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Investigation of Serum Albumin Conformational Changes in Melancholic Depression under Pharmacotherapy Using Subnanosecond Fluorescent Spectroscopy
AbstractThe aim of the study was to investigate the serum albumin conformation in patients with melancholic depression. There were investigated 22...
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Albumin therapy for hepatic encephalopathy: current evidence and controversies
Hepatic encephalopathy (HE) is a common complication that occurs in 16–21% of end-stage cirrhosis patients. Emerging evidence suggests that systemic...
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Impact of perioperative decreased serum albumin level on anastomotic leakage in esophageal squamous cell carcinoma patients treated with neoadjuvant chemotherapy followed by minimally invasive esophagectomy
BackgroundAnastomotic leakage (AL) is a severe complication following esophagectomy with high mortality. Perioperative decreased serum albumin level...
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Hydrolytic Metabolism of Withangulatin A Mediated by Serum Albumin Instead of Common Esterases in Plasma
Background and ObjectivesThe oral bioavailability of withangulatin A (WA) is low and may undergo first-pass metabolism because of the presence of two...
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Human Serum Albumin-enriched Clopidogrel Bisulfate Nanoparticle Alleviates Cerebral Ischemia–Reperfusion Injury in Rats
PurposeCerebral ischemia – reperfusion (I/R) injury remains a leading cause of mobility and mortality among patients with ischemic stroke. This study...
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Young and undamaged recombinant albumin alleviates T2DM by improving hepatic glycolysis through EGFR and protecting islet β cells in mice
BackgroundAlbumin is the most abundant protein in serum and serves as a transporter of free fatty acids (FFA) in blood vessels. In type 2 diabetes...
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Exploring the synergistic behavior of paclitaxel and vorinostat upon co-loading in albumin nanoparticles for breast cancer management
Breast cancer is challenging to treat accompanied with poor clinical outcomes. Paclitaxel (PTX) is a first-line chemotherapeutic agent, but possesses...
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Impacts of PAH accumulation on reproductive hormones, indices of oxidative stress and BPDE-albumin adduct in women with recurrent pregnancy loss
Chronic exposure to Poly aromatic hydrocarbons (PAHs) may be associated with adverse pregnancy outcomes. Disruption of hormonal and redox balance by...
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Evidence of nerve agent VX exposure in rat plasma by detection of albumin-adducts in vitro and in vivo
VX is a highly toxic organophosphorus nerve agent that reacts with a variety of endogenous proteins such as serum albumin under formation of adducts...
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Prognostic significance of preoperative lymphocytes, albumin, and neutrophils (LANR) index in resectable pancreatic ductal adenocarcinoma
PurposeThe index composed of preoperative lymphocytes, albumin, and neutrophils (LANR), a new composite score based on inflammatory response and...
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The Role of Impulsive and Aggressive Traits, Albumin and Thyroid Functions in Recent Suicide Attempters: An Investigation with a Transdiagnostic Approach
AbstractSuicide is a complex behavior involving multiple psychological and biological factors. However, multidimensional and transdiagnostic...
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Targeting unfolded protein response using albumin-encapsulated nanoparticles attenuates temozolomide resistance in glioblastoma
BackgroundChemoresistant cancer cells frequently exhibit a state of chronically activated endoplasmic reticulum (ER) stress. Engaged with ER stress,...
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Evaluation of CSF albumin quotient in neuronal surface antibody-associated autoimmune encephalitis
Background and ObjectivesDisruption of brain barriers is considered to be involved in the pathogenesis of neuronal surface antibody-associated...
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Ciprofloxacin HCl-loaded Albumin Nanoparticles for the Treatment of Recurrent Urinary Tract Infections: Preparation, Optimization, and Evaluation of Antibacterial Activity
PurposeThe present research aimed to describe a novel ciprofloxacin HCl-loaded bovine serum albumin nanoparticle formulation to improve the...
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Mucus-penetrating and permeation enhancer albumin-based nanoparticles for oral delivery of macromolecules: Application to bevacizumab
The oral administration of therapeutic proteins copes with important challenges (mainly degradation and poor absorption) making their potential...
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A Novel Thermal-driven Self-assembly Method to Prepare Albumin Nanoparticles: Formation Kinetics, Degradation Behavior and Formation Mechanism
Nanoparticles based on bovine serum albumin (BSA), which shares 76% homology with human serum albumin (HSA), have emerged as a promising candidate...
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Albumin alleviated esketamine-induced neuronal apoptosis of rat retina through downregulation of Zn2+-dependent matrix metalloproteinase 9 during the early development
AimsEsketamine upregulates Zn 2+ -dependent matrix metalloproteinase 9 (MMP9) and increases the neuronal apoptosis in retinal ganglion cell layer...
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Prognostic significance of hemoglobin, albumin, lymphocyte, and platelet (HALP) score in breast cancer: a propensity score-matching study
BackgroundThe hemoglobin-albumin-lymphocyte-platelet (HALP) score functions as a comprehensive index that assesses the systemic inflammatory...
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Topically-applied collagen-binding serum albumin-fused interleukin-4 modulates wound microenvironment in non-healing wounds
Non-healing wounds have a negative impact on quality of life and account for many cases of amputation and even early death among patients. Diabetic...
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The Role of Glycated Albumin as a Biomarker of Glycemic Control in Diabetes and Chronic Kidney Disease
Albumin is the most abundant protein found in plasma and constitutes approximately 60% of all proteins in the blood. This high molecular weight...