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Showing 21-30 of 30 results

  1. RNA Nanotechnology Approach for Targeted Delivery of RNA Therapeutics Using Cell-Internalizing Aptamers

    The development of RNA-based therapeutics has progressed rapidly in recent years. RNA aptamers are a form of nanoparticles ranging in size from 10 to...
    Ka-To Shum, John J. Rossi in DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases
    Chapter 2013

  2. Aptamer-Mediated siRNA Targeting

    RNA interference (RNAi) is a sequence-specific mechanism for posttranscriptional inhibition of gene expression. As such, it is an attractive approach...
    Jiehua Zhou, John J. Rossi in RNA Interference from Biology to Therapeutics
    Chapter 2013

  3. Synthesis, Conjugation, and Labeling of Multifunctional pRNA Nanoparticles for Specific Delivery of siRNA, Drugs, and Other Therapeutics to Target Cells

    RNA is unique in nanoscale fabrication due to its amazing diversity of function and structure. RNA nanoparticles can be fabricated with a level of...
    Peixuan Guo, Yi Shu, ... Mathieu Cinier in Rational Drug Design
    Protocol 2012

  4. Application of Aptamers for Targeted Therapeutics

    Aptamers are short, single-stranded oligonucleotides that are isolated through a process termed systematic evolution of ligands by exponential...

    Partha Ray, Kristi D. Viles, ... Rebecca Smock Woodruff in Archivum Immunologiae et Therapiae Experimentalis
    Article 07 April 2013

  5. RNA Nanoparticles for Gene Expression Regulation

    In this chapter, we view the methodology of rational design, characterization and implementation of tecto-RNA nanoparticles for gene regulation....
    Roza Pawlowska, Paulina Gwozdzinska, Arkadiusz Chworos in DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases
    Chapter 2013

  6. Nucleic Acid-Based Encapsulations for Cancer Diagnostics and Drug Delivery

    With the advancements in proteomics, it is now known that molecular abnormalities found in cancerous cells stem mostly from the proteins involved in...
    Mohammed Arif I. Mahmood, Umair J. M. Khan, Samir M. Iqbal in DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases
    Chapter 2013

  7. Barriers to Non-Viral Vector-Mediated Gene Delivery in the Nervous System

    Efficient methods for cell line transfection are well described, but, for primary neurons, a high-yield method different from those relying on viral...

    Francisco C. Pérez-Martínez, Javier Guerra, ... Valentín Ceña in Pharmaceutical Research
    Article Open access 12 January 2011

  8. AIDS Treatment with Novel Anti-HIV Compounds Improved by Nanotechnology

    The first International Symposium of Nanomedicine on AIDS “AIDS Treatment with Novel Anti-HIV compounds Improved by Nanotechnology” was held November...

    **aowei Ma, Dongliang Wang, ... **ng-Jie Liang in The AAPS Journal
    Article 06 April 2010

  9. Nucleic Acids-Based Therapeutics in the Battle Against Pathogenic Viruses

    For almost three decades, researchers have studied the possibility to use nucleic acids as antiviral therapeutics. In theory, compounds such as...
    Joost Haasnoot, Ben Berkhout in Antiviral Strategies
    Chapter 2009

  10. Construction of folate-conjugated pRNA of bacteriophage phi29 DNA packaging motor for delivery of chimeric siRNA to nasopharyngeal carcinoma cells

    Nasopharyngeal carcinoma is a poorly differentiated upper respiratory tract cancer that highly expresses human folate receptors (hFR). Binding of...

    S Guo, F Huang, P Guo in Gene Therapy
    Article 16 February 2006
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