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Predicting the risk of pancreatic cancer in adults with new-onset diabetes: development and internal–external validation of a clinical risk prediction model
BackgroundThe National Institute for Health and Care Excellence (NICE) recommends that people aged 60+ years with newly diagnosed diabetes and weight...
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Development and validation of a machine learning model to predict prognosis in HIV-negative cryptococcal meningitis patients: a multicenter study
PurposeTo predict prognosis in HIV-negative cryptococcal meningitis (CM) patients by develo** and validating a machine learning (ML) model.
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Derivation and validation of a predictive mortality model of in-hospital patients with Acinetobacter baumannii nosocomial infection or colonization
PurposeAcinetobacter baumannii (Ab) is a Gram-negative opportunistic bacterium responsible for nosocomial infections or colonizations. It is...
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Predicting Persistent Aneurysm Filling After Pipeline Embolization Device Treatment in Patients with Intracranial Aneurysm: Development and External Validation of a Nomogram Model
The pipeline embolization device (PED) is an effective endovascular treatment modality for intracranial aneurysm (IA), but nearly one-fifth of IAs...
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Development and validation of a routine blood parameters-based model for screening the occurrence of retinal detachment in high myopia in the context of PPPM
Background/aimsTimely detection and treatment of retinal detachment (RD) could effectively save vision and reduce the risk of progressing visual...
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Establishment and validation of an immune infiltration predictive model for ovarian cancer
BackgroundThe most prevalent mutation in ovarian cancer is the TP53 mutation, which impacts the development and prognosis of the disease. We looked...
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The I-PREDICT 50th Percentile Male Warfighter Finite Element Model: Development and Validation of the Thoracolumbar Spine
Military personnel are commonly at risk of lower back pain and thoracolumbar spine injury. Human volunteers and postmortem human subjects have been...
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Development and external validation of a prediction model for overall survival after resection of distal cholangiocarcinoma
BackgroundVarious prognostic factors are associated with overall survival (OS) after resection of distal cholangiocarcinoma (dCCA). The objective of...
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Bilateral upper extremity trunk model for cross-country sit-skiing double poling propulsion: model development and validation
The subacromial im**ement syndrome is a high-incidence injury for cross-country sit-skiing skier, which is often accompanied by muscle imbalance....
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Development and validation of a preoperative CT‑based radiomics nomogram to differentiate tuberculosis granulomas from lung adenocarcinomas: an external validation study
BackgroundAn accurate and non-invasive approach is urgently needed to distinguish tuberculosis granulomas from lung adenocarcinomas. This study aimed...
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Development and validation of a selenium metabolism regulators associated prognostic model for hepatocellular carcinoma
BackgroundSelenium metabolism has been implicated in human health. This study aimed to identify a selenium metabolism regulator-based prognostic...
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Identification and Validation of Basement Membrane Related LncRNA Signatures as a Novel Prognostic Model for Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a significant cancer with limited treatments and a poor prognosis, with the basement membrane (BM) playing a...
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External Validation of a Vancomycin Population Pharmacokinetic Model and Develo** a New Dosage Regimen in Neonates
Background and ObjectiveVancomycin is the drug of choice in the treatment of MRSA infections. In a published vancomycin population pharmacokinetic...
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PBPK model for antibody disposition in mouse brain: validation using large-pore microdialysis data
The objective of this manuscript was to validate a physiologically-based pharmacokinetic (PBPK) model developed to characterize brain...
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Validation of biomarkers of aging
The search for biomarkers that quantify biological aging (particularly ‘omic’-based biomarkers) has intensified in recent years. Such biomarkers...
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Assessing the performance of QSP models: biology as the driver for validation
Validation of a quantitative model is a critical step in establishing confidence in the model’s suitability for whatever analysis it was designed....
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EMG Validation of a Subject-Specific Thoracolumbar Spine Musculoskeletal Model During Dynamic Activities in Older Adults
Musculoskeletal models can uniquely estimate in vivo demands and injury risk. In this study, we aimed to compare muscle activations from...
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Development of a radiomics model to diagnose pheochromocytoma preoperatively: a multicenter study with prospective validation
BackgroundPreoperative diagnosis of pheochromocytoma (PHEO) accurately impacts preoperative preparation and surgical outcome in PHEO patients. Highly...
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A simulacrum of proliferative vitreoretinopathy (PVR): development and proteomics-based validation of an in vitro model
The epithelial–mesenchymal transition (EMT) is a common feature of disease progression in diseases such as cancer and fibrosis. It is associated with...
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Bioinformatics Identification and Experimental Validation of a Prognostic Model for the Survival of Lung Squamous Cell Carcinoma Patients
Lung squamous cell carcinoma (LUSC) kills more than four million people yearly. Creating more trustworthy tumor molecular markers for LUSC early...
