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Plasmodium: Vertebrate Host
Plasmodium spp. infection remains as a major global health problem, being annually responsible for a large number of deaths. Disease eradication...
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Ecology of asynchronous asexual replication: the intraerythrocytic development cycle of Plasmodium berghei is resistant to host rhythms
BackgroundDaily periodicity in the diverse activities of parasites occurs across a broad taxonomic range. The rhythms exhibited by parasites are...
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Analysis of spleen histopathology, splenocyte composition and haematological parameters in four strains of mice infected with Plasmodium berghei K173
BackgroundMalaria is a fatal disease that presents clinically as a continuum of symptoms and severity, which are determined by complex host-parasite...
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Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS
ObjectiveTo analyse the transcriptional profiles of the pir multigene family of Plasmodium chabaudi chabaudi in male and female gametocytes isolated...
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Concomitant experimental coinfection by Plasmodium berghei NK65-NY and Ascaris suum downregulates the Ascaris-specific immune response and potentiates Ascaris-associated lung pathology
BackgroundAscariasis and malaria are highly prevalent parasitic diseases in tropical regions and often have overlap** endemic areas, contributing...
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Antimalarial activity and biochemical effects of saponin-rich extract of Dianthus basuticus Burtt Davy in Plasmodium berghei-infected mice
Saponin extract from Dianthus basuticus (SEDB), was investigated for its anti-malarial activity and biochemical effects in Plasmodium berghei -infected...
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Enzymes of Isoprenoid Biosynthesis and Control of Malarial Parasite Plasmodium falciparum
There is high importance for the control of parasite Plasmodium falciparum which is responsible for causing malaria. Following the classical...
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Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside
BackgroundTargeting the asymptomatic liver stage of Plasmodium infection through chemoprevention could become a key intervention to reduce...
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Tetrorchidium didymostemon leaf extract reduces Plasmodium berghei induced oxidative stress and hepatic injury in Swiss albino mice
Oxidative stress, already implicated in malaria infection has been identified as one of the major contributors to the pathophysiology of malaria....
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Targeting Apicoplasts in Plasmodium falciparum, Origin and Pathways
The apicoplast is an important source of antimalarial drug target. The in-depth evaluation and examination showed that apicoplast is a potent...
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Cellular and Molecular Interactions of Plasmodium with Mosquito Vectors
Malaria is one of the most common vector-borne diseases prevalent in tropical and subtropical areas of the world and is considered a significant...
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Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparum
Over the past thirty years, epigenetic regulation of gene expression has gained increasing interest as it was shown to be implicated in illnesses...
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Xylopic acid-amodiaquine and xylopic acid-artesunate combinations are effective in managing malaria in Plasmodium berghei-infected mice
BackgroundEvidence of Plasmodium resistance to some of the current anti-malarial agents makes it imperative to search for newer and effective drugs...
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Does vitamin D reduce the mortality rate of Plasmodium infection?: a systematic review and meta-analysis
BackgroundVitamin D supplementation is recommended as an effective adjunct to counteract malaria pathogenesis, but the evidence on this point is...
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An Overview on the Impact of Microbiota on Malaria Transmission and Severity: Plasmodium–Vector–Host Axis
PurposeMalaria, which is a vector-borne disease caused by Plasmodium sp., continue to become a serious threat, causing more than 600,000 deaths...
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Decoquinate liposomes: highly effective clearance of Plasmodium parasites causing severe malaria
BackgroundSevere malaria caused by Plasmodium falciparum leads to most malaria-related deaths globally. Decoquinate (DQ) displays strong activity...
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Role of Plasmodium berghei ookinete surface and oocyst capsule protein, a novel oocyst capsule-associated protein, in ookinete motility
BackgroundPlasmodium sp., which causes malaria, must first develop in mosquitoes before being transmitted. Upon ingesting infected blood, gametes...
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Size-dependent enhancement of gene expression by Plasmodium 5’UTR introns
BackgroundEukaryotic genes contain introns that are removed by the spliceosomal machinery during mRNA maturation. Introns impose a huge energetic...
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A screen for Plasmodium falciparum sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host–pathogen interactions
BackgroundSporozoite invasion of hepatocytes is an essential step in the Plasmodium life-cycle and has similarities, at the cellular level, to...
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The Metabolomic Profiles of Sera of Mice Infected with Plasmodium berghei and Treated by Effective Fraction of Naja naja oxiana Using 1H Nuclear Magnetic Resonance Spectroscopy
BackgroundThe use of venom fractions from the Iranian cobra could be useful adjunct treatments of malaria with chloroquine. A metabolomic...
