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Stress-induced impairment in fear discrimination is causally related to increased kynurenic acid formation in the prefrontal cortex
RationaleStress is related to cognitive impairments which are observed in most major brain diseases. Prior studies showed that the brain...
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Functional connectivity patterns in parosmia
ObjectiveParosmia is a qualitative olfactory dysfunction presenting as “distorted odor perception” in presence of an odor source. Aim of this study...
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Olfactory Dysfunction in Schizophrenia: Evaluating Olfactory Abilities Across Species
Though understudied relative to perturbations in the auditory and visual domains, olfactory dysfunction is a common symptom of schizophrenia. Over...
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Whitening of odor representations by the wiring diagram of the olfactory bulb
Neuronal computations underlying higher brain functions depend on synaptic interactions among specific neurons. A mechanistic understanding of such...
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Differences in olfactory habituation between orthonasal and retronasal pathways
The odorant arrives at nasal olfactory epithelium ortho- and retronasally. This experiment aimed to study the potential different olfactory...
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Predictive value of abbreviated olfactory tests in prodromal Parkinson disease
There is disagreement in the literature whether olfaction may show specific impairments in Parkinson Disease (PD) and if olfactory tests comprised of...
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Amelioration of Cognitive and Olfactory System Deficits in APOE4 Transgenic Mice with DHA Treatment
Olfactory dysfunction and atrophy of olfactory brain regions are observed early in mild cognitive impairment and Alzheimer disease. Despite...
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Olfactory Response to Altitude Hypoxia: A Pilot Study During a Himalayan Trek
The adaptation of olfaction to extreme environments is an area of limited understanding. This study aimed to get insights into the factors that...
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Prenatal Hypoxia Impairs Olfactory Function in Postnatal Ontogeny in Rats
Analysis of the age-related dynamics of olfactory behavior in the odor preference and food search testsshowed that all male Wistar rats, regardless...
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Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice
The prefrontal cortex (PFC) is implicated in processing of the affective state of others through non-verbal communication. This social cognitive...
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Sex-specific modulation of early life vocalization and cognition by Fmr1 gene dosage in a mouse model of Fragile X Syndrome
BackgroundPup-dam ultrasonic vocalizations (USVs) are essential to cognitive and socio-emotional development. In autism and Fragile X Syndrome (FXS),...
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α-Synuclein aggregation in the olfactory bulb induces olfactory deficits by perturbing granule cells and granular–mitral synaptic transmission
Olfactory dysfunction is an early pre-motor symptom of Parkinson’s disease (PD) but the neural mechanisms underlying this dysfunction remain largely...
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An fMRI-based investigation of the effects of odors on the functional connectivity network underlying the working memory
In the human brain, the regions responsible for emotion processing, motivation, and memory are heavily influenced by olfaction, whose neural pathway...
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A specific olfactory cortico-thalamic pathway contributing to sampling performance during odor reversal learning
A growing body of evidence shows that olfactory information is processed within a thalamic nucleus in both rodents and humans. The mediodorsal...
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A non-invasive olfactory bulb measure dissociates Parkinson’s patients from healthy controls and discloses disease duration
Olfactory dysfunction is a prevalent non-motor symptom of Parkinson’s disease (PD). This dysfunction is a result of neurodegeneration within the...
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Intrinsic hippocampal connectivity is associated with individual differences in retrospective duration processing
The estimation of incidentally encoded durations of time intervals (retrospective duration processing) is thought to rely on the retrieval of...
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Quantifying the lagged Poincaré plot geometry of ultrashort heart rate variability series: automatic recognition of odor hedonic tone
The application of Poincaré plot analysis to characterize inter-beat interval dynamics has been successfully proposed in the scientific literature...
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Stimulus mediation, specificity and impact of menthol in rats trained to discriminate puffs of nicotine e-cigarette aerosol from nicotine-free aerosol
RationaleIt is unclear if e-cigarettes have reduced abuse liability relative to traditional cigarettes, especially when considering advanced devices...
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Assessment of Olfactory Toxicity in Rodents
This chapter focuses on the main olfactory system of rodents that is used to detect small molecules. The olfactory system begins with sensory...
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Characterization of pathological changes in the olfactory system of mice exposed to methylmercury
Methylmercury (MeHg) is a well-known environmental neurotoxicant that causes severe brain disorders such as Minamata disease. Although some patients...
