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Transcriptomics of Human Brain Tissue in Parkinson’s Disease: a Comparison of Bulk and Single-cell RNA Sequencing
Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disease leading to motor dysfunction and, in some cases, dementia....
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Cell type-specific changes identified by single-cell transcriptomics in Alzheimer’s disease
The rapid advancement of single-cell transcriptomics in neurology has allowed for profiling of post-mortem human brain tissue across multiple...
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Fluorescence imaging deformability cytometry: integrating nuclear structure with mechanical phenoty**
Mechanical measurements of cells can provide unique insights into cell state and disease processes. The overall mechanical properties of cells can be...
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Integrating spatial and single-nucleus transcriptomic data elucidates microglial-specific responses in female cynomolgus macaques with depressive-like behaviors
Major depressive disorder represents a serious public health challenge worldwide; however, the underlying cellular and molecular mechanisms are...
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Dynamic chromosome association with nuclear organelles in living cells
The development of progressively sophisticated tools complemented by the integration of live cell imaging enhances our understanding of the...
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Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution
Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. The pathological hallmark of PD is loss of dopaminergic neurons and...
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Real-time single-molecule imaging of transcriptional regulatory networks in living cells
Gene regulatory networks drive the specific transcriptional programmes responsible for the diversification of cell types during the development of...
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Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk
Coronary artery disease (CAD) is a complex inflammatory disease involving genetic influences across cell types. Genome-wide association studies have...
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Multicellular communities are perturbed in the aging human brain and Alzheimer’s disease
The role of different cell types and their interactions in Alzheimer’s disease (AD) is a complex and open question. Here, we pursued this question by...
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NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve
Glaucoma is the leading cause of irreversible blindness and is a major health and economic burden. Current treatments do not address the...
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Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition
The amygdala processes positive and negative valence and contributes to addiction, but the cell-type-specific gene regulatory programs involved are...
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Preparation of Human and Rodent Spinal Cord Nuclei for Single-Nucleus Transcriptomic Analysis
The spinal cord is a complex and heterogeneous tissue that is composed of numerous neuronal and non-neuronal cell types. Single-cell RNA-seq has...
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Nucleus and cytoplasm–based segmentation and actor-critic neural network for acute lymphocytic leukaemia detection in single cell blood smear images
Acute lymphoblastic leukaemia (ALL), which is due to the malfunctioning in the bone marrow, is common among people all over the world. The...
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Characterizing dysregulations via cell-cell communications in Alzheimer’s brains using single-cell transcriptomes
BackgroundAlzheimer’s disease (AD) is a devastating neurodegenerative disorder affecting 44 million people worldwide, leading to cognitive decline,...
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Brain single cell transcriptomic profiles in episodic memory phenotypes associated with temporal lobe epilepsy
Memory dysfunction is prevalent in temporal lobe epilepsy (TLE), but little is known about the underlying molecular etiologies. Single-nucleus RNA...
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Tissue-specific enhancer–gene maps from multimodal single-cell data identify causal disease alleles
Translating genome-wide association study (GWAS) loci into causal variants and genes requires accurate cell-type-specific enhancer–gene maps from...
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Single-nucleus multi-omics of Parkinson’s disease reveals a glutamatergic neuronal subtype susceptible to gene dysregulation via alteration of transcriptional networks
The genetic architecture of Parkinson’s disease (PD) is complex and multiple brain cell subtypes are involved in the neuropathological progression of...
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IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice
Interleukin-12 (IL-12) is a potent driver of type 1 immunity. Paradoxically, in autoimmune conditions, including of the CNS, IL-12 reduces...
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Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development
Malformations of cortical development (MCD) are neurological conditions involving focal disruptions of cortical architecture and cellular...
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Generalized nuclear localization of retroelement transcripts
BackgroundLINE-1s, Alus and SVAs are the only retrotransposition competent elements in humans. Their mobilization followed by insertional mutagenesis...
