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The impact of CD4+CD28null T lymphocytes on atrial fibrillation: a potential pathophysiological pathway
IntroductionAtrial fibrillation (AF) represents the most common cardiac arrhythmia in daily clinical practice and substantially impacts affected...
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Viral Cytotoxic T Lymphocytes (CTLs): From Bench to Bedside
It was first demonstrated almost three decades ago that adoptive transfer of viral-specific T cells could prevent or eradicate viral disease in...
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Exercise 20: Mitogen Induced Response of Lymphocytes. Detection of B and T Lymphocytes Using Immunofluorescence
Mitogens are substances, which are capable of inducing mitosis in cells of the immune system. B and T lymphocytes are induced to proliferate when...
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Pan-cancer analysis reveals RIPK2 predicts prognosis and promotes immune therapy resistance via triggering cytotoxic T lymphocytes dysfunction
BackgroundReceptor-interacting protein kinase 2 (RIPK2, also known as RIP2) was reported to be associated with bacterial infections as well as...
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Beneficial Effect of Fingolimod in a Lafora Disease Mouse Model by Preventing Reactive Astrogliosis-Derived Neuroinflammation and Brain Infiltration of T-lymphocytes
Lafora disease (LD; OMIM#254780) is a rare, devastating, and fatal form of progressive myoclonus epilepsy that affects young adolescents and has no...
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γδ T Lymphocytes in Asthma: a Complicated Picture
A minor subset (approximately 5%) of peripheral T cells has their TCR build up from γ and δ chains instead of α and β—those are the γδ T lymphocytes....
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Cycling and activated CD8+ T lymphocytes and their association with disease severity in influenza patients
BackgroundT cell lymphopenia was a significant characteristic of severe influenza infection and it was associated with the functional changes of T...
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Programmed death ligand 1 and tumor-infiltrating CD8+ T lymphocytes are associated with the clinical features in meningioma
ObjectiveTo investigate the expression of programmed death ligand-1 (PD-L1) and the levels of CD8 + tumor-infiltrating lymphocytes (TILs) in...
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Patients with Chromosome 11q Deletions Are Characterized by Inborn Errors of Immunity Involving both B and T Lymphocytes
Disorders of the long arm of chromosome 11 (11q) are rare and involve various chromosomal regions. Patients with 11q disorders, including Jacobsen...
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Characterization of Cytotoxic T Lymphocytes (CTL) by Tissue Microarray
Tissue microarray (TMA) is a smart technical innovation recently imposed in pathology research. This technology provides a high-throughput analysis...
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Exercise 22: Adoptive Transfer of Lymphocytes: B and T Lymphocyte Cooperation for Antibody Production
In this exercise, we will demonstrate that combinations of B and T lymphocytes are required to efficiently produce antibodies against antigen. We...
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Differences in pyroptosis of recent thymic emigrants CD4+ T Lymphocytes in ART-treated HIV-positive patients are influenced by sex
Pyroptosis cell death in recent thymus emigrants (RTE) CD4+ T lymphocytes plays an important role on HIV-1 infection as a cause of CD4+ T cell...
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Recent advances on the role of cytotoxic T lymphocytes in the pathogenesis of spondyloarthritis
Spondyloarthritis (SpA) is a chronic inflammatory disorder with complex etiology and pathogenesis. Its pathogenesis likely involves a combination of...
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WNT7A Expression is Downregulated in T Lymphocytes after T-Cell Receptor Activation Due to Histone Modifications and in T-ALL by DNA Methylation
WNT signaling pathway regulates several processes involved in the homeostasis of normal cells. Its dysregulation is associated with pathological...
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Molecular and cellular characterization of European sea bass CD3ε+ T lymphocytes and their modulation by microalgal feed supplementation
The CD3 coreceptor is a master T cell surface marker, and genes encoding CD3 ζ , γδ, and ε chains have been reported in several teleost fish. Here, a...
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mRNA Transfection of T-Lymphocytes by Electroporation
Electroporation enables the transfection of different cell types including microbial, plant, and animal cells with charged molecules, such as nuclear...
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Progressive Depletion of B and T Lymphocytes in Patients with Ataxia Telangiectasia: Results of the Italian Primary Immunodeficiency Network
Ataxia telangiectasia (AT) is a rare neurodegenerative genetic disorder due to bi-allelic mutations in the Ataxia Telangiectasia Mutated ( ATM ) gene....
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The role of CD8 + T lymphocytes in chronic obstructive pulmonary disease: a systematic review
Objective and designThis systematic review aims to establish the role of CD8 + T lymphocytes in COPD.
MethodsForty-eight papers published in the...
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Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer
BackgroundAlthough high T cell density is a strong favourable prognostic factor in colorectal cancer, the significance of the spatial distribution of...
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The mutational load and a T-cell inflamed tumour phenotype identify ovarian cancer patients rendering tumour-reactive T cells from PD-1+ tumour-infiltrating lymphocytes
BackgroundAdoptive immunotherapy with tumour-infiltrating lymphocytes (TIL) may benefit from the use of selective markers, such as PD-1, for...
