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Alternative splicing in multiple myeloma is associated with the non-homologous end joining pathway
Alternative splicing plays a pivotal role in tumorigenesis and proliferation. However, its pattern and pathogenic role has not been systematically...
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Insulin receptor alternative splicing in breast and prostate cancer
Cancer etiology represents an intricate, multifactorial orchestration where metabolically associated insulin-like growth factors (IGFs) and insulin...
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Splicing alterations in pancreatic ductal adenocarcinoma: a new molecular landscape with translational potential
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers worldwide, mainly due to its late diagnosis and lack of effective...
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Surface PD-1 expression in T cells is suppressed by HNRNPK through an exonic splicing silencer on exon 3
ObjectiveImmunotherapy targeting programmed cell death 1 (PDCD1 or PD-1) and its ligands has shown remarkable promise and the regulation mechanism of...
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Splicing targeting drugs highlight intron retention as an actionable vulnerability in advanced prostate cancer
BackgroundAdvanced prostate cancer (PC) is characterized by insensitivity to androgen deprivation therapy and chemotherapy, resulting in poor outcome...
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CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity
Metabolic flexibility has emerged as a critical determinant of CD8+ T-cell antitumor activity, yet the mechanisms driving the metabolic flexibility...
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Formation of an invasion-permissive matrix requires TGFβ/SNAIL1-regulated alternative splicing of fibronectin
BackgroundAs in most solid cancers, the emergence of cells with oncogenic mutations in the mammary epithelium alters the tissue homeostasis. Some...
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Roles and mechanisms of aberrant alternative splicing in melanoma — implications for targeted therapy and immunotherapy resistance
BackgroundDespite advances in therapeutic strategies, resistance to immunotherapy and the off-target effects of targeted therapy have significantly...
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A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS–FTD
Although loss of TAR DNA-binding protein 43 kDa (TDP-43) splicing repression is well documented in postmortem tissues of amyotrophic lateral...
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Unraveling the Impact of Aberrant Splicing Machinery on Drug Resistance in Breast Cancer: Identifying Targets for Innovative Counteractive Strategies
The alternative splicing of pre-mRNA is an important process that increases the number of proteins a genome can code for and is important for nearly...
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Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop
BackgroundCircular RNAs play an important role in tumor genesis and progression, but they have not been sufficiently studied in patients with...
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Regulation of Alternative Splicing of Lipid Metabolism Genes in Sepsis-Induced Liver Damage by RNA-Binding Proteins
RNA binding proteins (RBPs) have the potential for transcriptional regulation in sepsis-induced liver injury, but precise functions remain unclear....
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Long-read sequencing reveals the landscape of aberrant alternative splicing and novel therapeutic target in colorectal cancer
BackgroundAlternative splicing complexity plays a vital role in carcinogenesis and cancer progression. Improved understanding of novel splicing...
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Alternative splicing as a source of phenotypic diversity
A major goal of evolutionary genetics is to understand the genetic processes that give rise to phenotypic diversity in multicellular organisms....
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Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects
The removal of introns from mRNA precursors and its regulation by alternative splicing are key for eukaryotic gene expression and cellular function,...
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PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing
Hepatocellular carcinoma (HCC) pathogenesis is associated with alterations in splicing machinery components (spliceosome and splicing factors) and...
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Novel compound heterozygous MYO15A splicing variants in autosomal recessive non-syndromic hearing loss
BackgroundHereditary hearing loss is a highly heterogeneous disorder. This study aimed to identify the genetic cause of a Chinese family with...
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Identification of Bone Metastatic and Prognostic Alternative Splicing Signatures in Prostate Adenocarcinoma
As the most common nonepithelial malignancy, prostate adenocarcinoma (PRAD) is the fifth chief cause of cancer mortality in men. Distant metastasis...
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Repression of the expression of proinflammatory genes by mitochondrial transcription factor A is linked to its alternative splicing regulation in human lung epithelial cells
BackgroundMitochondrial transcription factor A (TFAM) is associated with a number of neurodegenerative diseases and also with asthma. TFAM...
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IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis
Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that seriously affects the quality of life of patients due...
