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Sodium-glucose cotransporter-2 inhibitor in risk of sepsis/septic shock among patients with type 2 diabetes mellitus—a retrospective analysis of nationwide medical claims data
This research is an attempt to investigate the benefit of sodium-glucose cotransporter-2 inhibitor (SGLT2I) use in patients with diabetes mellitus...
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Sixty Years of Drug Discovery for Type 2 Diabetes: Where Are We Now?
Today, excluding insulin, there are eight classes of anti-diabetic medicines that have been added to the pharmacy since the introduction of metformin...
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The association between anti-diabetic agents and osteoporosis, sarcopenia, and osteosarcopenia among Iranian older adults; Bushehr Elderly Health (BEH) program
PurposeVarious risk factors are mentioned for osteoporosis, sarcopenia, and osteosarcopenia. Our aim is to assess the impacts of anti-diabetic drugs...
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Type 1 and Type 2 Diabetes Mellitus
Diabetes is now a rapidly growing global health problem. The number of people with diabetes has risen from 180 million in 1980 to 422 million in...
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Drug Repurposing in Gastric Cancer: Current Status and Future Perspectives
Gastric cancer remains an important contributor to the global cancer burden ranking the 5th most common and the 4th most deadly cancer, according to...
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Molecular docking of antidiabetic molecules of libas (Spondias pinnata) fruit and prediction of their pharmacokinetic properties
Diabetes mellitus is one of the chronic metabolic disorders that affects more than 16 million Filipinos. Proper education, medical intervention, and...
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Scientific and ethical issues in add-on designs for antidiabetic drugs
This editorial describes the clinical trials related to antidiabetic drugs, most of them following an “add-on” design of where the new drug is added...
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Resistin as a Biomarker and Applications to Prediabetes
Resistin is a cysteine-rich protein, secreted from mature human adipocytes. Resistin has 108 amino acids. The resistin coding gene area is located on...
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Current knowledge of bone-derived factor osteocalcin: its role in the management and treatment of diabetes mellitus, osteoporosis, osteopetrosis and inflammatory joint diseases
Osteocalcin (OC) is the most abundant non-collagenous and osteoblast-secreted protein in bone. It consists of two forms such as carboxylated OC (cOC)...
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Risk of New-onset Stroke in Patients with Type 2 Diabetes with Chronic Kidney Disease on Sodium-glucose Co-transporter-2 Inhibitor Users
Clinical studies have investigated the effects of using sodium-glucose co-transporter-2 (SGLT2) inhibitors on the development of new-onset stroke...
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Synergistic Herb Interactions with Antidiabetic Drugs
Diabetes is the most common endocrine and metabolic abnormality identified by hyperglycemia. The antidiabetic medicine available in the market is...
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Parkinson’s Disease and Type 2 Diabetes Mellitus: Interrelated Pathogenetic Mechanisms and Common Therapeutic Approaches
This review discusses the epidemiological, clinical, and pathophysiological aspects of the relationship between Parkinson’s disease (PD) and type 2...
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Precision Medicine in Diabetes
Tailoring treatment or management to groups of individuals based on specific clinical, molecular, and genomic features is the concept of precision...
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Probiotics in the Management of Diabetes
Probiotic is an expedient dietary supplement which is having a positive effect on the host in the intestinal tract. In recent years, there has been...
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Amorfrutin B Protects Mouse Brain Neurons from Hypoxia/Ischemia by Inhibiting Apoptosis and Autophagy Processes Through Gene Methylation- and miRNA-Dependent Regulation
Amorfrutin B is a selective modulator of the PPARγ receptor, which has recently been identified as an effective neuroprotective compound that...
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An insight into thymidylate synthase inhibitor as anticancer agents: an explicative review
Cancer, a widespread challenge to global health, remains a puzzle of intricate molecular dynamics. This review article delves into the mystery of...
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Mitochondrial metabolic dysfunction and non-alcoholic fatty liver disease: new insights from pathogenic mechanisms to clinically targeted therapy
Metabolic dysfunction-associated fatty liver disease (MAFLD) is among the most widespread metabolic disease globally, and its associated...
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α-Glucosidase Inhibitors for Diabetes/Blood Sugar Regulation
According to a recent analysis, nearly 450 million people get affected by type 2 diabetes, which corresponds to 6.28% of our population. Type 2...