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Role of Chemokines in the Development and Progression of Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurogenerative disorder manifested by gradual memory loss and cognitive decline due to profound damage of...
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Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy
BackgroundThe translocator protein (TSPO) has been identified as a positron emission tomography (PET)-visible biomarker of inflammation and promising...
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P62 accumulates through neuroanatomical circuits in response to tauopathy propagation
In Alzheimer’s disease and related tauopathies, trans-synaptic transfer and accumulation of pathological tau from donor to recipient neurons is...
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Muscarinic Receptor-Dependent Long Term Depression in the Perirhinal Cortex and Recognition Memory are Impaired in the rTg4510 Mouse Model of Tauopathy
Neurodegenerative diseases affecting cognitive dysfunction, such as Alzheimer’s disease and fronto-temporal dementia, are often associated...
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RETRACTED ARTICLE: Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology
The accumulation of neurofibrillary tangles (NFTs), which is composed of abnormally hyperphosphorylated tau aggregates, is the classic neuropathology...
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Correction to: Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia
In the original publication of this article [1], the funding acknowledgement for grant “ Alzheimer Society Research Program (ASRP) from the Alzheimer...
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Microglia in Alzheimer’s Disease: a Key Player in the Transition Between Homeostasis and Pathogenesis
Immune activation accompanies the development of proteinopathy in the brains of Alzheimer’s dementia patients. Evolving from the long-held viewpoint...
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TREM2 and microglia exosomes: a potential highway for pathological tau
Tau pathology appears to spread along neuronal networks via the template misfolding of tau by pathological tau conformations. The mechanisms...
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Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
BackgroundThe S209F variant of Abelson Interactor Protein 3 ( ABI3 ) increases risk for Alzheimer’s disease (AD), but little is known about its...
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Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy
Tauopathies, including Alzheimer’s disease, are characterized by retinal ganglion cell loss associated with amyloid and phosphorylated tau deposits....
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Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy
Tauopathies, including frontotemporal dementia (FTD) and Alzheimer’s disease (AD) are progressive neurodegenerative diseases clinically characterized...
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Tau induces PSD95–neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration
Cerebrovascular abnormalities have emerged as a preclinical manifestation of Alzheimer’s disease and frontotemporal dementia, diseases characterized...
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Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response
BackgroundTau stabilizes microtubules; however, in Alzheimer’s disease (AD) and tauopathies, tau becomes hyperphosphorylated, aggregates, and results...
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Tracking progressive pathological and functional decline in the rTg4510 mouse model of tauopathy
BackgroundThe choice and appropriate use of animal models in drug discovery for Alzheimer’s disease (AD) is pivotal to successful clinical...
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Synergy between amyloid-β and tau in Alzheimer’s disease
Patients with Alzheimer’s disease (AD) present with both extracellular amyloid-β (Aβ) plaques and intracellular tau-containing neurofibrillary...
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Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds
Recent studies suggest that misfolded tau molecules can be released, and taken up by adjacent neurons, propagating proteopathic seeds across neural...
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PBPK model for antibody disposition in mouse brain: validation using large-pore microdialysis data
The objective of this manuscript was to validate a physiologically-based pharmacokinetic (PBPK) model developed to characterize brain...
