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Celastrol ameliorates energy metabolism dysfunction of hypertensive rats by dilating vessels to improve hemodynamics
AbstractThe impact of hypertension on tissue and organ damage is mediated through its influence on the structure and function of blood vessels. This...
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Activation of NLRP3 inflammasome in a rat model of cerebral small vessel disease
Cerebral small vessel disease (CSVD) is increasingly being recognized as a leading contributor to cognitive impairment in the elderly. However, there...
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Upregulation of Glutamatergic Receptors in Hippocampus and Locomotor Hyperactivity in Aged Spontaneous Hypertensive Rat
Epidemiologic studies have indicated that chronic hypertension may facilitate the progression of abnormal behavior, such as emotional irritability,...
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Natural genetic variation in Stim1 creates stroke in the spontaneously hypertensive rat
Similar to humans, the risk of cerebrovascular disease in stroke-prone spontaneously hypertensive rats (SHR-A3/SHRSP) arises from naturally occurring...
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Impaired thermoregulation in spontaneously hypertensive rats during physical exercise is related to reduced hypothalamic neuronal activation
This study aimed to evaluate the physical exercise-induced neuronal activation in brain nuclei controlling thermoregulatory responses in hypertensive...
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Impaired UTP-induced relaxation in the carotid arteries of spontaneously hypertensive rats
Uridine 5′-triphosphate (UTP) has an important role as an extracellular signaling molecule that regulates inflammation, angiogenesis, and vascular...
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Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in spontaneously hypertensive rats: effect of renal denervation
Primary acute sympathetic activation (PASA) causes a subsequent arterial pressure (AP) elevation. In this case, an antidiuretic effect via the renal...
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Defective Function of the Blood–Brain Barrier in a Stroke-Prone Spontaneously Hypertensive Rat: Evaluation in an In Vitro Cell Culture Model
The blood–brain barrier (BBB) comprises three cell types: brain capillary endothelial cells (BECs), astrocytes, and pericytes. Abnormal interaction...
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Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats
BackgroundEpidemiological evidence has linked fine particulate matter (PM 2.5 ) to neurodegenerative diseases; however, the toxicological evidence...
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Quercetin decreases cardiac hypertrophic mediators and maladaptive coronary arterial remodeling in renovascular hypertensive rats without improving cardiac function
Oxidative stress and MMP activity are found in the hearts and arteries in hypertension and contribute to the resulting hypertrophy and dysfunction....
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Phenotype Shifting in Astrocytes Account for Benefits of Intra-Arterial Selective Cooling Infusion in Hypertensive Rats of Ischemic Stroke
The translational failure of neuroprotective therapies in stroke may be influenced by the mismatch of existing comorbidities between animal models...
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Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans
The mechanisms by which physical exercise benefits brain functions are not fully understood. Here, we show that vertically oscillating head motions...
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Nebivolol combined with tetrahydrobiopterin affects diastolic function in spontaneously hypertensive rats via the nitric oxide/cyclic guanosine monophosphate signalling pathway
BackgroundHypertension is the the primary cause of diastolic heart failure. Oxidative stress plays an important role in cardiac diastolic dysfunction...
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Cerebral Perfusion Characteristics and Dynamic Brain Structural Changes in Stroke-Prone Renovascular Hypertensive Rats: A Preclinical Model for Cerebral Small Vessel Disease
Hypertension is a leading cause of cerebral small vessel disease (CSVD) and vascular dementia in elderly individuals. We aimed to assess cerebral...
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Motor Activity and Levels of Expression of mRNA for the Proteins NAP-22 and GAP-43 in Spontaneously Hypertensive Rats
The aim of the present work was to identify differences in movement activity in SHR and WKY rats and to assess the levels of expression of mRNA for...
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Central Blockade of E-Prostanoid 3 Receptor Ameliorated Hypertension Partially by Attenuating Oxidative Stress and Inflammation in the Hypothalamic Paraventricular Nucleus of Spontaneously Hypertensive Rats
Hypertension, as one of the major risk factors for cardiovascular disease, significantly affects human health. Prostaglandin E 2 (PGE 2 ) and the...
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α2C-Adrenergic Receptor Blockade Inhibits Langendorff-Isolated Rat Heart Work
We studied the effect of selective α 2C -adrenergic receptor antagonist JP-1302 in concentrations of 10 —9 -10 —6 M on inotropy, chronotropy, and coronary...
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Systemic Administrations of Water-Dispersible Single-Walled Carbon Nanotubes: Activation of NOS in Spontaneously Hypertensive Rats
Priority data have been obtained on the effects of repeated systemic administrations of water-dispersible single-walled carbon nanotubes (SWCNTs) to...
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Genetic effects in a progressive model of parkinsonism induced by reserpine
Objective and methodsWe investigated the locomotor, emotional, physiological, and neurobiological effects induced by low-dose reserpine repeated...
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Caffeine Consumption plus Physical Exercise Improves Behavioral Impairments and Stimulates Neuroplasticity in Spontaneously Hypertensive Rats (SHR): an Animal Model of Attention Deficit Hyperactivity Disorder
Attention deficit hyperactivity disorder (ADHD) is a prevalent and disabling disorder, mainly characterized by hyperactivity, inattention, and...
