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Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (mitobiogenesis) and...
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Renin Angiotensin System and Thyroid Hormone Crosstalk: From Experimental Approaches to Clinical Perspectives
The renin angiotensin systemRenin angiotensin system (RAS) plays a central role in the maintenance of regular cardiovascular functions and is...
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Crucial Metabolic Networks: Cancer Progression
The study of metabolic networks in cancer cells is essential for understanding the fundamental properties of living systems and how metabolic...
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Mechanistic Implications of GSK and CREB Crosstalk in Ischemia Injury
Ischemia-reperfusion (IR) injury is a damage to an organ when the blood supply is less than the demand required for normal functioning, leading to...
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The Metabolic Landscape of Breast Cancer and Its Therapeutic Implications
Breast cancer is the most common malignant tumor globally as of 2020 and remains the second leading cause of cancer-related death among female...
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SLC27A2 mediates FAO in colorectal cancer through nongenic crosstalk regulation of the PPARs pathway
BackgroundPeroxisome proliferator activated receptors ( PPARs ) are a nuclear hormone receptors superfamily that is closely related to fatty acid (FA)...
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Competing Endogenous RNAs Crosstalk in Hippocampus: A Potential Mechanism for Neuronal Develo** Defects in Down Syndrome
Down syndrome (DS) is the most example of aneuploidy, resulting from an additional copy of all or part of chromosome 21. Competing endogenous RNAs...
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Systemic Onco-Sphere: Host Metabolic System and Cancer
It is well established that patients with altered metabolism manifesting as obesity, metabolic syndrome and chronic inflammation have an increased...
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Insight into the Physiological and Molecular Crosstalk During Bacterial-Fungal Interactions
Purpose of ReviewBacterial-fungal interaction (BFI) is a complex biological crosstalk that influences the ecological processes in the field of...
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Gut microbiota-bile acid crosstalk regulates murine lipid metabolism via the intestinal FXR-FGF19 axis in diet-induced humanized dyslipidemia
BackgroundDiet-induced dyslipidemia is linked to the gut microbiota, but the causality of microbiota-host interaction affecting lipid metabolism...
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Immune Compartments and Extracellular Matrix Crosstalk Involved in Tumor Dissemination
Numerous precedents indicate that the immune system plays a dual role in preventing or allowing tumor development, progression, and dissemination....
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A novel CAF-cancer cell crosstalk-related gene prognostic index based on machine learning: prognostic significance and prediction of therapeutic response in head and neck squamous cell carcinoma
BackgroundCancer-associated fibroblast (CAF)-cancer cell crosstalk (CCCT) plays an important role in tumor microenvironment sha** and immunotherapy...
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Metabolic adaptations in prostate cancer
Prostate cancer is one of the most commonly diagnosed cancers in men and is a major cause of cancer-related deaths worldwide. Among the molecular...
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The multifaceted role of extracellular vesicles (EVs) in colorectal cancer: metastasis, immune suppression, therapy resistance, and autophagy crosstalk
Extracellular vesicles (EVs) are lipid bilayer structures released by all cells and widely distributed in all biological fluids. EVs are implicated...
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Crosstalk Between Matrix Metalloproteinases and Their Inducer EMMPRIN/CD147: a Promising Therapeutic Target for Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is characterized by the disruption of cerebrovascular integrity, resulting in hematoma enlargement, edema formation,...
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Realgar-Induced Neurotoxicity: Crosstalk Between the Autophagic Flux and the p62-NRF2 Feedback Loop Mediates p62 Accumulation to Promote Apoptosis
Realgar is a traditional Chinese medicine that contains arsenic. It has been reported that the abuse of medicine-containing realgar has potential...
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HIF2α, Hepcidin and their crosstalk as tumour-promoting signalling
Not all aspects of the disruption of iron homeostasis in cancer have been fully elucidated. Iron accumulation in cancer cells is frequent for many...
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The role of exosome derived miRNAs in inter-cell crosstalk among insulin-related organs in type 2 diabetes mellitus
Exosomes are small extracellular vesicles secreted by almost all cell types, and carry diverse cargo including RNA, and other substances. Recent...
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Low-density lipoprotein receptor promotes crosstalk between cell stemness and tumor immune microenvironment in breast cancer: a large data-based multi-omics study
BackgroundTumor cells with stemness in breast cancer might facilitate the immune microenvironment’s suppression process and led to anti-tumor immune...
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Multi-omics data reveals the important role of glycerophospholipid metabolism in the crosstalk between gut and brain in depression
BackgroundGut microbiota plays a critical role in the onset and development of depression, but the underlying molecular mechanisms are unclear. This...
