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Portable x-ray fluorescence for bone lead measurement: Current approaches and future directions
Purpose of ReviewLegacy lead exposures persist as a widespread problem. Blood lead is traditionally used for lead exposure surveillance; however,...
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The bone–muscle connection in breast cancer: implications and therapeutic strategies to preserve musculoskeletal health
Breast cancer and its therapies frequently result in significant musculoskeletal morbidity. Skeletal complications include bone metastases, pain,...
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DKK-1 and Its Influences on Bone Destruction: A Comparative Study in Collagen-Induced Arthritis Mice and Rheumatoid Arthritis Patients
Dickkopf-1 (DKK-1) has been considered a master regulator of bone remodeling. As precursors of osteoclasts (OCs), myeloid-derived suppressor cells...
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Clinical spectrum of rare bone fragility disorders and response to bisphosphonate treatment: a retrospective study
Osteogenesis Imperfecta (OI) is a clinically and genetically heterogeneous group of diseases characterized by brittle bones. Though genetic mutations...
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Current application of dexamethasone-incorporated drug delivery systems for enhancing bone formation
BackgroundDexamethasone (DEX) is a well-known anti-inflammatory and immunosuppressive drug applied broadly as an osteoinductive agent in bone...
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The effect of disease-modifying antirheumatic drugs (DMARDs) on bone homeostasis in rheumatoid arthritis (RA) patients
The autoimmune disease known as rheumatoid arthritis (RA) has been linked to the deterioration of bone. Bone erosion is a hallmark of RA and is...
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Bone samples’ behavior in sunlight, IR light, and temperature increase with FEM simulation
Biological and environmental factors produce biochemical processes that modify the bone structure. A few studies have attempted to show the adverse...
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TSPAN18 facilitates bone metastasis of prostate cancer by protecting STIM1 from TRIM32-mediated ubiquitination
BackgroundBone metastasis is a principal cause of mortality in patients with prostate cancer (PCa). Increasing evidence indicates that high...
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Osteoporosis and Cellular Senescence in Bone
OsteoporosisOsteoporosis is a very common disorder among the elderly. As society continues to age, the socioeconomic burden associated with...
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Bone-Muscle Crosstalk in Advanced Cancer and Chemotherapy
Advanced cancers metastasize to distant sites and bone is a common site for metastases from breast, lung, and prostate cancers. Breast and lung...
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Molecular Mechanisms of Metastasis to the Bone
Bone metastasis is an incurable and lethal aspect of many advanced-stage malignancies that significantly impacts patient quality of life. Although it...
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Mechanical stimuli-mediated modulation of bone cell function—implications for bone remodeling and angiogenesis
Bone remodeling, expressed as bone formation and turnover, is a complex and dynamic process closely related to its form and function. Different...
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Sex differences in the effects of repeated ketamine infusions on bone markers in patients with unipolar and bipolar depression
BackgroundPatients with depression, especially women, are associated with low bone mineral density (BMD). Traditional antidepressants are associated...
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Association between obstructive sleep apnea and low bone mass in adults: a systematic review and meta-analysis
IntroductionThis study aimed to synthesize existing evidence on the potential association between obstructive sleep apnea (OSA) and low bone mass in...
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Monocyte alteration in elderly hip fracture healing: monocyte promising role in bone regeneration
Individual aged with various change in cell and cellular microenvironments and the skeletal system undergoes physiological changes that affect the...
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A biomarker perspective on the acute effect of exercise with and without impact on joint tissue turnover: an exploratory randomized cross-over study
PurposeTo investigate acute changes in biochemical markers of bone and cartilage turnover in response to moderate intensity exercise with and without...
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The distribution of cellular turnover in the human body
We integrated ubiquity, mass and lifespan of all major cell types to achieve a comprehensive quantitative description of cellular turnover. We found...
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Ano5 modulates calcium signaling during bone homeostasis in gnathodiaphyseal dysplasia
ANO5 encodes transmembrane protein 16E (TMEM16E), an intracellular calcium-activated chloride channel in the endoplasmic reticulum. Mutations in ANO5 ...
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Differential expression of the inflammatory ciita gene may be accompanied by altered bone properties in intact sex steroid-deficient female rats
ObjectiveThe class II transactivator (CIITA), encoded by the CIITA gene, controls expression of immune response regulators, which affect bone...
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Co-regulation of circadian clock genes and microRNAs in bone metabolism
Mammalian bone is constantly metabolized from the embryonic stage, and the maintenance of bone health depends on the dynamic balance between bone...