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A novel intronic circular RNA circFGFR1int2 up-regulates FGFR1 by recruiting transcriptional activators P65/FUS and suppressing miR-4687-5p to promote prostate cancer progression
Fibroblast growth factor receptor 1 (FGFR1) is a core component of the FGFs/FGFR pathway that activates multiple signalling pathways, including...
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The interplay of miRNAs and ferroptosis in diseases related to iron overload
Ferroptosis has been conceptualized as a novel cell death modality distinct from apoptosis, necroptosis, pyroptosis and autophagic cell death. The...
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Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancer
Gastrointestinal cancer (GIC) is the most prevalent and highly metastatic malignant tumor and has a significant impact on mortality rates....
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Wnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer
Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic response of non-small cell lung cancer (NSCLC). In recent...
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Emerging roles of circular RNAs in gastric cancer metastasis and drug resistance
Gastric cancer (GC) is an aggressive malignancy with a high mortality rate and poor prognosis, primarily caused by metastatic lesions. Improved...
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Study of MicroRNA Cluster Located on Chromosome X in Serum and Breast Cancer Tissue
Breast cancer is a prevalent cancer type among women worldwide, with the second highest incidence rate. The objective of this study was to identify a...
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A review on the role of long non-coding RNA and microRNA network in clear cell renal cell carcinoma and its tumor microenvironment
Renal cell carcinoma (RCC) is the second lethal urogenital malignancy with the increasing incidence and mortality in the world. Clear cell renal cell...
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Targeting PI3K/Akt in Cerebral Ischemia Reperfusion Injury Alleviation: From Signaling Networks to Targeted Therapy
Ischemia/reperfusion (I/R) injury is a pathological event that results in reperfusion due to low blood flow to an organ. Cerebral ischemia is a...
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Emerging role of RNA modification and long noncoding RNA interaction in cancer
RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the occurrence and progression...
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Targeting NF-κB in Hepatic Ischemia–Reperfusion Alleviation: from Signaling Networks to Therapeutic Targeting
Hepatic ischemia–reperfusion injury (HIRI) is a major complication of liver trauma, resection, and transplantation that can lead to liver dysfunction...
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Progress in extracellular vesicle homeostasis as it relates to cardiovascular diseases
Extracellular vesicles (EVs) are involved in both physiological and pathological processes in many organ systems and are essential in mediating...
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Extracellular vesicles in cancer cachexia: deciphering pathogenic roles and exploring therapeutic horizons
Cancer cachexia (CC) is a debilitating syndrome that affects 50–80% of cancer patients, varying in incidence by cancer type and significantly...
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Key genes and molecular mechanisms related to Paclitaxel Resistance
Paclitaxel is commonly used to treat breast, ovarian, lung, esophageal, gastric, pancreatic cancer, and neck cancer cells. Cancer recurrence is...
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Identification of BACH1-IT2-miR-4786-Siglec-15 immune suppressive axis in bladder cancer
The sialic acid binding Ig like lectin 15 (Siglec-15) was previously identified as tumor immune suppressor gene in some human cancers with elusive...
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Circ_FNDC3B Promotes Cell Proliferation and Metastasis in Esophageal Squamous Cell Carcinoma via Regulating MAPK1 by Binding to miR-136-5p
A handful of circular RNAs (circRNAs) associated with cancer progression have been indicated in esophageal squamous cell carcinoma (ESCC). The...
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CVD phenoty** in oncologic disorders: cardio-miRNAs as a potential target to improve individual outcomes in revers cardio-oncology
With the increase of aging population and prevalence of obesity, the incidence of cardiovascular disease (CVD) and cancer has also presented an...
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The strict regulation of HIF-1α by non-coding RNAs: new insight towards proliferation, metastasis, and therapeutic resistance strategies
The hypoxic environment is prominently witnessed in most solid tumors and is associated with the promotion of cell proliferation,...
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The NF-κB Pathway: a Focus on Inflammatory Responses in Spinal Cord Injury
Spinal cord injury (SCI) is a type of central nervous system trauma that can lead to severe nerve injury. Inflammatory reaction after injury is an...
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Role of microRNA-363 during tumor progression and invasion
Recent progresses in diagnostic and therapeutic methods have significantly improved prognosis in cancer patients. However, cancer is still considered...
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Contribution of extracellular vesicles for the pathogenesis of retinal diseases: shedding light on blood-retinal barrier dysfunction
Retinal degenerative diseases, including diabetic retinopathy (DR) and age-related macular degeneration (AMD), loom as threats to vision, causing...
