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Influence of Plasdone™ S630 Ultra—an Improved Copovidone on the Processability and Oxidative Degradation of Quetiapine Fumarate Amorphous Solid Dispersions Prepared via Hot-Melt Extrusion Technique
In a formulation, traces of peroxides in copovidone can impact the stability of drug substances that are prone to oxidation. The present study aimed...
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Solution-Based Dosage Forms and Sterile Products
This chapter expands upon the concept of drug solubility and dissolution as it relates to dosage form design. Excipients utilized in solution-based...
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Lacidipine Amorphous Solid Dispersion Based on Hot Melt Extrusion: Good Miscibility, Enhanced Dissolution, and Favorable Stability
The present study aimed to increase the in vitro dissolution rate of lacidipine, a poorly water-soluble drug, by formulating amorphous solid...
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Systematic Development of Hot Melt Extrusion-Based Amorphous Solid Dispersion: Integrating Quality by Design and In Silico Modeling
PurposeThe study aimed to develop and optimize apremilast (APST) solid dispersion formulations using copovidone (Kollidon VA64) as the carrier and...
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Implications of Low-concentration Polymer on the Physical Stability of Glassy Griseofulvin: Role of the Segmental Mobility
Crystallization of amorphous pharmaceutical solids are widely reported to be affected by the addition of polymer, while the underlying mechanism...
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Enhanced Solubility and Bioavailability of Dolutegravir by Solid Dispersion Method: In Vitro and In Vivo Evaluation—a Potential Approach for HIV Therapy
Being a candidate of BCS class II, dolutegravir (DTG), a recently approved antiretroviral drug, possesses solubility issues. The current research was...
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Multicomponent Amorphous Solid Forms of Telmisartan: Insights into Mechanochemical Activation and Physicochemical Attributes
The present work aims to explore the new solid forms of telmisartan (TEL) with alpha-ketoglutaric acid (KGA) and glutamic acid (GA) as potential...
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Effects of Additives on the Physical Stability and Dissolution of Polymeric Amorphous Solid Dispersions: a Review
Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the solubility of poorly water-soluble drugs. However, achieving both...
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Preparation and Evaluation of Siderol Amorphous Solid Dispersions: Selection of Suitable Matrix/Carrier
The present study investigates the preparation of amorphous solid dispersions (ASD) for the ent-kaurane diterpenoid siderol (SDR). Initially,...
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Development and preclinical assessment of nanoemulgel loaded with phytoconstituents for the management of rheumatoid arthritis
In recent years, natural ingredients have gained importance for therapeutic treatment due to their minimal toxicity. However, the delivery of these...
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Structured Development Approach for Amorphous Systems
A structured development approach is presented to guide the development of stable and commercially viable polymer-based amorphous formulations. The...
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Thermodynamic, Spatial and Methodological Considerations for the Manufacturing of Therapeutic Polymer Nanoparticles
PurposeEvaluate fundamental parameters that dictate the effectiveness of drug loading.
MethodsA model water-soluble drug lacking ionizable groups,...
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Preformulation of 3D Printable Pharmaceutical Dosage Forms
Preformulation studies are designed to ensure a pharmaceutical dosage form will be produced within the best scenario of materials and processing...
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High payload dexamethasone palmitate-loaded solid lipid nanoparticles for enhanced anti-inflammatory effects in acute skin inflammation model
PurposeDexamethasone palmitate (DXPL) is a lipophilic derivative of dexamethasone (DXM) used to overcome the low drug-loading capacity and immediate...
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A nanoemulsion/micelles mixed nanosystem for the oral administration of hydrophobically modified insulin
The potential of nanoemulsions for the oral administration of peptides is still in its early stage. The aim of the present work was to rationally...
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In Silico Screening as a Tool to Prepare Drug-Drug Cocrystals of Ibrutinib-Ketoconazole: a Strategy to Enhance Their Solubility Profiles and Oral Bioavailability
Ibrutinib (IBR) is a biopharmaceutical classification system (BCS) class II drug and an irreversible Bruton’s tyrosine kinase (BTK) inhibitor. IBR...
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Effect of Buffer Salts on Physical Stability of Lyophilized and Spray-Dried Protein Formulations Containing Bovine Serum Albumin and Trehalose
This study examined the effect of buffer salts on the physical stability of spray-dried and lyophilized formulations of a model protein, bovine serum...
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A Full Factorial Design to Optimize Aminexil Nano Lipid Formulation to Improve Skin Permeation and Efficacy Against Alopecia
Aminexil (AMX) is considered to be one of the most widely used hair growth promoters. Nanostructured lipid carriers (NLC) are employed to increase...
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Stability of Polymeric Micelles and Their Regulatory Status
Polymeric micelles (PMs) is an innovation approach toward advancement of nanodrug delivery systems. These PMs overcome the issues related to...
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Enhancing Solubility and Dissolution Behavior of Finasteride Using Solid Dispersion Technique by Carrier Screening and the New Preparation Instrument
PurposeThe purpose of this study was to improve the solubility and dissolution rate of finasteride (FIN) by searching for an optimal carrier to...
