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Drug-Induced Nephrotoxicity and Use of Biomarkers
Nephrotoxicity has been defined as renal injury that is caused due to direct or indirect exposure, mostly to drugs and other exogenous industrial or...
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Protective effects of berberine as a natural antioxidant and anti-inflammatory agent against nephrotoxicity induced by cyclophosphamide in mice
PurposeCyclophosphamide is an alkylating agent with nephrotoxicity that constrains its clinical application. Berberine is an isoquinoline derivative...
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Blood Count Profiles as Biomarkers in Burns: Red Cells, Platelets, and Beyond
The search for biomarkers that help physicians in medical practice has been a topic of great interest in the last decades. Burned patients represent...
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Nicotine exacerbates diabetic nephropathy through upregulation of Grem1 expression
BackgroundDiabetic nephropathy (DN) is a major complication of diabetes mellitus. Clinical reports indicate that smoking is a significant risk factor...
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PGAM5 exacerbates acute renal injury by initiating mitochondria-dependent apoptosis by facilitating mitochondrial cytochrome c release
Acute kidney injury (AKI) is a worldwide public health problem characterized by the massive loss of tubular cells. However, the precise mechanism for...
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Upregulation of UHRF1 Promotes PINK1-mediated Mitophagy to Alleviates Ferroptosis in Diabetic Nephropathy
Diabetic nephropathy (DN) is a common diabetic complication. Studies show that mitophagy inhibition induced-ferroptosis plays a crucial role in DN...
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Lipocalin 2—not only a biomarker: a study of current literature and systematic findings of ongoing clinical trials
Lipocalin 2 (Lcn2), also known as neutrophil gelatinase–associated lipocalin, is an innate immune protein encoded by the LCN2 gene. In this study,...
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Contrast-Induced Nephropathy (CIN) and Biomarkers
Acute kidney injury (AKI) is a sudden loss of kidney function secondary to a variety of reasons. Contrast-induced nephropathy (CIN) is a form of AKI...
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Blunt Abdomen Trauma and Biomarkers
Blunt abdomen trauma (BAT) consists of one of the major emergencies that can result in a wide range of severity from mild simple stable to...
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Migration Stimulating Factor (MSF): Its Role in the Tumour Microenvironment
Migration Stimulating Factor (MSF) is a 70 kDa truncated isoform of fibronectin (FN); its mRNA is generated from the FN gene by an unusual two-stage...
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Biomarkers of Diabetes-Induced Nephropathy
Diabetic nephropathy (DN) is the leading cause of end stage renal disease. Therefore, the assessment of renal function and early diagnosis of...
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Immunoglobulin G Is a Novel Substrate for the Endocytic Protein Megalin
Therapeutic immunoglobulin G (IgG) antibodies comprise the largest class of protein therapeutics. Several factors that influence their overall...
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Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways
BackgroundGlabridin (Glab) is a bioactive component of licorice that can ameliorate diabetes, but its role in diabetic nephropathy (DN) has seldom...
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Drug-Induced Nephrotoxicity and Use of Biomarkers
Nephrotoxicity has been defined as renal injury that is caused due to direct or indirect exposure, mostly to drugs and other exogenous industrial or...
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Protective Effects of Intravenous Magnesium Sulfate in Stroke Patients Receiving Amiodarone: A Randomized Controlled Trial
Anti-arrhythmic agents, like amiodarone, interfere at different stages of the ischemic stroke. However, amiodarone was accompanied with immunological...
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Blood Count Profiles as Biomarkers in Burns: Red Cells, Platelets, and Beyond
The search for biomarkers that help physicians in medical practice has been a topic of great interest in the last decades. Burned patients represent...
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Lipocalin-2-Mediated Insufficient Oligodendrocyte Progenitor Cell Remyelination for White Matter Injury After Subarachnoid Hemorrhage via SCL22A17 Receptor/Early Growth Response Protein 1 Signaling
Insufficient remyelination due to impaired oligodendrocyte precursor cell (OPC) differentiation and maturation is strongly associated with...
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Urinary neutrophil gelatinase-associated lipocalin values alone and combined with Prognostic Index predict septic AKI, DIC, and shock: a pilot study
ObjectiveSepsis is a syndrome involving life-threatening organ dysfunction. The present study aimed to determine whether septic AKI, ARDS, DIC, and...
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Bufalin alleviates acute kidney injury by regulating NLRP3 inflammasome-mediated pyroptosis
BackgroundRecently, there has been an increasing clinical incidence of acute kidney injury (AKI), which rapidly declines renal function and leads to...
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Extracellular Vesicles and Hypertension
Hypertension implicates multiple organs and systems, accounting for the majority of cardiovascular diseases and cardiac death worldwide....