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Fluoropyrimidine type, patient age, tumour sidedness and mutation status as determinants of benefit in patients with metastatic colorectal cancer treated with EGFR monoclonal antibodies: individual patient data pooled analysis of randomised trials from the ARCAD database
BackgroundKRAS mutations in metastatic colorectal cancer (mCRC) are used as predictive biomarkers to select therapy with EGFR monoclonal antibodies...
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The impact of anthracyclines in intermediate and high-risk HER2-negative early breast cancer—a pooled analysis of the randomised clinical trials PlanB and SUCCESS C
BackgroundAnthracycline/cyclophosphamide-taxane-containing chemotherapy (AC-T) is the standard of care in the adjuvant treatment of HER2-negative...
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Neuroendocrine pathways and breast cancer progression: a pooled analysis of somatic mutations and gene expression from two large breast cancer cohorts
BackgroundExperimental studies indicate that neuroendocrine pathways might play a role in progression of breast cancer. We aim to test the hypothesis...
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Salt intake and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project
PurposePrevious studies show that consuming foods preserved by salting increases the risk of gastric cancer, while results on the association between...
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Association between concomitant proton pump inhibitor use and survival of patients with metastatic prostate cancer receiving abiraterone acetate: a post-hoc analysis of pooled data from three randomized controlled trials
BackgroundEvidence suggests proton pump inhibitor (PPI) use may attenuate the effect of abiraterone acetate plus prednisone (AAP) in metastatic...
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The future burden of oesophageal and stomach cancers attributable to modifiable behaviours in Australia: a pooled cohort study
BackgroundWe quantified the individual and joint contribution of contemporaneous causal behavioural exposures on the future burden of oesophageal and...
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Novel application of one-step pooled molecular testing and maximum likelihood approaches to estimate the prevalence of malaria parasitaemia among rapid diagnostic test negative samples in western Kenya
BackgroundDetection of malaria parasitaemia in samples that are negative by rapid diagnostic tests (RDTs) requires resource-intensive molecular...
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Chemotherapy-induced neutropenia and treatment efficacy in advanced non-small-cell lung cancer: a pooled analysis of 6 randomized trials
BackgroundChemotherapy-induced neutropenia (CIN) has been demonstrated to be a prognostic factor in several cancer conditions. We previously found a...
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Carboplatin versus cisplatin in combination with etoposide in the first-line treatment of small cell lung cancer: a pooled analysis
BackgroundExtensive-stage small cell lung cancer (ES-SCLC) is an aggressive disease with poor survival, and platinum-etoposide chemotherapy is...
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Feasibility and safety of EGFR-TKI neoadjuvant therapy for EGFR-mutated NSCLC: A meta-analysis
BackgroundThe role of neoadjuvant epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) targeted therapy for EGFR-mutated non-small...
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Prenatal Genome-Wide Sequencing analysis (Exome or Genome) in detecting pathogenic Single Nucleotide Variants in fetal Central Nervous System Anomalies: systematic review and meta-analysis
Prenatal Exome (pES) or Genome (pGS) Sequencing analysis showed a significant incremental diagnostic yield over karyotype and chromosomal microarray...
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Pooled analysis of combination antiemetic therapy for chemotherapy-induced nausea and vomiting in patients with colorectal cancer treated with oxaliplatin-based chemotherapy of moderate emetic risk
BackgroundAmong patients with colorectal cancer (CRC) treated with oxaliplatin (L-OHP)-based chemotherapy, delayed chemotherapy-induced nausea and...
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Pooled Map** of Quantitative Trait Loci Conferring Heat Tolerance at Seedling Stage in Rice (Oryza sativa L.)
Global warming threatens human life on many aspects, including heat stress on crop production. Breeding heat-tolerant varieties is a fundamental way...
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Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort: the ELAPSE project
BackgroundThe evidence linking ambient air pollution to bladder cancer is limited and mixed.
MethodsWe assessed the associations of bladder cancer...
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The prevalence of vancomycin-resistant Staphylococcus aureus in Ethiopia: a systematic review and meta-analysis
IntroductionVancomycin-resistant Staphylococcus aureus , identified as a “high priority antibiotic-resistant pathogen” by the World Health...
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Psychological Distress Impact of Coronavirus Disease (COVID-19) Outbreak on Three Continents: A Systematic Review and Meta-analysis
Background: The dire state of coronavirus disease (COVID-19) outbreak has had a substantial psychological impact on society. Methods: A systematic...
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Prevalence of beta thalassemia carriers in India: a systematic review and meta-analysis
A large number of studies have reported that the prevalence of beta thalassemia carriers in India varies by ethnic groups. The objective of this...
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Clinical accuracy of instrument-based SARS-CoV-2 antigen diagnostic tests: a systematic review and meta-analysis
BackgroundDuring the COVID-19 pandemic, antigen diagnostic tests were frequently used for screening, triage, and diagnosis. Novel instrument-based...
