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The DOCK protein family in vascular development and disease
The vascular network is established and maintained through the processes of vasculogenesis and angiogenesis, which are tightly regulated during...
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Machine learning–based operation skills assessment with vascular difficulty index for vascular intervention surgery
An accurate assessment of surgical operation skills is essential for improving the vascular intervention surgical outcome and the performance of...
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Aortic Dissection is Determined by Specific Shape and Hemodynamic Interactions
The aim of this study was to determine whether specific three-dimensional aortic shape features, extracted via statistical shape analysis (SSA),...
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COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease...
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Loss with ageing but preservation of frontal cortical capillary pericytes in post-stroke dementia, vascular dementia and Alzheimer’s disease
Cerebral pericytes are an integral component of the neurovascular unit, which governs the blood–brain barrier. There is paucity of knowledge on...
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Multimodality imaging reveals angiogenic evolution in vivo during calvarial bone defect healing
The healing of calvarial bone defects is a pressing clinical problem that involves the dynamic interplay between angiogenesis and osteogenesis within...
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Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity
Transient receptor potential vanilloid 4 (TRPV4) is a ubiquitously expressed polymodally activated ion channel. TRPV4 has been implicated in tumor...
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Fractal-Based Analysis of Arteriovenous Malformations (AVMs)
Arteriovenous malformations (AVMs) are cerebrovascular lesions consisting of a pathologic tangle of the vessels characterized by a core termed the... -
The roles of collagen in chronic kidney disease and vascular calcification
The extracellular matrix component collagen is widely expressed in human tissues and participates in various cellular biological processes. The...
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Integrating oculomics with genomics reveals imaging biomarkers for preventive and personalized prediction of arterial aneurysms
ObjectiveArterial aneurysms are life-threatening but usually asymptomatic before requiring hospitalization. Oculomics of retinal vascular features...
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Retinal peri-arteriolar versus peri-venular amyloidosis, hippocampal atrophy, and cognitive impairment: exploratory trial
The relationship between amyloidosis and vasculature in cognitive impairment and Alzheimer’s disease (AD) pathogenesis is increasingly acknowledged....
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Three-Dimensional Imaging of Fibrinogen and Neurovascular Alterations in Alzheimer’s Disease
Cerebrovascular dysfunction is a hallmark of Alzheimer’s disease (AD) that is linked to cognitive decline. However, blood-brain barrier (BBB)... -
Customizable tubular model for n-furcating blood vessels and its application to 3D reconstruction of the cerebrovascular system
Understanding the 3D cerebral vascular network is one of the pressing issues impacting the diagnostics of various systemic disorders and is helpful...
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Endothelial cells require functional FLVCR1a during developmental and adult angiogenesis
The Feline Leukemia Virus Subgroup C Receptor 1a (FLVCR1a) is a transmembrane heme exporter essential for embryonic vascular development. However,...
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Modeling Gasotransmitter Availability to Brain Capillary Endothelial Cells with Ultrasound-sensitive Microbubbles
BackgroundVascular cognitive impairment and dementia results from blood components passing through disrupted blood brain barriers (BBBs). Current...
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Evaluation of the Morphological and Biological Functions of Vascularized Microphysiological Systems with Supervised Machine Learning
Vascularized microphysiological systems and organoids are contemporary preclinical experimental platforms representing human tissue or organ function...
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Localized conditional induction of brain arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia
BackgroundLongitudinal mouse models of brain arteriovenous malformations (AVMs) are crucial for develo** novel therapeutics and pathobiological...
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Loeys-Dietz Syndrome
Loeys-Dietz syndrome is an autosomal dominant aortic aneurysm syndrome characterized by multisystemic involvement. The most typical clinical triad... -
Neurovascular abnormalities in retinopathy of prematurity and emerging therapies
Blood vessels in the develo** retina are formed in concert with neural growth, resulting in functional neurovascular network. Disruption of the...
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Macular vessel density in the superficial plexus is not a proxy of cerebrovascular damage in non-demented individuals: data from the NORFACE cohort
IntroductionOptical coherence tomography angiography (OCT-A) is a novel tool that allows the detection of retinal vascular changes. We investigated...