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Maternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord blood
BackgroundAdverse childhood experiences (ACEs) increase the risk of poor health outcomes later in life. Psychosocial stressors may also have...
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Prenatal metal exposure, cord blood DNA methylation and persistence in childhood: an epigenome-wide association study of 12 metals
BackgroundPrenatal exposure to essential and non-essential metals impacts birth and child health, including fetal growth and neurodevelopment. DNA...
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P
See Perception and Attention Deficit Model.
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Regulation of aberrantly expressed SERPINH1 by antitumor miR-148a-5p inhibits cancer cell aggressiveness in gastric cancer
RNA-sequencing-based microRNA (miRNA) expression signatures have revealed that miR-148a-5p (the passenger strand of the miR-148a -duplex) is...
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Implication of Neuronal Versus Microglial P2X4 Receptors in Central Nervous System Disorders
The P2X4 receptor (P2X4) is an ATP-gated cation channel that is highly permeable to Ca 2+ and widely expressed in neuronal and glial cell types...
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Membrane Transporters and Channels in Melanoma
Recent research has revealed that ion channels and transporters can be important players in tumor development, progression, and therapy resistance in...
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Vesicular nucleotide transporter (VNUT): appearance of an actress on the stage of purinergic signaling
Vesicular storage of ATP is one of the processes initiating purinergic chemical transmission. Although an active transport mechanism was postulated...
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Relative and Absolute Expression Analysis of MicroRNAs Associated with Luminal A Breast Cancer– A Comparison
MicroRNAs, as small non-coding regulatory RNAs, play crucial roles in various aspects of breast cancer biology. They have prognostic and diagnostic...
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The regulatory effect of microRNA-21a-3p on the promotion of telocyte angiogenesis mediated by PI3K (p110α)/AKT/mTOR in LPS induced mice ARDS
BackgroundTelocytes (TCs) are newly identified interstitial cells that participate in tissue protection and repair. The present study investigated...
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Clinical diagnosis of genetic disorders at both single-nucleotide and chromosomal levels based on BGISEQ-500 platform
Most variations in the human genome refer to single-nucleotide variation (SNV), small fragment insertions and deletions, and genomic copy number...
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Microglia in the CNS and Neuropathic Pain
Neuropathic pain occurring after peripheral nerve injury is not simply a consequence of temporal continuity of acute nociceptive signals, but rather...
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Transcriptome profile analysis reveals cardiotoxicity of maduramicin in primary chicken myocardial cells
Maduramicin, an excellent ionophore antibiotic, is extensively used to control coccidiosis in poultry. Numerous maduramicin intoxications have been...
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How intravesicular composition affects exocytosis
Large dense core vesicles and chromaffin granules accumulate solutes at large concentrations (for instance, catecholamines, 0.5–1 M; ATP, 120–300 mM;...
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Extracellular ATP and P2 purinergic signalling in the tumour microenvironment
Modulation of the biochemical composition of the tumour microenvironment is a new frontier of cancer therapy. Several immunosuppressive mechanisms...
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Gene expression profiling of idiopathic interstitial pneumonias (IIPs): identification of potential diagnostic markers and therapeutic targets
BackgroundChronic fibrosing idiopathic interstitial pneumonia (IIP) is characterized by alveolar epithelial damage, activation of fibroblast...
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Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential
Acute nociceptive pain is a key defence system that enables the detection of danger signals that threaten homeostasis and survival. However, chronic...
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Modulation of Pain and Itch by Spinal Glia
Chronic pain and itch are a pathological operation of the somatosensory system at the levels of primary sensory neurons, spinal cord and brain. Pain...
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Hyperosmotic stress induces ATP release and changes in P2X7 receptor levels in human corneal and conjunctival epithelial cells
Tear hyperosmolarity is a key event in dry eye. In this work, we analyzed whether hyperosmolar challenge induces ATP release on the ocular surface....
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Discovery and replication of a peripheral tissue DNA methylation biosignature to augment a suicide prediction model
BackgroundSuicide is the second leading cause of death among adolescents in the USA, and rates are rising. Methods to identify individuals at risk...
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Role of vesicular nucleotide transporter VNUT (SLC17A9) in release of ATP from AR42J cells and mouse pancreatic acinar cells
ATP is released from cells in response to various stimuli. Our previous studies on pancreas indicated that pancreatic acini could be major stores of...
