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Restriction-Free Construction of a Phage-Presented Very Short Macrocyclic Peptide Library
Phage display is a commonly used technology for the screening of large clonal libraries of proteins and peptides. The construction of peptide...
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Cell-penetrating porcine single-chain antibodies (transbodies) against nonstructural protein 1β (NSP1β) of porcine reproductive and respiratory syndrome virus inhibit virus replication
Porcine reproductive and respiratory syndrome virus (PRRSV) causes porcine reproductive and respiratory syndrome (PRRS) worldwide, especially in...
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Structure of a VHH isolated from a naïve phage display library
ObjectiveTo determine the X-ray structure and biophysical properties of a Camelid V H H isolated from a naïve phage display library.
Results ...
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Development of a neutralization monoclonal antibody with a broad neutralizing effect against SARS-CoV-2 variants
BackgroundThe emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has challenged the effectiveness of current...
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Antibody Display Systems
Antibodies are promising tools for biomedical applications. With respect to functionality, scientists nowadays have a plethora of options to...
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A novel PDPN antagonist peptide CY12-RP2 inhibits melanoma growth via Wnt/β-catenin and modulates the immune cells
BackgroundPodoplanin (PDPN) is a highly conserved, mucin-type protein specific to the lymphatic system. Overexpression of PDPN is associated with the...
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Selection of Antibody Fragments for CAR-T Cell Therapy from Phage Display Libraries
CAR-T cell therapy emerged in the last years as a great promise to cancer treatment. Nowadays, there is a run to improve the breadth of its use, and...
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High throughput sequencing provides exact genomic locations of inducible prophages and accurate phage-to-host ratios in gut microbial strains
BackgroundTemperate phages influence the density, diversity and function of bacterial populations. Historically, they have been described as carriers...
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A structure and knowledge-based combinatorial approach to engineering universal scFv antibodies against influenza M2 protein
BackgroundThe influenza virus enters the host via hemagglutinin protein binding to cell surface sialic acid. Receptor-mediated endocytosis is...
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Bacteriophage-Based Biosensors: Detection of Bacteria and Beyond
Pathogenic infections cause tremendous health threats and socioeconomic burdens worldwide. Conventional methods for bacteria detection are laborious,...
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BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer
BackgroundBrother of regulator of imprinted sites (BORIS) is expressed in most cancers and often associated with short survival and poor prognosis in...
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Nanobody-armed T cells endow CAR-T cells with cytotoxicity against lymphoma cells
BackgroundTaking advantage of nanobodies (Nbs) in immunotherapy, we investigated the cytotoxicity of Nb-based chimeric antigen receptor T cells (Nb...
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T cell-redirecting antibody for treatment of solid tumors via targeting mesothelin
T cell engaging bispecific antibodies (TCBs) have recently become significant in cancer treatment. In this study we developed MSLN490, a novel TCB...
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Synthetic polypeptide crotamine: characterization as a myotoxin and as a target of combinatorial peptides
AbstractCrotamine is a rattlesnake-derived toxin that causes fast-twitch muscle paralysis. As a cell-penetrating polypeptide, crotamine has been...
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Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology
BackgroundChimeric antigen receptor T (CAR-T) cell therapy, as an emerging anti-tumor treatment, has garnered extensive attention in the study of...
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A high affinity and specificity anti-HER2 single-domain antibody (VHH) that targets trastuzumab’s epitope with versatile biochemical, biological, and medical applications
In the past decade, various single-domain antibodies from llamas, also known as VHH or nanobody, have been discovered with applications in tumor...
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Development of therapeutic antibodies for the treatment of diseases
Since the first monoclonal antibody drug, muromonab-CD3, was approved for marketing in 1986, 165 antibody drugs have been approved or are under...
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Collagen-binding peptides for the enhanced imaging, lubrication and regeneration of osteoarthritic articular cartilage
Treatments for osteoarthritis would benefit from the enhanced visualization of injured articular cartilage and from the targeted delivery of...
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Bacteriophages in Nanotechnology: History and Future
Bacteriophage (phage) proteins and whole phage particles are being used in the development of new functional materials with nanoscale features....
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Monoclonal antibodies against S2 subunit of spike protein exhibit broad reactivity toward SARS-CoV-2 variants
BackgroundThe variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) harbor diverse spike (S) protein sequences, which can greatly...
