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Biomarkers of malignant transformation in oral leukoplakia: from bench to bedside
Oral leukoplakia is a common precursor lesion of oral squamous cell carcinoma, which indicates a high potential of malignancy. The malignant...
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Intratumoral in vivo staging of breast cancer by multi-tracer PET and advanced analysis
The staging and local management of breast cancer involves the evaluation of the extent and completeness of excision of both the invasive carcinoma...
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Deep learning model for classifying endometrial lesions
BackgroundHysteroscopy is a commonly used technique for diagnosing endometrial lesions. It is essential to develop an objective model to aid...
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Detection of HPV RNA molecules in stratified mucin-producing intraepithelial lesion (SMILE) with concurrent cervical intraepithelial lesion: a case report
BackgroundStratified mucin-producing intraepithelial lesion (SMILE) is a rare precursor lesion in the uterine cervix that is considered a variant of...
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CD98hc has a pivotal role in maintaining the immuno-barrier integrity of basal layer cells in esophageal epithelium
ObjectivesThe current study aims to find the linker between esophageal epithelial carcinogenesis and chronic inflammation and the origin of...
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Tumor Microenvironment
In this chapter, we will learn that the tumor microenvironment is a stroma of normal cells supporting cancer cells. Tumors act like parasites that...
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SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice and aggressive gastric cancer in humans
BackgroundSolute carrier family 26 member (SLC26A9) is a Cl − uniporter with very high expression levels in the gastric mucosa. Here, we describe...
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Temporal and spatial characteristics of tumor evolution in a mouse model of oral squamous cell carcinoma
ObjectivesWe aimed to elucidate the temporal and spatial characteristics of tumor evolution in an oral squamous cell carcinoma (OSCC) mouse model...
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Li Fraumeni Syndrome predisposes to gastro-esophageal junction tumours
Li-Fraumeni Syndrome (LFS), caused by germline pathogenic variants in TP53 , predisposes to a wide range of young-onset malignancies, particularly...
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Discovery and technical validation of high-performance methylated DNA markers for the detection of cervical lesions at risk of malignant progression in low- and middle-income countries
BackgroundCervical cancer remains a leading cause of death, particularly in develo** countries. WHO screening guidelines recommend human papilloma...
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A deep-learning algorithm to classify skin lesions from mpox virus infection
Undetected infection and delayed isolation of infected individuals are key factors driving the monkeypox virus (now termed mpox virus or MPXV)...
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Breast cancer risk in premalignant lesions: osteopontin splice variants indicate prognosis
BackgroundPremalignant breast lesions pose variable risks for transformation, raising the question who should receive treatment to counteract the...
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Skin Cancer: Prevention and Early Detection
Melanoma and non-melanoma skin cancers are one of the most common cancers prevalent in white-skinned populations, and its rising incidence and...
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Development and validation of a multivariable model for prediction of malignant transformation and recurrence of oral epithelial dysplasia
BackgroundOral epithelial dysplasia (OED) is the precursor to oral squamous cell carcinoma which is amongst the top ten cancers worldwide. Prognostic...
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Risk Factors of Oral Cancer: Identification and Mechanism of Prevention
Background: Oral cancer is a serious public health problem. Unfortunately, most cases are diagnosed in advanced stages and consequently have a poor...
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Serum methylation of GALNT9, UPF3A, WARS, and LDB2 as noninvasive biomarkers for the early detection of colorectal cancer and advanced adenomas
BackgroundEarly detection has proven to be the most effective strategy to reduce the incidence and mortality of colorectal cancer (CRC)....
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Dormant cancer cells: programmed quiescence, senescence, or both?
Metastasis is the overwhelming driver of cancer mortality, accounting for the majority of cancer deaths. Many patients present with metastatic...
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Immediate histologic correlation in patients with different HPV genotypes and ages: a single center analysis in China
BackgroundHuman papillomavirus (HPV) has been confirmed as a major causative factor for malignant transformation of cervical epithelial cells and for...
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