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Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy
The human placenta has a vital role in ensuring a successful pregnancy. Despite the growing body of knowledge about its cellular compositions and...
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Placental DNA methylation profile as predicting marker for autism spectrum disorder (ASD)
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that impairs normal brain development and socio-cognitive abilities. The pathogenesis...
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Subunit nanovaccine elicited T cell functional activation controls Trypanosoma cruzi mediated maternal and placental tissue damage and improves pregnancy outcomes in mice
This study investigated a candidate vaccine effect against maternal Trypanosoma cruzi (Tc) infection and improved pregnancy outcomes. For this, TcG2 ...
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Edaravone Confers Neuroprotective, Anti-inflammatory, and Antioxidant Effects on the Fetal Brain of a Placental-ischemia Mouse Model
Reduced uterine perfusion pressure (RUPP) is a well-established model which mimics many clinical features of preeclampsia (PE). Edaravone is a free...
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Aberrant hypomethylation at imprinted differentially methylated regions is involved in biparental placental mesenchymal dysplasia
BackgroundPlacental mesenchymal dysplasia (PMD) is a morphological abnormality resembling partial hydatidiform moles. It is often associated with...
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Placental extract suppresses lipid droplet accumulation by autophagy during the differentiation of adipose-derived mesenchymal stromal/stem cells into mature adipocytes
ObjectivePlacental extract, which contains various bioactive compounds, has been used as traditional medicine. Many studies have demonstrated...
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Fetal growth at term and placental oxidative stress in a tissue micro-array model: a histological and immunohistochemistry study
This study examines 8-hydroxyguanine (8-oxo-Gua) staining in placental tissue samples based on fetal size at birth as well as its relationships with...
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Placental transcriptome analysis of hypertensive pregnancies identifies distinct gene expression profiles of preeclampsia superimposed on chronic hypertension
BackgroundThe pathogenesis of preeclampsia superimposed on chronic hypertension (SI) is poorly understood relative to preeclampsia (PreE) occurring...
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Placental-fetal distribution of carbon particles in a pregnant rabbit model after repeated exposure to diluted diesel engine exhaust
BackgroundAirborne pollution particles have been shown to translocate from the mother’s lung to the fetal circulation, but their distribution and...
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Alternative Splicing Landscape of Placental Decidual Cells during Physiological Pregnancy
AbstractAlternative splicing (AS) of RNA is a key step in the post-transcriptional regulation of gene expression. It provides transcriptional...
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Identification of novel cell-free RNAs in maternal plasma as preterm biomarkers in combination with placental RNA profiles
BackgroundPreterm birth (PTB) is the main driver of newborn deaths. The identification of pregnancies at risk of PTB remains challenging, as the...
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Morphometric Parameters of Placental Villi in Parturient Women with COVID-19
We performed a comparative morphological analysis of placental villi in parturient women with mild and moderate COVID-19 infection. The area and...
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Placental endocrine function shapes cerebellar development and social behavior
Compromised placental function or premature loss has been linked to diverse neurodevelopmental disorders. Here we show that placenta allopregnanolone...
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Role of Synbiotics in Reproductive Disorders
It has been discovered that the reproductive tract contains microbial communities, and this stable microbiome contributes to the preservation of...
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Tanshinone IIA increased amniotic fluid volume through down-regulating placental AQPs expression via inhibiting the activity of GSK-3β
The mechanism of idiopathic oligohydramnios is still uncertain, and there is no effective and targeted treatment for it. Placental aquaporins (AQPs)...
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Interactions Between Extracellular Vesicles and Autophagy in Neuroimmune Disorders
Neuroimmune disorders, such as multiple sclerosis, neuromyelitis optica spectrum disorder, myasthenia gravis, and Guillain–Barré syndrome, are...
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Flavivirus replication kinetics in early-term placental cell lines with different differentiation pathways
BackgroundThe uncontrollable spread of Zika virus (ZIKV) in the Americas during 2015–2017, and its causal link to microcephaly in newborns and...
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Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation
BackgroundGlucocorticoids (GCs) play a pivotal role in fetal programming. Antenatal treatment with synthetic GCs (sGCs) in individuals in danger of...
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Comparative Characteristics of the Expression of Fucosylated Glycans and Morphometric Parameters of Terminal Placental Villi Depending on the Severity of Preeclampsia
We performed a comparative analysis of the expression of fucosylated glycans and morphometric characteristics of the terminal villi of the placenta,...
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Fetal growth, fetal development, and placental features in women with polycystic ovary syndrome: analysis based on fetal and placental magnetic resonance imaging
Objective: Polycystic ovary syndrome (PCOS), a common endocrine-metabolic dysfunction in reproductiveaged women, may be involved in compromised...