Search
Search Results
-
Synthesis, spectroscopic characterization, and anticancer activity of new 10-substituted 1,6-diazaphenothiazines
New phenothiazine derivatives as 10-substituted dipyridothiazines of the 1,6-diazaphenothiazine structure were obtained in the cyclization reaction...
-
Antibiotics
In this chapter we discuss the drug class of antibiotics. There is a wide range of antibiotics available to treat a wide range of infections and...
-
A walk through tau therapeutic strategies
Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer’s disease and related human tauopathies. There is a growing body of...
-
AAV Gene Augmentation Therapy for CRB1-Associated Retinitis Pigmentosa
MutationsMutations in the CRB1 gene account for around 10,000 persons with Leber congenital amaurosis (LCA) and 70,000 persons with retinitis...
-
Antimalarial Drug Resistance: Clinical Perspectives
Despite efforts to discover new antiplasmodial drugs and to accomplish effective implementation of therapeutic combinations for malaria treatment by...
-
Synthesis of quinoline/naphthalene-containing azaphenothiazines and their potent in vitro antioxidant properties
New tetracyclic and pentacyclic azaphenothiazines containing one or two quinoline rings instead of benzene rings were obtained in the original...
-
NO Activity and Rho Kinase Activity
The endothelium releases a labile, diffusible, vasorelaxing substance that has been termed endothelium-derived relaxing factor (EDRF) (Furchgott and...
-
Anti-HIV activity of new pyrazolobenzothiazine 5,5-dioxide-based acetohydrazides
A series of fifteen new 2-[3-(3-chlorophenyl)-5,5-dioxidobenzo[e]pyrazolo[4,3-c][1,2]thiazin-4(2H)-yl]- N ′-arylmethyleneacetohydrazides ( 5a–o ) were...
-
Discovery and structure activity relationships of 2-pyrazolines derived from chalcones from a pest management perspective
Synthesis of chalcones and 2-pyrazoline derivatives has been an active field of research due to the established pharmacological effects of these...
-
Synthesis and selected immunological properties of 10-substituted 1,8-diazaphenothiazines
A new type of tricyclic azaphenothiazines—1,8-diazaphenothiazines—was obtained in the reaction of 2,3- and 3,4-disubstituted pyridines. The reaction...
-
NO Activity and Rho Kinase Activity
The endothelium releases a labile, diffusible, vasorelaxing substance that has been termed endothelium-derived relaxing factor (EDRF) (Furchgott and...
-
Synthesis, molecular docking and antiviral screening of novel N′-substitutedbenzylidene-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazides
N ′-Substitutedbenzylidene-2-(4-methyl-5,5-dioxido-3-phenylbenzo[ e ]pyrazolo[4,3- c ][1,2]thiazin-1(4 H )-yl)acetohydrazides ( 7a – u ) were synthesized...
-
Synthesis and in vitro antiproliferative activity of novel 12(H)-quino[3,4-b][1,4]benzothiazine derivatives
Novel method of N-dealkylating quinobenzothiazinium salts 2, promoted by reaction with benzimidazole, led to a series of new azaphenothiazine...
-
Synthesis of novel pyrazolobenzothiazine 5,5-dioxide derivatives as potent anti-HIV-1 agents
A new series of pyrazolobenzothiazine-based carbohydrazides was prepared in a facile way, starting with commercially available sodium saccharine. The...
-
Synthesis and antimicrobial activity of novel bis-azaphenothiazines
N -alkylation of azaphenothiazines using dibromoalkanes or dibromoalkenes did not result in the formation of bis-azaphenothiazines under known...
-
Synthesis of new series of pyrimido[4,5-b][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism
A series of 2-substituted 4- n -propyl pyrimido[4,5- b ][1,4]benzothiazines were synthesized, and evaluated as soybean 15-lipoxygenase (SLO) inhibitors....
-
Synthesis and antioxidant studies of novel N-substituted benzyl/phenyl-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-2(4H)-yl)acetamides
AbstractTwo new series of twenty-two N -substituted benzyl/phenyl-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3- c ][1,2]benzothiazin-2(4 H )-yl)acetamides...
-
Binding Interactions of Toluidine Blue O with Escherichia Coli DNA: Formation of Bridged Structure
The interaction(s) of Toluidine Blue O (TBO) with DNA was investigated using absorption and emission spectral methods. The binding of TBO with DNA...
-
Hydroxamic Acids as Matrix Metalloproteinase Inhibitors
Matrix metalloproteinases (MMPs), an increasing family of zinc- and calcium-dependent endopeptidases, are involved in both the tissue remodeling and...