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Lecture 2: Review of Chemistry
Most matter is usually “impure”, being a mixture of variable amounts of several different substances.
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Flow Chemistry as an Enabling Technology for Synthetic Organic Chemistry
Continuous-flow processing is proving to be an enabling technology for synthetic organic chemists. After an introduction to the advantages and...
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Small molecule inhibitors against PD-1/PD-L1 immune checkpoints and current methodologies for their development: a review
Programmed death-1/programmed death ligand-1 (PD-1/PD-L1) based immunotherapy is a revolutionary cancer therapy with great clinical success. The...
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A Study of Small Molecule-Based Rhodamine-Derived Chemosensors and their Implications in Environmental and Biological Systems from 2012 to 2021: Latest Advancement and Future Prospects
Rhodamine-based chemosensors have sparked considerable interest in recent years due to their remarkable photophysical properties, which include high...
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Chemistry and Function of Glycosaminoglycans in the Nervous System
Proteoglycans, and especially their GAG components, participate in numerous biologically significant interactions with growth factors, chemokines,...
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Single-molecule methylation profiles of cell-free DNA in cancer with nanopore sequencing
Epigenetic characterization of cell-free DNA (cfDNA) is an emerging approach for detecting and characterizing diseases such as cancer. We developed a...
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An Ontology to Describe Small Molecule Pharmaceutical Product Development and Methodology for Optimal Activity Scheduling
PurposeThis contribution is the first example of a small molecule pharmaceutical product development ontology. This ontology allows the...
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Subcellular Drug Depots as Reservoirs for Small-Molecule Drugs
Therapeutic nanoparticles (TNP) have been developed to more efficiently and safely deliver medicines, especially for the treatment of solid cancers....
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Anti-brain Aging Effects of Small Molecule Inhibitor DDQ
The purpose of our study is to determine the protective effects of the newly discovered molecule DDQ (diethyl...
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Most large structural variants in cancer genomes can be detected without long reads
Short-read sequencing is the workhorse of cancer genomics yet is thought to miss many structural variants (SVs), particularly large chromosomal...
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Computational Chemistry and Molecular Modeling of Reversible MAO Inhibitors
Proper elucidation of drug-target interaction is one of the most significant steps at the early stages of the drug development research....
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Stability and Characterization of Protein- and Nucleotide-Based Therapeutics
Throughout the development process of protein or nucleotide-based therapeutics, a broad array of analytical techniques is applied on a routine basis...
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Advances in Ultra-small Fluorescence Nanoprobes for Detection of Metal Ions, Drugs, Pesticides and Biomarkers
Identification of trace level chemical species (drugs, pesticides, metal ions and biomarkers) plays key role in environmental monitoring. Recently,...
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Alzheimer’s disease: using gene/protein network machine learning for molecule discovery in olive oil
Alzheimer’s disease (AD) poses a profound human, social, and economic burden. Previous studies suggest that extra virgin olive oil (EVOO) may be...
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Upregulation of wild-type p53 by small molecule-induced elevation of NQO1 in non-small cell lung cancer cells
The tumor suppressor p53 is usually inactivated by somatic mutations in malignant neoplasms, and its reactivation represents an attractive...
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Synthesis, Self-Assembly, and Functional Chemistry of Amphiphilic Block Copolymers
The polymeric micelles are the colloidal nanostructures composed of amphiphilic copolymers (having two functional blocks, namely hydrophobic and...
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Free Radical Chemistry of Carotenoids and Oxidative Stress Physiology of Cancer
The role of carotenoids on reducing vitamin A deficiency and cardiovascular and age-related degenerative diseases has been addressed in the last...
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Free Radical Chemistry of Carotenoids and Oxidative Stress Physiology of Cancer
The role of carotenoids on reducing vitamin A deficiency and cardiovascular and age-related degenerative diseases has been addressed in the last...
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Modulation of cellular transcriptome and proteome composition by azidohomoalanine—implications on click chemistry–based secretome analysis
AbstractThe analysis of the secretome provides important information on proteins defining intercellular communication and the recruitment and...
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The expanding role for small molecules in immuno-oncology
The advent of immune checkpoint inhibition (ICI) using antibodies against PD1 and its ligand PDL1 has prompted substantial efforts to develop...
