Search
Search Results
-
Dual Role of TRPV1 Channels in Cerebral Stroke: An Exploration from a Mechanistic and Therapeutic Perspective
Transient receptor potential vanilloid subfamily member 1 (TRPV1) has been strongly implicated in the pathophysiology of cerebral stroke. However,...
-
Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine
BackgroundIngestion of alcoholic beverages is a known trigger of migraine attacks. However, whether and how ethanol exerts its pro-migraine action...
-
Transient Receptor Potential (TRP) Ion Channels in Orofacial Pain
Orofacial pain, including temporomandibular joint disorders pain, trigeminal neuralgia, dental pain, and debilitating headaches, affects millions of...
-
Discoidin Domain Receptor 1 as Modifier of Collagen in Tumor Extracellular Matrix: Recent Advances and Therapeutic Possibilities
Purpose of ReviewImmune exclusion and dormancy in cancer pose hurdles in successful cancer therapy. The review details the role played by discoidin...
-
Implications of Transient Receptor Potential Cation Channels in Migraine Pathophysiology
Migraine is a common and debilitating headache disorder. Although its pathogenesis remains elusive, abnormal trigeminal and central nervous system...
-
Resiniferatoxin Hampers the Nocifensive Response of Caenorhabditis elegans to Noxious Heat, and Pathway Analysis Revealed that the Wnt Signaling Pathway is Involved
Resiniferatoxin (RTX) is a metabolite extracted from Euphorbia resinifera . RTX is a potent capsaicin analog with specific biological activities...
-
Alterations in the microenvironment and the effects produced of TRPV5 in osteoporosis
The pathogenesis of osteoporosis involves multiple factors, among which alterations in the bone microenvironment play a crucial role in disrupting...
-
Activation of transient receptor potential vanilloid 4 channels dilates rat retinal arterioles through nitric oxide- and BKCa channel-dependent mechanisms in vivo
Transient receptor potential vanilloid 4 (TRPV4) channel, a cation channel expressed in nearly all cell types, plays an important role in the...
-
Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro
BackgroundPain relief remains a major subject of inadequately met need of patients. Therapeutic agents designed to treat pain and inflammation so far...
-
TRPC Channels in Cardiac Arrhythmia: Their Role during Purinergic Activation Induced by Ischemia
Cardiac electrical activity is mainly determined by a set of voltage-dependent channels that control depolarizing currents carried by Na+ and Ca2+...
-
Hypothermia Attenuates Neurotoxic Microglial Activation via TRPV4
Therapeutic hypothermia (TH) provides neuroprotection. However, the cellular mechanisms underlying the neuroprotective effects of TH are not fully...
-
Maresin 1 promotes nerve regeneration and alleviates neuropathic pain after nerve injury
BackgroundPeripheral nerve injury (PNI) is a public health concern that results in sensory and motor disorders as well as neuropathic pain and...
-
Desensitization of transient receptor potential vanilloid type-1 (TRPV1) channel as promising therapy of irritable bowel syndrome: characterization of the action of palvanil in the mouse gastrointestinal tract
TRPV1 are involved in the control of the gastrointestinal (GI) functions and pain sensation. Their activation induces pain but it is followed by...
-
Cannabidivarin and cannabigerol induce unfolded protein response and angiogenesis dysregulation in placental trophoblast HTR-8/SVneo cells
Cannabidivarin (CBDV) and cannabigerol (CBG) are minor phytocannabinoids from Cannabis sativa , whose health benefits have been reported. However,...
-
TRPV1 nociceptors are required to optimize antigen-specific primary antibody responses to novel antigens
BackgroundKey to the advancement of the field of bioelectronic medicine is the identification of novel pathways of neural regulation of immune...
-
Effects of Chaerophyllum macropodum Boiss. leaves essential oil in inflammatory and neuropathic pain: uncovering the possible mechanism of action
BackgroundChaerophyllum macropodum Boiss. (popularly known as “Jafari farangi kohestani”) is a predominant medicinal plant traditionally utilized in...
-
Lipopolysaccharide pretreatment increases the sensitivity of the TRPV1 channel and promotes an anti-inflammatory phenotype of capsaicin-activated macrophages
BackgroundThe transient receptor potential vanilloid 1 (TRPV1) is well-established in neuronal function, yet its role in immune reactions remains...
-
Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection
Although STAT3 has been reported as a negative regulator of type I interferon (IFN) signaling, the effects of pharmacologically inhibiting STAT3 on...
-
Glycerol 3-phosphate dehydrogenases (1 and 2) in cancer and other diseases
The glycerol 3-phosphate shuttle (GPS) is composed of two different enzymes: cytosolic NAD + -linked glycerol 3-phosphate dehydrogenase 1 (GPD1) and...
-
Exercise Improves Orofacial Pain and Modifies Neuropeptide Expression in a Rat Model of Parkinson’s Disease
Pain is a common non-motor symptom of Parkinson's disease (PD), which often occurs in the early disease stages. Despite the high prevalence, it...
