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Cationic liposomes as promising vehicles for timolol/brimonidine combination ocular delivery in glaucoma: formulation development and in vitro/in vivo evaluation
Glaucoma is a chronic eye disease in which the pressure inside the eye increases and leads to damage to the optic nerve, and eventually causes...
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Co-delivery of artemisinin and metformin via PEGylated niosomal nanoparticles: potential anti-cancer effect in treatment of lung cancer cells
PurposeDespite the advances in treatment, lung cancer is a global concern and necessitates the development of new treatments. Biguanides like...
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Design and Evaluation of Continentalic Acid Encapsulated Transfersomal Gel and Profiling of its Anti-arthritis Activity
Rheumatoid arthritis restricts the physical ability of patients and increases the disease burden; therefore, research has always been focused on...
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Effects of arginine on coenzyme-Q10 micelle uptake for mitochondria-targeted nanotherapy in phenylketonuria
Phenylketonuria (PKU) is a rare inherited metabolic disease characterized by phenylalanine hydroxylase enzyme deficiency. In PKU patients, coenzyme...
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Formulation of sustained-release orodispersible film containing drug–resin complexes of donepezil hydrochloride
PurposeThis study was aimed at develo** sustained-release orodispersible films (ODFs) based on drug–resin complexes (DRCs) to improve medication...
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Preparation and In Vitro and In Vivo Evaluation of a Testosterone Film Forming Gel for the Treatment of Hypoactive Sexual Desire Disorder in Women
Hypoactive sexual desire disorder (HSDD) is one of the most common sexual complaints in women. Currently, there is an unmet need for a drug treatment...
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RGD-decorated nanoliposomes for combined delivery of arsenic trioxide and curcumin to prostate cancer cells
Nanotechnology and drug co-delivery offer a novel avenue in drug delivery research liposome-based co-delivery of anticancer drugs targeting the...
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Exploring Liposomal Systems for Gallic Acid and Tannic Acid Delivery: Potential Strategies to Address Inflammation and Infections in Pediatric Ventricular Assist Device Recipients
IntroductionPediatric heart failure imposes a significant health burden, necessitating effective interventions. Left ventricular assist devices...
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Structural Changes in Liposomal Vesicles in Association with Sodium Taurodeoxycholate
Liposomes composed of soy lecithin (SL) have been studied widely for drug delivery applications. The stability and elasticity of liposomal vesicles...
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Antileishmanial Agents Co-loaded in Transfersomes with Enhanced Macrophage Uptake and Reduced Toxicity
The prime objective of this study was to develop amphotericin B (AMB) and rifampicin (RIF) co-loaded transfersomal gel (AMB-RIF co-loaded TFG) for...
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Nanospanlastics as a Novel Approach for Improving the Oral Delivery of Resveratrol in Lipopolysaccharide-Induced Endotoxicity in Mice
PurposeResveratrol (RSV) is a natural polyphenolic compound that has numerous biological effects. Owing to its poor bioavailability, only trace...
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Thymol-loaded liposomes effectively induced apoptosis and decreased EGFR expression in colorectal cancer cells
BackgroundColorectal cancer (CRC) is one of the most common and deadly cancers worldwide. Different factors, such as environmental and genetic...
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Assembly of In-Situ Gel Containing Nano-Spanlastics of an Angiotensin II Inhibitor as a Novel Epitome for Hypertension Management: Factorial Design Optimization, In-vitro Gauging, Pharmacokinetics, and Pharmacodynamics Appraisal
More than 1 billion people worldwide suffer from hypertension; therefore, hypertension management has been categorized as a global health priority....
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Inhaled Indomethacin-Loaded Liposomes as Potential Therapeutics against Non-Small Cell Lung Cancer (NSCLC)
Most lung cancer instances are non-small cell lung cancers (NSCLC). As stated by recent literature, cycloxygenase-2 (COX-2) is upregulated in lung...
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Formulation and characterization of liposomes containing drug absorption enhancers for optimized anti-HIV and antimalarial drug delivery
Most of the current clinically used anti-HIV and antimalarial drugs have low bioavailability, either due to poor solubility and permeability, rapid...
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Formulation of Metoclopramide Hydrochloride-Loaded Lipid Carriers by QbD Approach for Combating Nausea: Safety and Bioavailability Evaluation in New Zealand Rabbit
The focus of the research was to overcome the limitations of metoclopramide (MTC) when administered intranasally. The aim was to improve its...
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Formulation, Optimization, and Antioxidant Evaluation of Tetrahydrocurcumin-Loaded Ultradeformable Nanovesicular Cream
PurposeTetrahydrocurcumin (THC) has excellent anti-inflammatory and antioxidant properties, but its poor aqueous solubility limits its use in...
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Cancer cell membrane-decorated hybrid liposomes for treating metastatic breast cancer based on enhanced cancer immunotherapy
PurposeOur goal was to increase the targetability of our nanoparticles to specific targets to increase their penetration into the tumor and to...
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Bioavailability enhancement of vitamin E TPGS liposomes of nintedanib esylate: formulation optimization, cytotoxicity and pharmacokinetic studies
Nintedanib esylate is a kinase inhibitor designated for the cure of non-small cell lung cancer suffered from first-pass metabolism which resulted in...
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Co-delivery of Brinzolamide and Timolol from Micelles-laden Contact Lenses: In vitro and In Vivo Evaluation
PurposeTraditional eye drops exhibit a modest bioavailability ranging from 1 to 5%, necessitating recurrent application. Thus, a contact lens-based...
