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Microsomal prostaglandin E synthase 2 deficiency is resistant to acetaminophen-induced liver injury
Acetaminophen (APAP)-induced liver injury is the main cause of acute liver failure. This study investigated the role of microsomal prostaglandin E...
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Prostaglandin EP2 receptor antagonist ameliorates neuroinflammation in a two-hit mouse model of Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) causes substantial medical and societal burden with no therapies ameliorating cognitive deficits. Centralized...
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Syntenin-1 promotes colorectal cancer stem cell expansion and chemoresistance by regulating prostaglandin E2 receptor
BackgroundThe protein syntenin-1 is expressed by a variety of cell types, and is upregulated in various malignancies, including melanoma, breast...
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Vitamin E Exerts Neuroprotective Effects in Pentylenetetrazole Kindling Epilepsy via Suppression of Ferroptosis
Epilepsy is one of the most common chronic neurological diseases. There is increasing evidence for ferroptosis playing an important role in the...
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Prostaglandin E2 Increases Neurite Length and the Formation of Axonal Loops, and Regulates Cone Turning in Differentiating NE4C Cells Via PKA
Prostaglandin E2 (PGE2) is a membrane-derived lipid signaling molecule important in neuronal development. Abnormal levels of PGE2, due to...
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Compiling Evidence for EVALI: A Sco** Review of In Vivo Pulmonary Effects After Inhaling Vitamin E or Vitamin E Acetate
BackgroundVitamin E acetate (VEA) has come under significant scrutiny due to its association with E-cigarette or va** product use–associated lung...
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Attenuation of CFA-induced chronic inflammation by a bicyclic monoterpene fenchone targeting inducible nitric oxide, prostaglandins, C-reactive protein and urea
Fenchone (a bicyclic monoterpene) is present in the essential oils of plant species like Foeniculum vulgare and Peumus boldus and is used to treat...
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Prostaglandin E1 Improves Cerebral Microcirculation Through Activation of Endothelial NOS and GRPCH1
Endothelial dysfunction greatly contributes to microcirculation disorder. The role of prostaglandin E1 (PGE1) in cerebral microcirculation was...
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Cyclooxygenase-2 Induced the β-Amyloid Protein Deposition and Neuronal Apoptosis Via Upregulating the Synthesis of Prostaglandin E2 and 15-Deoxy-Δ12,14-prostaglandin J2
Elevated levels of cyclooxygenase-2 (COX-2) and prostaglandins (PGs) have been shown to be involved in the pathogenesis of Alzheimer’s disease....
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Crosstalk between P2Y receptors and cyclooxygenase activity in inflammation and tissue repair
The role of extracellular nucleotides as modulators of inflammation and cell stress is well established. One of the main actions of these molecules...
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The impact of E-cigarette va** and vapour constituents on bone health
BackgroundIn contrast to cigarettes, electronic cigarette use (E-cigarettes) has grown substantially over the last decade. This is due to their...
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Present State and Future Perspectives of Prostaglandins as a Differentiation Factor in Motor Neurons
Spinal motor neurons have the longest axons that innervate the skeletal muscles of the central nervous system. Motor neuron diseases caused by spinal...
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Vitamins (C, D and E) Against Cancer
Cancer is the leading cause of death worldwide. This disease is described as accelerated and uncontrolled cell multiplication. In recent decades,...
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Autocrine regulation of tumor cell repopulation by Hsp70-HMGB1 alarmin complex
BackgroundCancer recurrence is regulated by a variety of factors, among which is the material of dying tumor cells; it is suggested that remaining...
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The Ratio of Omega-6/Omega-3 Fatty Acid: Implications and Application as a Marker to Diabetes
Omega-3 and omega-6 groups of polyunsaturated fatty acids (PUFA) are non-interconvertible and metabolically and functionally different, with key...
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Metabolomics combined with network pharmacology reveals a role for astragaloside IV in inhibiting enterovirus 71 replication via PI3K-AKT signaling
BackgroundAstragaloside IV (AST-IV), as an effective active ingredient of Astragalus membranaceus (Fisch.) Bunge. It has been found that AST-IV...
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Oral administration of Jumihaidokuto inhibits UVB-induced skin damage and prostaglandin E2 production in HR-1 hairless mice
This study was conducted to investigate whether and how Jumihaidokuto (JHT), a traditional Chinese medicine, prevents UVB-induced skin damage in male...
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MSCs mediate long-term efficacy in a Crohn’s disease model by sustained anti-inflammatory macrophage programming via efferocytosis
Mesenchymal stem cells (MSCs) are novel therapeutics for the treatment of Crohn’s disease. However, their mechanism of action is unclear, especially...
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Reprogramming of arachidonate metabolism confers temozolomide resistance to glioblastoma through enhancing mitochondrial activity in fatty acid oxidation
BackgroundSp1 is involved in the recurrence of glioblastoma (GBM) due to the acquirement of resistance to temozolomide (TMZ). Particularly, the role...
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Study on peripheral antinociception induced by hydrogen peroxide (H2O2): characterization and mechanisms
The present study aimed to evaluate the possible peripheral H 2 O 2 -induced antinociception and determine the involvement of opioidergic,...
