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Dissecting cell fate dynamics in pediatric glioblastoma through the lens of complex systems and cellular cybernetics
Cancers are complex dynamic ecosystems. Reductionist approaches to science are inadequate in characterizing their self-organized patterns and...
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Modification of Müller Glial Cell Fate and Proliferation with the Use of Small Molecules
In recent years, reprogramming Müller glia by overexpressing Ascl1 and other transcription factors has shown promise for the regeneration of...
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Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation
BackgroundThe emerging concepts of fetal-like reprogramming following tissue injury have been well recognized as an important cue for resolving...
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Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells
Transposable elements (TEs) are parasitic DNA sequences accounting for over half of the human genome. Tight control of the repression and activation...
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RSK3 switches cell fate: from stress-induced senescence to malignant progression
BackgroundTGFβ induces several cell phenotypes including senescence, a stable cell cycle arrest accompanied by a secretory program, and...
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Cell fate determination and Hippo signaling pathway in preimplantation mouse embryo
First cell fate determination plays crucial roles in cell specification during early phases of embryonic development. Three classical concepts have...
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Ganglioside Microdomains on Cellular and Intracellular Membranes Regulate Neuronal Cell Fate Determination
Gangliosides are sialylated glycosphingolipids (GSLs) with essential but enigmatic functions in brain activities and neural stem cell (NSC)...
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Fate of micronuclei and micronucleated cells after treatment of HeLa cells with different genotoxic agents
Although micronuclei are well-known biomarkers of genotoxic damage, the biological consequences of micronucleus induction are only poorly understood....
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Hippo pathway in cell–cell communication: emerging roles in development and regeneration
The Hippo pathway is a central regulator of tissue growth that has been widely studied in mammalian organ development, regeneration, and cancer...
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Lineage tracking to reveal the fate of hematopoietic stem cells influenced by Flk2− multipotent progenitors after transplantation
After transplantation, hematopoietic stem cells (HSCs) sustain blood cell regeneration throughout the patient’s life. Recent studies suggest that...
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Single-cell multiomic analysis of thymocyte development reveals drivers of CD4+ T cell and CD8+ T cell lineage commitment
The development of CD4 + T cells and CD8 + T cells in the thymus is critical to adaptive immunity and is widely studied as a model of lineage...
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Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems
Cell fate progression of pluripotent progenitors is strictly regulated, resulting in high human cell diversity. Epigenetic modifications also...
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Stem Cell Differentiation Mediated by Biomaterials/Surfaces
Directing the differentiation of stem cells into a specific stromal lineage such as adipocyte, chondrocyte, fibroblast, myocyte, and osteoblast cell...
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ETV3 and ETV6 enable monocyte differentiation into dendritic cells by repressing macrophage fate commitment
In inflamed tissues, monocytes differentiate into macrophages (mo-Macs) or dendritic cells (mo-DCs). In chronic nonresolving inflammation, mo-DCs are...
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Map** the Fate of Hypoxic Cells Using an Irreversible Fluorescent Switch
Hypoxia has been reported to promote tumor progression and metastasis in murine models, and patients with hypoxic tumors have a worse prognosis....