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Research progress on non-protein-targeted drugs for cancer therapy
Non-protein target drugs, especially RNA-based gene therapies for treating hereditary diseases, have been recognized worldwide. As cancer is an...
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Tumor Microenvironment and Tumor-Targeted Therapy
Cancer tissue or cancer cells do not exist in isolation, but start life within the microenvironment called tumor microenvironment (TME). The...
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Trastuzumab-functionalized bionic pyrotinib liposomes for targeted therapy of HER2-positive breast cancer
In this study, we prepared a bionic nanosystem of trastuzumab-functionalized SK-BR-3 cell membrane hybrid liposome-coated pyrotinib (Ptb-M-Lip-Her)...
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Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy
Proteolysis targeting chimeras (PROTACs) have emerged as revolutionary anticancer therapeutics that degrade disease-causing proteins. However, the...
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Targeted therapy using nanocomposite delivery systems in cancer treatment: highlighting miR34a regulation for clinical applications
The clinical application of microRNAs in modern therapeutics holds great promise to uncover molecular limitations and conquer the unbeatable castle...
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Trastuzumab for Active Targeting in Cancer Therapy
With the advent of targeted therapies came a new paradigm for cancer treatment. The specific interaction between ligands and surface receptors has...
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Personalized Nanoparticles for Cancer Therapy
The fields of nanomedicine and personalized medicine have gained significant interest in advancing cancer treatment. The heterogeneous...
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Clinical application of targeted tumour sequencing tests for detecting ERBB2 amplification and optimizing anti-HER2 therapy in gastric cancer
BackgroundEvaluation of human epidermal growth factor receptor 2 (HER2) overexpression caused by erb-b2 receptor tyrosine kinase 2 ( ERBB2 )...
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Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer
Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset of tumor cells characterized by surface markers such...
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Is metabolism the magic bullet for targeted cancer therapy?
Altered cellular metabolism has long been recognized as a hallmark of cancer. Oncogenic signaling cascades induce metabolic rewiring that further...
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Impact of body mass index in therapeutic response for HER2 positive breast cancer treated with neoadjuvant targeted therapy: a multi-center study and meta-analysis
While overweight/obesity has become a major public health issue worldwide, any association between body mass index (BMI) and therapeutic response in...
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An Insight into Targeted Therapy for Ovarian Cancer
Ovarian cancer (OC) is one of the most fatal gynecological malignancies in the world. Poor diagnosis and a lack of prognostic biomarkers have...
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An Insight into Targeted Therapy for Ovarian Cancer
Ovarian cancer (OC) is one of the most fatal gynecological malignancies in the world. Poor diagnosis and a lack of prognostic biomarkers have...
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Investigating druggable kinases for targeted therapy in retinoblastoma
Retinoblastoma (RB) is a childhood retinal neoplasm and commonly treated with cytotoxic chemotherapeutic agents. However, these therapeutic...
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Transcription factor BACH1 in cancer: roles, mechanisms, and prospects for targeted therapy
Transcription factor BTB domain and CNC homology 1 (BACH1) belongs to the Cap ‘n’ Collar and basic region Leucine Zipper (CNC-bZIP) family. BACH1 is...
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CRISPR-Cas and CRISPR-based screening system for precise gene editing and targeted cancer therapy
Target cancer therapy has been developed for clinical cancer treatment based on the discovery of CRISPR (clustered regularly interspaced short...
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Nanoparticle delivery of TFOs is a novel targeted therapy for HER2 amplified breast cancer
PurposeThe human EGFR2 ( HER2 ) signaling pathway is one of the most actively studied targets in cancer transformation research. Ttriplex-forming...
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Molecular targeted therapy for anticancer treatment
Since the initial clinical approval in the late 1990s and remarkable anticancer effects for certain types of cancer, molecular targeted therapy...
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Personalized targeted therapy prescription in colorectal cancer using algorithmic analysis of RNA sequencing data
Background:Overall survival of advanced colorectal cancer (CRC) patients remains poor, and gene expression analysis could potentially complement...
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Heterogeneity and molecular landscape of melanoma: implications for targeted therapy
Uveal cancer (UM) offers a complex molecular landscape characterized by substantial heterogeneity, both on the genetic and epigenetic levels. This...
