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Determination of trace elements and electrolyte levels in kidney tissue of simvastatin-treated septic rats
Trace elements are cofactors in various enzymes in the antioxidant defense and cell homeostasis required in the tissue during inflammation. In acute...
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Identifying hub genes of sepsis-associated and hepatic encephalopathies based on bioinformatic analysis—focus on the two common encephalopathies of septic cirrhotic patients in ICU
BackgroundIn the ICU ward, septic cirrhotic patients are susceptible to suffering from sepsis-associated encephalopathy and/or hepatic...
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Left knee septic monoarthritis in a pediatric patient due to shewanella putrefaciens: case report and literature review
BackgroundShewanella putrefaciens is a gram-negative, nonfermenting, oxidase-positive, hydrogen sulfide-producing bacillus and a halophilic...
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Inhibitory functions of cornuside on TGFBIp-mediated septic responses
Transforming growth factor β-induced protein (TGFBIp), as an extracellular matrix protein, is expressed TGF-β in some types of cells. Experimental...
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Involvement of CD44 and MAPK14-mediated ferroptosis in hemorrhagic shock
To elucidate the induction of ferroptotic pathways and the transcriptional modulation of pivotal genes in the context of hemorrhagic shock. The R...
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mTOR pathway mediates endoplasmic reticulum stress-induced CD4+ T cell apoptosis in septic mice
Endoplasmic reticulum stress (ERS) has been well documented to participate in the pathophysiological processes of apoptosis in many diseases....
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Septic shock caused by Capnocytophaga canis after a cat scratch
Capnocytophaga canis is an uncommon cause of septic shock. Only three cases have been previously reported in the literature. In this article, we...
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P2X7 receptor antagonist A-438079 alleviates oxidative stress of lung in LPS-induced septic rats
Sepsis is a deadly systemic inflammatory response of the body against infection resulting in immune response, cell differentiation and organ damage....
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The Role of Angiotensin II in Poisoning-Induced Shock—a Review
BackgroundShock in drug poisoning is a life-threatening condition and current management involves fluid resuscitation and vasopressor therapy....
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RBM3 is associated with acute lung injury in septic mice and patients via the NF-κB/NLRP3 pathway
Sepsis refers to host response disorders caused by infection, leading to life-threatening organ dysfunction. RNA-binding motif protein 3 (RBM3) is an...
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Urinary neutrophil gelatinase-associated lipocalin values alone and combined with Prognostic Index predict septic AKI, DIC, and shock: a pilot study
ObjectiveSepsis is a syndrome involving life-threatening organ dysfunction. The present study aimed to determine whether septic AKI, ARDS, DIC, and...
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Pyruvate Dehydrogenase Kinase 2 Accelerates Endotoxin Shock by Promoting Mitogen-Activated Protein Kinase Activation
Endotoxin shock remains one of the major causes of mortality worldwide. Pyruvate dehydrogenase kinase (PDK) 2 is an important regulatory enzyme...
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The Protective Effects of Perindopril Against Acute Kidney Damage Caused by Septic Shock
Acute kidney injury (AKI) resulting from septic shock caused by sepsis is an important health problem encountered at rates of 55–73%. Increasing...
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PD-L1 Blockade Improves Survival in Sepsis by Reversing Monocyte Dysfunction and Immune Disorder
Monocyte dysfunction is critical to sepsis-induced immunosuppression. Programmed death ligand-1 (PD-L1) has shown a close relationship with...
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Theaflavin mitigates acute gouty peritonitis and septic organ injury in mice by suppressing NLRP3 inflammasome assembly
Activation of NLR family pyrin domain-containing 3 (NLRP3) inflammasome plays important role in defending against infections, but its aberrant...
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Heat shock protein 27 in the pathogenesis of COVID-19 and non-COVID acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) is a common cause of hypoxemic respiratory failure in intensive care units that has increased dramatically...
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Clinical characteristics and prognostic risk factors of candidemia in non-neutropenic patients: a retrospective cohort study
This study aimed to determine the clinical characteristics and the prognostic risk factors in non-neutropenic patients with candidemia. Data were...
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The clinical trajectory of peripheral blood immune cell subsets, T-cell activation, and cytokines in septic patients
Objective and designChanges in the immune status of patients with sepsis may have a major impact on their prognosis. Our research focused on changes...
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Blood Cortisol as a Biomarker in Intensive Care Unit
Despite some issues are limiting the use of blood cortisol as an excellent biomarker in intensive care units, it is seen in literature that blood...
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The Therapeutic Effect of an Anti-TNF-α/HSA/IL-6R Triple-Specific Fusion Protein Under Experimental Septic Conditions
Sepsis caused by a dysregulated host response to infection is a life-threatening disease that can lead to organ dysfunction. Due to its unclear and...
