transferase and superoxide dismutase in response to heavy metals in brackish water flea Diaphanosoma celebensis
ObjectivesSuperoxide dismutase (SOD) and glutathione S -transferase (GST) serve as biomarkers of oxidative stress in aquatic organisms. However, the...
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The complete genome sequence of the lumpy skin disease virus vaccine Herbivac LS reveals a mutation in the superoxide dismutase gene homolog
The lumpy skin disease virus (LSDV) vaccine, Herbivac LS, batch 008, was sequenced and found to differ from the Neethling vaccine strain in the locus...
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A new recombinant MS-superoxide dismutase alleviates 5-fluorouracil-induced intestinal mucositis in mice
Intestinal mucositis is a common side effect of anticancer regimens that exerts a negative impact on chemotherapy. Superoxide dismutase (SOD) is a...
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Oxidative Stress, Diabetic Retinopathy, and Superoxide Dismutase 3
Diabetic retinopathy (DR) is a multifaceted disease, combining the deleterious effects of hyperglycemia and the propensity for accumulation of...
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TGFB1, FOXO1, and COMP Genes Expression in Blood of Patients with Osteoarthritis after SARS-CoV2 Infection
Abstract —Nowadays the possible influence of the coronavirus infection on cartilage degeneration and synovial membrane inflammation during chronic...
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Evaluation of dexamethasone and its combination with mineral supplements on the DNA compactness/breakage and the efficiency of antioxidant defense enzymes
ObjectiveDexamethasone, a synthetic glucocorticoid drug, is widely used as an anti-inflammatory/anti-allergic agent worldwide. Several previous...
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Influence of High-Carbohydrate and High-Lipid Diet on the Enzymatic Link of Antioxidant Protection and the Level of Oxidatively Modified Proteins and Lipids in Rat Erythrocytes
The influence of a high-lipid and high-carbohydrate diet, as inducers of the development of metabolic syndrome on the prooxidant-antioxidant state of...
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Evaluating Motor Dysfunction and Oxidative Stress Induced by Trichloroethylene in Wistar Rats
Trichloroethylene, a chlorinated solvent widely used as a degreasing agent, is a common environmental contaminant. Emerging evidence suggests that...