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COVID-19 vaccination induces distinct T-cell responses in pediatric solid organ transplant recipients and immunocompetent children
Immune responses to COVID-19 vaccination are attenuated in adult solid organ transplant recipients (SOTRs) and additional vaccine doses are...
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Ultrasound-mediated multifunctional magnetic microbubbles for drug delivery of celastrol in VX2 liver transplant tumors
Celastrol (CST) has positive pharmacological effects on various cancers, but clinical application is limited because of poor water solubility and...
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Assessment of an exhaled breath test using ultraviolet photoionization time-of-flight mass spectrometry for the monitoring of kidney transplant recipients
Continuous monitoring for immunosuppressive status, infection and complications are a must for kidney transplantation (KTx) recipients. Traditional...
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Donor Recipient Chimeric Cells Induce Chimerism and Extend Survival of Vascularized Composite Allografts
This study evaluated the efficacy of donor recipient chimeric cell (DRCC) therapy created by fusion of donor and recipient derived bone marrow cells...
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Association between fibrosis-related gene polymorphism and long-term allograft outcome in renal transplant recipients
BackgroundRenal allograft fibrosis is one of characteristic causes of long-term renal function loss. The purpose of our study is to investigate the...
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Liver Cancer: Interdisciplinary Approach
Liver cancer is currently the fifth most common malignant tumor and the second leading cause of tumor deaths. Its pathogenesis is extremely complex,...
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Comparable anti-CMV responses of transplant donor and third-party CMV-specific T cells for treatment of CMV infection after allogeneic stem cell transplantation
Adoptive transfer of cytomegalovirus (CMV)-specific cytotoxic T lymphocytes (CMV-CTLs) from original transplant donors or third-party donors was...
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The potential liver injury induced by metronidazole-provoked disturbance of gut microbiota: modulatory effect of turmeric supplementation
It has been reported that the gut-liver axis and intestinal microbiome contribute crucially to different liver diseases. So, targeting this...
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Effects of Chemotherapy on Neuroinflammation, Neuronal Damage, Neurogenesis, and Behavioral Performance in Bone Marrow Transplantation Recipient Mice
As bone marrow transplant (BMT) is gradually applied to the study of central nervous system (CNS) disease, it is needed to investigate the proper...
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SARS-CoV-2 BA.2 (Omicron) variant infection in pediatric liver transplanted recipients and cohabitants during 2022 Shanghai outbreak: a prospective cohort
BackgroundThe Omicron variant BA.2 was the dominant variant in the COVID-19 outbreak in Shanghai since March 2022. We aim to investigate the...
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Gene Therapy in Liver Disease: Challenges and Outcomes
Liver-directed gene therapy (LDGT) has been proposed as a means of treating many single-gene inherited disorders. LDGT has been used to create...
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When to call it off: defining transplant candidacy limits in liver donor liver transplantation for hepatocellular carcinoma
BackgroundLiving donor liver transplantation (LDLT) is an acceptable treatment option for hepatocellular carcinoma (HCC). Traditional transplant...
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Revisiting transplant immunology through the lens of single-cell technologies
Solid organ transplantation (SOT) is the standard of care for end-stage organ disease. The most frequent complication of SOT involves allograft...
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Complement networks in gene-edited pig xenotransplantation: enhancing transplant success and addressing organ shortage
The shortage of organs for transplantation emphasizes the urgent need for alternative solutions. Xenotransplantation has emerged as a promising...
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Domino hepatocyte transplantation using explanted human livers with metabolic defects attenuates D-GalN/LPS-induced acute liver failure
BackgroundExplanted livers from patients with inherited metabolic liver diseases possess the potential to be a cell source of good-quality...
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Body composition is associated with tacrolimus pharmacokinetics in kidney transplant recipients
PurposeA population pharmacokinetic (popPK) model may be used to improve tacrolimus dosing and minimize under- and overexposure in kidney transplant...
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Risk factors and molecular epidemiology of fecal carriage of carbapenem resistant Enterobacteriaceae in patients with liver disease
BackgroundCarbapenem resistant Enterobacteriaceae (CRE) colonization is a risk factor for CRE infection. CRE infection results in an increase in...
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Impact of chronic graft-versus-host disease on quality of life and cognitive function of long-term transplant survivors after allogeneic hematopoietic stem cell transplantation with total body irradiation
BackgroundTotal body irradiation (TBI)-based-conditioning before allogeneic hematopoietic stem cell transplantation (allo-HSCT) is standard of care...
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Scalable production of tissue-like vascularized liver organoids from human PSCs
The lack of physiological parity between 2D cell culture and in vivo culture has led to the development of more organotypic models, such as...
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Cost-effectiveness analysis of CYP3A5 genotype-guided tacrolimus dosing in solid organ transplantation using real-world data
The objective of this study was to estimate the cost-effectiveness of CYP3A5 genotype-guided tacrolimus dosing in kidney, liver, heart, and lung...
