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Zebrafish Models for Screening of Metabolic Diseases
Metabolic diseases such as type 2 diabetes, coronary heart disease, and obesity are the leading cause of morbidity and mortality. In the drug...
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Prostate cancer in transgender women: considerations for screening, diagnosis and management
Transgender individuals represent 0.55% of the US population, equivalent to 1.4 million transgender adults. In transgender women, feminisation can...
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A cost-effectiveness analysis of lung cancer screening with low-dose computed tomography and a polygenic risk score
IntroductionSeveral studies have proved that Polygenic Risk Score (PRS) is a potential candidate for realizing precision screening. The effectiveness...
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Screening of small molecule compounds targeting hnRNPA2 protein
Heterogeneous nuclear ribonucleoprotein A2, as an RNA binding protein, participates in the processing and metabolism of RNA molecules. HnRNPA2 is...
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Colorectal cancer screening: results from the World Trade Center Health Registry cohort
PurposeLittle is known about colorectal cancer screening in 9/11 World Trade Center (WTC)-exposed populations. We utilized survey data from the WTC...
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Adolescents’ experiences and views of the national school-based thalassaemia screening programme in Malaysia: a qualitative study
In 2016, a national school-based thalassemia screening programme was implemented in Malaysia. This study aimed to explore the experiences and views...
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Bladder cancer: therapeutic challenges and role of 3D cell culture systems in the screening of novel cancer therapeutics
Bladder cancer (BC) is the sixth most common worldwide urologic malignancy associated with elevated morbidity and mortality rates if not well...
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Mass spectrometric profiling of tryptic digests of trifluoroethanol extracts from core needle biopsies of breast cancer tissues is a viable sample screening tool for biomarker discovery
Application of classifying limited sampling biopsies by matrix-assisted laser desorption/ionization time-of-flight (MALDI-ToF) based mass spectral...
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A Method for the In Vitro Cytotoxicity Assessment of Anti-cancer Compounds and Materials Using High Content Screening Analysis
To date, there is a large bottleneck associated with cancer drug design and development: a lack of appropriate methodologies for screening their...
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Body mass index–based predictions and personalized clinical strategies for colorectal cancer in the context of PPPM
Currently colorectal cancer (CRC) is the third most prevalent cancer worldwide. Body mass index (BMI) is frequently used in CRC screening and risk...
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Perception of genomic newborn screening among peripartum mothers
Advances in genomic technology have generated possibilities for expanding newborn screening from traditional procedures to genomic newborn screening...
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Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers
BackgroundPatient-derived glioma stem-like cells (GSCs) have become the gold-standard in neuro-oncological research; however, it remains to be...
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Squamous Cell Carcinoma Predisposition Pathophysiology, Diagnosis, and Treatment
Squamous Cell Carcinoma (SCC) is a prevalent form of skin and oral cancer, characterized by the uncontrolled growth of abnormal squamous cells in the...
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Peptide-encoding mRNA barcodes for the high-throughput in vivo screening of libraries of lipid nanoparticles for mRNA delivery
Develo** safe and effective nanoparticles for the delivery of messenger RNA (mRNA) is slow and expensive, partly due to the lack of predictive...
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Exhaled VOC detection in lung cancer screening: a comprehensive meta-analysis
BackgroundLung cancer (LC), characterized by high incidence and mortality rates, presents a significant challenge in oncology. Despite advancements...
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A cost-benefit analysis of genetic screening test for breast cancer in Iran
BackgroundThis study aimed to evaluate the implementation of the population- and family history (FH) -based screening for BReast CAncer (BRCA) in...
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Mass testing and treatment for malaria followed by weekly fever screening, testing and treatment in Northern Senegal: feasibility, cost and impact
BackgroundPopulation-wide interventions using malaria testing and treatment might decrease the reservoir of Plasmodium falciparum infection and...
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Cystic and Alveolar Echinococcosis: Fraternal Twins Both in Search of Optimal Treatment
The burden of the two different diseases, “cystic echinococcosis” (CE), due to several species of Echinococcus among the E. granulosus sensu lato...
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Breast Cancer: Epidemiology, Types, Diagnosis, and Treatment
Breast cancer is a complex disease, and many aspects of this disease are under intensive research. Better treatment of breast cancer can only be...
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Sociodemographic characteristics, attitudes, and knowledge associated with previous screening for cervical cancer among women in western Jamaica
BackgroundAbout 90% of new cervical cancer cases and deaths worldwide in 2020 occurred in low- and middle-income countries. This can be attributed to...
