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Piezo1 promoted hepatocellular carcinoma progression and EMT through activating TGF-β signaling by recruiting Rab5c
BackgroundPiezo1 has been revealed to play a regulatory role in vascular development and progression of variety tumors. However, whether and how the...
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Somatosensation
The somatosensory system enables organisms to feel, to ache, to chill, and, perhaps most importantly, to know which parts of the body are involved in...
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Microglial amyloid beta clearance is driven by PIEZO1 channels
BackgroundMicroglia are the endogenous immune cells of the brain and act as sensors of pathology to maintain brain homeostasis and eliminate...
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Expression of the relaxin family peptide 4 receptor by enterochromaffin cells of the mouse large intestine
The gastrointestinal hormone, insulin-like peptide 5 (INSL5), is found in large intestinal enteroendocrine cells (EEC). One of its functions is to...
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Neural signalling of gut mechanosensation in ingestive and digestive processes
Eating and drinking generate sequential mechanosensory signals along the digestive tract. These signals are communicated to the brain for the timely...
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Navigating the neuroinflammatory network: insights from diverse cell models
In this Highlights article, we present insights into the use of simple cell lines in neuroinflammation research, highlighting key findings from our...
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Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors
With swee** advances in precision delivery systems and manipulation of the genomes and transcriptomes of various cell types, medical biotechnology...
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The renin angiotensin aldosterone system
In this review, we will cover (i) the proteolytic cascade of the RAAS, (ii) its regulation by multiple feedback-controlled parameters, and (iii) the...
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Optogenetic Manipulation of the Vagus Nerve
The vagus nerve plays a pivotal role in communication between the brain and peripheral organs involved in the sensory detection and the autonomic...
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Therapeutic Potential of Combinative shRNA-Encoded Lentivirus-Mediated Gene Silencing to Accelerate Somatosensory Recovery After Spinal Cord Trauma
Neuropathic pain following spinal cord injury (SCI) remains a difficult problem that affects more than 80% of SCI patients. Growing evidence...
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Patch-seq: Advances and Biological Applications
Multimodal analysis of gene-expression patterns, electrophysiological properties, and morphological phenotypes at the single-cell/single-nucleus...
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GPCRs Under Flow and Pressure
G protein-coupled receptors (GPCRs) are commonly known as membrane-bound cellular sensors for chemical stimuli like small molecules and hormones that...
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A vagal–brainstem interoceptive circuit for cough-like defensive behaviors in mice
Coughing is a respiratory behavior that plays a crucial role in protecting the respiratory system. Here we show that the nucleus of the solitary...
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Somatosensation
The somatosensory system enables organisms to feel, to ache, to chill, and, perhaps most importantly, to know which parts of the body are involved in...
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The urothelium: a multi-faceted barrier against a harsh environment
All mucosal surfaces must deal with the challenge of exposure to the outside world. The urothelium is a highly specialized layer of stratified...
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Interoceptive rhythms in the brain
Sensing internal bodily signals, or interoception, is fundamental to maintain life. However, interoception should not be viewed as an isolated...
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RNA sequencing and functional studies of patient-derived cells reveal that neurexin-1 and regulators of this pathway are associated with poor outcomes in Ewing sarcoma
PurposeThe development of biomarkers and molecularly targeted therapies for patients with Ewing sarcoma (ES) in order to minimise morbidity and...
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Capsazepine decreases corneal pain syndrome in severe dry eye disease
BackgroundDry eye disease (DED) is a multifactorial disease of the ocular surface accompanied by neurosensory abnormalities. Here, we evaluated the...
