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Comprehensive analysis of coagulation indices for predicting survival in patients with biliary tract cancer
BackgroundAbnormal activation of the coagulation system has been reported in patients with malignancies, but its prognostic significance in biliary...
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Hepatitis B and C virus infections and the risk of biliary tract cancers: a meta-analysis of observational studies
BackgroundBoth hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are important risk factors for hepatocellular carcinoma. However, their...
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A phase II/III randomized clinical trial of CisPlatin plUs Gemcitabine and Nabpaclitaxel (GAP) as pReoperative chemotherapy versus immediate resection in patIents with resecTable BiliarY Tract Cancers (BTC) at high risk for recurrence: PURITY study
BackgroundBiliary tract cancers (BTCs) are rare and lethal cancers, with a 5-year survival inferior to 20%(1–3). The only potential curative...
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Spatiotemporal analysis of tumour-infiltrating immune cells in biliary carcinogenesis
BackgroundIntraductal papillary neoplasms (IPN) and biliary epithelial neoplasia (BilIN) are well‐defined precursor lesions of biliary tract...
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Relationship between elevated bilirubin levels and enhanced warfarin effects during biliary obstruction
ObjectivesA marked prolongation of the prothrombin time-international normalized ratio (PT-INR) is frequently observed during biliary obstruction in...
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Establishment and drug screening of patient-derived extrahepatic biliary tract carcinoma organoids
BackgroundPatient-derived organoids (PDO) have been proposed as a novel in vitro method of drug screening for different types of cancer. However, to...
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The efficacy and safety of apatinib treatment for patients with advanced or recurrent biliary tract cancer: a retrospective study
IntroductionThe present study aims to evaluate the efficacy and safety of apatinib monotherapy or combination therapy for patients with advanced or...
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Immunotherapy for Gastrointestinal Malignancies
Gastrointestinal (GI) malignancies comprise esophageal, stomach, liver, biliary tract, pancreatic, small bowel, appendiceal, colorectal, and anal...
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Phase 2 study of lenvatinib monotherapy as second-line treatment in unresectable biliary tract cancer: primary analysis results
BackgroundBiliary tract cancer (BTC) has a poor prognosis and lacks a standardized second-line therapy. Vascular endothelial growth factor (VEGF),...
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Oligo-metastatic neoPlasms from the gastro-intestinal tract: iDentIfiCaTIon of cliNical and molecular drivers: the PREDICTION study
BackgroundMetastatic disease in tumors originating from the gastrointestinal tract can exhibit varying degrees of tumor burden at presentation. Some...
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Hematologic traits and primary biliary cholangitis: a Mendelian randomization study
Hematologic abnormalities was observationally associated with the susceptibility of primary biliary cholangitis (PBC). However, the conclusion is...
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Suppressive myeloid cells are expanded by biliary tract cancer-derived cytokines in vitro and associate with aggressive disease
BackgroundBTC is an aggressive disease exacerbated by inflammation and immune suppression. Expansion of immunosuppressive cells occurs in biliary...
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A prospective feasibility study of one-year administration of adjuvant S-1 therapy for resected biliary tract cancer in a multi-institutional trial (Tokyo Study Group for Biliary Cancer: TOSBIC01)
BackgroundAlthough surgery is the definitive curative treatment for biliary tract cancer (BTC), outcomes after surgery alone have not been...
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Interleukin-8 produced from cancer-associated fibroblasts suppresses proliferation of the OCUCh-LM1 cancer cell line
BackgroundCancer-associated fibroblasts (CAFs) play an important role in cancer growth by interacting with cancer cells, but their effects differ...
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Introduction to Cancer Treatment
Cancer is defined as the outrageous growth of cells in a part of the body. It is one of the most common causes of death and its burden is on the rise...
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Study protocol of an open-label, single arm phase II trial investigating the efficacy and safety of Trifluridine/Tipiracil combined with irinotecan as a second line therapy in patients with cholangiocarcinoma (TRITICC)
BackgroundThe prognosis of patients with advanced biliary tract cancer (BTC) who have progressed on gemcitabine plus cisplatin is dismal....
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A retrospective study of patient-tailored FOLFIRINOX as a first-line chemotherapy for patients with advanced biliary tract cancer
BackgroundFOLFIRINOX is a pillar first-line regimen in the treatment of pancreatic cancer. Historically, biliary tract cancer (BTC) and pancreatic...
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The Role of Gut Microbiota in Gastrointestinal Tract Cancers
Disturbances in gastrointestinal (GI) microbiota could play a significant role in the development of GI cancers, but the underlying mechanisms remain...
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Synbiotics: Promising Approach for the Therapeutic Management of Cancer
Cancer represents a wide range of diseases that could begin in any parts of the body when cells grow abnormally and uncontrollably exceeding their...