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Effects of the Maternal Environment on Early Postnatal Development in OXYS Rats
Changes in the environment of the embryo during intrauterine development can affect the postnatal ontogeny of offspring. We report here studies using...
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Lrig1 expression identifies quiescent stem cells in the ventricular-subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation
BackgroundWe previously identified Leucine-rich repeats and immunoglobulin-like domains 1 ( Lrig1 ) as a marker of long-term neurogenic stem cells in...
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The Effect of Glutathione Deficit During Early Postnatal Brain Development on the Prepulse Inhibition and Monoamine Levels in Brain Structures of Adult Sprague–Dawley Rats
Recent studies suggest that impaired glutathione synthesis and distorted dopaminergic transmission are important factors in the pathophysiology of...
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The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development
DNA methyltransferase 3a (DNMT3A) plays a crucial role during mammalian development. Two isoforms of DNMT3A are differentially expressed from stem...
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Assessment of Ante- and Postnatal Development of the Offspring of Male Rats Crossed in Delayed Periods after Treatment with Methotrexate in Low Doses
We studied ante- and postnatal development of the offspring of intact female rats crossed with males injected with low doses of methotrexate 3 and 6...
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Genetics of human brain development
Brain development in humans is achieved through precise spatiotemporal genetic control, the mechanisms of which remain largely elusive. Recently,...
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Zika virus vertical transmission in interferon receptor1-antagonized Rag1−/− mice results in postnatal brain abnormalities and clinical disease
The mechanisms by which vertically transmitted Zika virus (ZIKV) causes postnatal brain development abnormalities and congenital disease remain...
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General Brain Development
Basic knowledge about the prenatal development of the human brain in general, the brainstem and the cranial nerve-innervated structures of head and...
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Maternal e-cigarette use can disrupt postnatal blood-brain barrier (BBB) integrity and deteriorates motor, learning and memory function: influence of sex and age
Electronic nicotine delivery systems (ENDS), also commonly known as electronic cigarettes (e-cigs) are considered in most cases as a safer...
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Peroxisomes during postnatal development of mouse endocrine and exocrine pancreas display cell-type- and stage-specific protein composition
Peroxisomal dysfunction unhinges cellular metabolism by causing the accumulation of toxic metabolic intermediates (e.g. reactive oxygen species, very...
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Alloparental Care and Postnatal Development of Heterozygous TPH2 Transgenic Mice
AbstractThe issue of the relationship between the transmission of a negative effect from a depressed mother to her offspring is one of the priorities...
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Adropin, a novel hepatokine: localization and expression during postnatal development and its impact on testicular functions of pre-pubertal mice
Adropin, a multifaceted peptide, was identified as a new metabolic hormone responsible for regulating gluco-lipid homeostasis. However, its role in...
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REST in the Road Map of Brain Development
Repressor element-1 silencing transcription factor (REST) or also known as neuron-restrictive silencing factor (NRSF), is the key initiator of...
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Brain macrophage development, diversity and dysregulation in health and disease
Brain macrophages include microglia in the parenchyma, border-associated macrophages in the meningeal-choroid plexus-perivascular space, and...
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Sha** the brain vasculature in development and disease in the single-cell era
The CNS critically relies on the formation and proper function of its vasculature during development, adult homeostasis and disease. Angiogenesis —...
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Development of myelin in fetal and postnatal neocortex of the pig, the European wild boar Sus scrofa
Myelination of the neocortex of altricial species is mostly a postnatal event, and the appearance of myelin has been associated with the end of the...
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Formation of the Looming-evoked Innate Defensive Response during Postnatal Development in Mice
Environmental threats often trigger innate defensive responses in mammals. However, the gradual development of functional properties of these...
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Down-regulation of the brain-specific cell-adhesion molecule contactin-3 in tuberous sclerosis complex during the early postnatal period
BackgroundThe genetic disorder tuberous sclerosis complex (TSC) is frequently accompanied by the development of neuropsychiatric disorders, including...
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Effects of lipopolysaccharide administration at different postnatal periods on behavioral and biochemical assessments in Wistar rats
Rodent model systems using lipopolysaccharide (LPS) administration have been developed to examine the effect of postnatal inflammation on...
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Intrauterine inflammation and postnatal intravenous dopamine alter the neurovascular unit in preterm newborn lambs
BackgroundIntrauterine inflammation is considered a major cause of brain injury in preterm infants, leading to long-term neurodevelopmental deficits....
