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Uncertainty Computation at Finite Distance in Nonlinear Mixed Effects Models—a New Method Based on Metropolis-Hastings Algorithm
AbstractThe standard errors (SE) of the maximum likelihood estimates (MLE) of the population parameter vector in nonlinear mixed effect models...
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Transcriptome Sequencing of CeRNA Network Constructing in Status Epilepticus Mice Treated by Low-Frequency Repetitive Transcranial Magnetic Stimulation
It is shown that great progress was recently made in the treatment of repetitive transcranial magnetic stimulation (rTMS) for neurological and...
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Interaction between color and attentional level in children’s conflict control
Perception of color can affect cognition and behavior in humans. Although there has been increasing interest in the effect of red on cognitive...
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Environmental signals perceived by the brain abate pro-metastatic monocytes by dampening glucocorticoids receptor signaling
While positive social-behavioral factors predict longer survival in cancer patients, the underlying mechanisms are unknown. Since tumor metastasis...
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Considering the Effects of Modern Point-of-Care Urine Biomarker Assays in Follow-Up of Patients with High-Risk Non-muscle-Invasive Bladder Cancer
Background: Although a plethora of urine markers for diagnosis and follow-up of patients with bladder cancer (BC) has been developed and studied, the... -
Identification and molecular characterization of a novel kudzu-infecting virus of the family Betaflexiviridae
A new virus, tentatively named “kudzu virus D” (KuVD) was discovered in kudzu ( Pueraria montana var. lobata ) in South Korea. Its complete genome...
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Automatic Cobb angle measurement method based on vertebra segmentation by deep learning
The accuracy of the Cobb measurement is essential for the diagnosis and treatment of scoliosis. Manual measurement is however influenced by the...
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Segmentation of retinal vessels in fundus images based on U-Net with self-calibrated convolutions and spatial attention modules
Automated and accurate segmentation of retinal vessels in fundus images is an important step for screening and diagnosing various ophthalmologic...
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Effects of super-enhancers in cancer metastasis: mechanisms and therapeutic targets
Metastasis remains the principal cause of cancer-related lethality despite advancements in cancer treatment. Dysfunctional epigenetic alterations are...
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EEG-FMCNN: A fusion multi-branch 1D convolutional neural network for EEG-based motor imagery classification
Motor imagery (MI) electroencephalogram (EEG) signal is recognized as a promising paradigm for brain-computer interface (BCI) systems and has been...
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Selenium Neuroprotection in Neurodegenerative Disorders
Selenium (Se) is an essential element, and severe deficiency of Se is incompatible with human life. Se is part of a restricted group of 25 proteins,... -
IL-6 production through repression of UBASH3A gene via epigenetic dysregulation of super-enhancer in CD4+ T cells in rheumatoid arthritis
BackgroundRheumatoid arthritis (RA) is associated with immune dysfunction. UBASH3A as a negative regulator of T cell receptors (TCRs) signaling is a...
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A multi-task deep learning model for EGFR genoty** prediction and GTV segmentation of brain metastasis
BackgroundThe precise prediction of epidermal growth factor receptor (EGFR) mutation status and gross tumor volume (GTV) segmentation are crucial...
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The TLR4 agonist adjuvant SLA-SE promotes functional mucosal antibodies against a parenterally delivered ETEC vaccine
Many pathogens establish infection at mucosal surfaces such as the enteric pathogen Enterotoxigenic E. coli (ETEC). Thus, there is a pressing need...
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Laterality Index Calculations in a Control Study of Functional Near Infrared Spectroscopy
Hemispheric dominance has been used to understand the influence of central and peripheral neural damage on the motor function of individuals with...
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Are medication effects on subjective response to alcohol and cue-induced craving associated? A meta regression study
RationaleAlcohol administration and cue-reactivity paradigms are frequently used to screen for the initial efficacy of medications for alcohol use...
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Cis-acting super-enhancer lncRNAs as biomarkers to early-stage breast cancer
BackgroundIncreased breast cancer screening over the past four decades has led to a substantial rise in the diagnosis of ductal carcinoma in situ...
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Regional differences in the ultrastructure of mucosal macrophages in the rat large intestine
We previously clarified the histological characteristics of macrophages in the rat small intestine using serial block-face scanning electron...
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IEM-1925, a Glutamate Receptor Channel Blocker, Increases the Latent Period and Decreases the Duration of Status Epilepticus in Rats in a Lithium-Pilocarpine Model of Epilepsy
Chronic experiments on male Wistar and Krushinskii–Molodkina rats, the latter having an inherited predisposition for audiogenic convulsions,...
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The effects of auditory consequences on visuomotor adaptation and motor memory
Sensorimotor adaptation is a form of motor learning that is essential for maintaining motor performance across the lifespan and is integral to...