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The difference between dacomitinib and afatinib in effectiveness and safety in first-line treatment of patients with advanced EGFR-mutant non-small cell lung cancer: a real-world observational study
ObjectivesThe irreversible epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) afatinib and dacomitinib are approved for...
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When to add anti-angiogenesis drugs to EGFR-mutated metastatic non–small cell lung cancer patients: a real-world study from Taiwan
BackgroundThe addition of anti-angiogenesis drugs to epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor (TKI) or chemotherapy in...
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Modulation of chemoimmunotherapy efficacy in non-small cell lung cancer by sex and histology: a real-world, patient-level analysis
BackgroundIt has been postulated that patient’s sex impacts response to immunotherapy. Sex modulation of immunotherapy benefit, however, has not yet...
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A text-mining approach to study the real-world effectiveness and potentially fatal immune-related adverse events of PD-1 and PD-L1 inhibitors in older patients with stage III/IV non-small cell lung cancer
BackgroundThis study was designed to investigate the impact of age on the effectiveness and immune-related adverse events (irAEs) of programmed...
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Factors associated with overall survival, progression-free survival and toxicity in patients with small cell lung cancer and thoracic irradiation in a clinical real-world setting
BackgroundSmall-cell lung cancer (SCLC) is a malignant tumor known for its poor prognosis. In addition to chemotherapy and immunotherapy irradiation...
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Retrospective analysis of real-world treatment patterns and clinical outcomes in patients with advanced non-small cell lung cancer starting first-line systemic therapy in the United Kingdom
BackgroundThe treatment landscape for advanced non-small cell lung cancer (aNSCLC) has evolved rapidly since immuno-oncology (IO) therapies were...
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Real world practice of postoperative radiotherapy for patients with completely resected pIIIA-N2 non-small cell lung cancer: a national survey of radiation oncologists in China
BackgroundResults from Lung ART and PORT-C trials suggest that postoperative radiotherapy (PORT) cannot routinely be recommended as standard...
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Real world duration of curative intent breast, colorectal, non-small cell lung, and prostate cancer treatment
BackgroundAdvances in curative treatment for breast, colorectal, NSCLC and prostate cancer have led to improvements in cancer survival. Cancer...
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Efficacy and acquired resistance of EGFR-TKI combined with chemotherapy as first-line treatment for Chinese patients with advanced non-small cell lung cancer in a real-world setting
BackgroundTo compare the benefits and explore the cause of acquired resistance of epidermal growth factor receptor tyrosine kinase inhibitor...
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Real-world treatment and survival of patients with advanced non-small cell lung Cancer: a German retrospective data analysis
BackgroundThe objective of this study was to describe the real-world treatment and overall survival (OS) of German patients with a diagnosis of...
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Characteristics and outcomes of patients with RET-fusion positive non-small lung cancer in real-world practice in the United States
BackgroundContradictory and limited data are available about the presentation and outcomes of patients with RET -fusion positive metastatic NSCLC as...
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Correction to: graph analysis of structural brain networks in Alzheimer’s disease: beyond small world properties
The original version of the article contained an error in the electronic supplementary material. The caption of the figure in the electronic...
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Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species
The major histocompatibility complex (MHC) is central to the innate and adaptive immune responses of jawed vertebrates. Characteristic of the MHC are...
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Altered functional brain networks in coronary heart disease: independent component analysis and graph theoretical analysis
Coronary heart disease (CHD) confers a high risk of cognitive and mental impairments in patients. This study aimed to explore the association of CHD...
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Synchronization and oscillation behaviors of excitatory and inhibitory populations with spike-timing-dependent plasticity
The effect of synaptic plasticity on the synchronization mechanism of the cerebral cortex has been a hot research topic over the past two decades....
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Disrupted topological organization of functional brain networks in traumatic axonal injury
Traumatic axonal injury (TAI) may result in the disruption of brain functional networks and is strongly associated with cognitive impairment....
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Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme
The Cancer Programme of the 100,000 Genomes Project was an initiative to provide whole-genome sequencing (WGS) for patients with cancer, evaluating...
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Identification of a novel monopartite begomovirus associated with leaf curl disease of Citharexylum spinosum in India
The present study reports the complete genome of a novel monopartite begomovirus, named tentatively as “Citharexylum leaf curl virus” (CitLCuV),...
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Electroencephalography-Derived Functional Connectivity in Sensorimotor Networks in Post Stroke Fatigue
BackgroundPoor suppression of anticipated sensory information from muscle contractions is thought to underlie high fatigue. Such diminished...
