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Body mass index stratification optimizes polygenic prediction of type 2 diabetes in cross-biobank analyses
Type 2 diabetes (T2D) shows heterogeneous body mass index (BMI) sensitivity. Here, we performed stratification based on BMI to optimize predictions...
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Body mass index and two-year change of in vivo Alzheimer’s disease pathologies in cognitively normal older adults
BackgroundLow body mass index (BMI) or underweight status in late life is associated with an increased risk of dementia or Alzheimer’s disease (AD)....
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An atlas of genome-wide gene expression and metabolite associations and possible mediation effects towards body mass index
AbstractInvestigating the cross talk of different omics layers is crucial to understand molecular pathomechanisms of metabolic diseases like obesity....
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Alcohol consumption and cancer incidence in women: interaction with smoking, body mass index and menopausal hormone therapy
BackgroundAlcohol consumption has been associated with increased risks of certain site-specific cancers and decreased risks of some other cancers....
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Long-term effects of aromatase inhibitors on body mass index among postmenopausal breast cancer survivors in Africa: observational cohort study
Purposethis study was conducted to assess the impact of AIs on body mass index and high sensitivity as prognostic predictors to be incorporated into...
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Effects of Body Mass and Age on the Pharmacokinetics of Subcutaneous or Hyaluronidase-facilitated Subcutaneous Immunoglobulin G in Primary Immunodeficiency Diseases
PurposeTo assess the pharmacokinetics (PK) of subcutaneous immunoglobulin (SCIG) and hyaluronidase-facilitated SCIG (fSCIG) therapy across body mass...
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A microbial causal mediation analytic tool for health disparity and applications in body mass index
BackgroundEmerging evidence suggests the potential mediating role of microbiome in health disparities. However, no analytic framework can be directly...
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Identification of novel genes whose expression in adipose tissue affects body fat mass and distribution: an RNA-Seq and Mendelian Randomization study
Many studies have shown that abdominal adiposity is more strongly related to health risks than peripheral adiposity. However, the underlying pathways...
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Body mass index–based predictions and personalized clinical strategies for colorectal cancer in the context of PPPM
Currently colorectal cancer (CRC) is the third most prevalent cancer worldwide. Body mass index (BMI) is frequently used in CRC screening and risk...
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Disentangling the aetiological pathways between body mass index and site-specific cancer risk using tissue-partitioned Mendelian randomisation
BackgroundBody mass index (BMI) is known to influence the risk of various site-specific cancers, however, dissecting which subcomponents of this...
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Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium
BackgroundObesity disproportionately affects African American (AA) women and has been shown to increase ovarian cancer risk, with some suggestions...
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Body mass index and additional risk factors for cancer in adults with cystic fibrosis
BackgroundAdults with cystic fibrosis (CF) have an increased risk of a variety of cancers, notably gastrointestinal cancers. In CF higher body mass...
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Effect of rapid weight loss incorporating hot salt water immersion on changes in body mass, blood markers, and indices of performance in male mixed martial arts athletes
PurposeTo investigate the effects of rapid weight loss (RWL), incorporating comparison of hot water immersion (HWI) in fresh or salt water, on...
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Impact of body mass index in therapeutic response for HER2 positive breast cancer treated with neoadjuvant targeted therapy: a multi-center study and meta-analysis
While overweight/obesity has become a major public health issue worldwide, any association between body mass index (BMI) and therapeutic response in...
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Chemotherapy dose per kilogram lean body mass increased dose-limiting toxicity event in male head and neck cancer with taxane and platinum-based induction therapy
BackgroundThis study aimed to determine whether drug doses per kilogram of lean body mass (LBM) were associated with dose-limiting toxicity (DLT)...
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RNA modification-related variants in genomic loci associated with body mass index
BackgroundGenome-wide association studies (GWASs) have identified hundreds of loci for body mass index (BMI), but functional variants in these loci...
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Body mass index and incidence of lung cancer in the HUNT study: using observational and Mendelian randomization approaches
BackgroundTraditional observational studies have shown an inverse association between body mass index (BMI) and lung cancer risk. Mendelian...
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Higher body mass index was associated with better prognosis in diabetic patients with stage II colorectal cancer
PurposeThe purpose of this study is to analyze the effect of body mass index (BMI) on patients with concurrent colorectal cancer (CRC) and type 2...
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Associations of combined physical activity and body mass index groups with colorectal cancer survival outcomes
BackgroundPhysical activity and BMI have been individually associated with cancer survivorship but have not yet been studied in combinations in...
