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Regulatory mechanism of LncRNAs in gonadal differentiation of hermaphroditic fish, Monopterus albus
BackgroundMonopterus albus is a hermaphroditic fish with sex reversal from ovaries to testes via the ovotestes in the process of gonadal...
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Spatial transcriptomics reveal basal sex differences in supraoptic nucleus gene expression of adult rats related to cell signaling and ribosomal pathways
BackgroundThe supraoptic nucleus (SON) of the hypothalamus contains magnocellular neurosecretory cells that secrete the hormones vasopressin and...
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Sex differences in neurobehavioral consequences of methamphetamine exposure in adult mice
RationaleRecreational and medical use of stimulants is increasing, and their use may increase susceptibility to aging and promote neurobehavioral...
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Sex-related differences in left ventricular remodeling and outcome after alcohol septal ablation in hypertrophic obstructive cardiomyopathy: insights from cardiovascular magnetic resonance imaging
BackgroundAlcohol septal ablation (ASA) has been proven to reverse left ventricular (LV) remodeling in hypertrophic cardiomyopathy (HCM). However,...
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Sex Differences in Pulmonary Arterial Hypertension
Under normal conditions, the pulmonary circulation is a low-resistance, low-pressure system. Pulmonary hypertension (PH) is a heterogeneous condition...
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Sex-dependent dynamics of metabolism in primary mouse hepatocytes
The liver is one of the most sexually dimorphic organs. The hepatic metabolic pathways that are subject to sexual dimorphism include xenobiotic,...
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Sex Differences in Cystic Fibrosis Across the Lifespan
Cystic fibrosis (CF) is an autosomal recessive multiorgan disease that is caused by mutations in a gene, cystic fibrosis transmembrane conductance...
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H3K27ac chromatin acetylation and gene expression analysis reveal sex- and situs-related differences in develo** chicken gonads
BackgroundBirds exhibit a unique asymmetry in terms of gonad development. The female left gonad generates a functional ovary, whereas the right gonad...
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The roles of sex and gender in women’s eye health disparities in the United States
BackgroundIn the United States, women are at a higher risk of develo** vision impairment or a serious eye disease (such as age-related macular...
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Integrated chromatin accessibility and DNA methylation analysis to reveal the critical epigenetic modification and regulatory mechanism in gonadal differentiation of the sequentially hermaphroditic fish, Monopterus albus
BackgroundMonopterus albus is a hermaphroditic and economically farmed fish that undergoes sex reversal from ovary to testis via ovotestis during...
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Towards improved genetic diagnosis of human differences of sex development
Despite being collectively among the most frequent congenital developmental conditions worldwide, differences of sex development (DSD) lack...
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Sex disparities matter in cancer development and therapy
Curing cancer through precision medicine is the paramount aim of the new wave of molecular and genomic therapies. Currently, whether patients with...
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Anatomically Aligned Loading During Falls: Influence of Fall Protocol, Sex and Trochanteric Soft Tissue Thickness
Fall simulations provide insight into skin-surface impact dynamics but have focused on vertical force magnitude. Loading direction and location...
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Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats
BackgroundSeveral chronic pain disorders, such as migraine and fibromyalgia, have an increased prevalence in the female population. The underlying...
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The intersection of stress, sex and immunity in fishes
While sexual dimorphism in immune responses has been documented in other vertebrates, evidence for a similar phenomenon in fish is lacking. Here, we...
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Cognitive performance during adulthood in a rat model of neonatal diffuse white matter injury
RationaleInfants born prematurely risk develo** diffuse white matter injury (WMI), which is associated with impaired cognitive functioning and an...
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Sex differences in ventromedial hypothalamic nucleus glucoregulatory transmitter biomarker protein during recurring insulin-induced hypoglycemia
Recurring insulin-induced hypoglycemia (RIIH) in males correlates with maladaptive glucose counter-regulatory collapse and acclimated expression of...
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Sex differences in effort-related decision-making: role of dopamine D2 receptor antagonism
RationaleDepressed individuals demonstrate debilitating symptoms, including depressed mood, anhedonia, and effort-related deficits. Effort-related...
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Brain (Yakovlevian) torque direction is associated with volume asymmetry of the intracranial transverse sinuses: evidence from situs inversus totalis
Previous research reported reversal of the prototypical brain torque in individuals with mirrored visceral topology (situs inversus totalis, SIT)....
