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Antitumor Effect of Traditional Drugs for Neurological Disorders: Preliminary Studies in Neural Tumor Cell Lines
Glioblastoma multiforme is the most common malignant primary brain tumor in adults. Despite new treatments developed including immunomodulation using...
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Biallelic variants in the synaptic vesicle glycoprotein 2 A are associated with epileptic encephalopathy
Synaptic Vesicle Glycoprotein 2 A (SV2A) is a membrane protein of synaptic vesicles and the binding site of antiepileptic drug levetiracetam....
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Screening oral drugs for their interactions with the intestinal transportome via porcine tissue explants and machine learning
In vitro systems that accurately model in vivo conditions in the gastrointestinal tract may aid the development of oral drugs with greater...
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Levetiracetam as preventive treatment in adults with migraine: an up-to-date systematic review and quantitative meta-analysis
PurposeThe aim of this systematic review was to evaluate current evidence on the efficacy and safety of levetiracetam as migraine prophylaxis in...
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Efficacy of levetiracetam as first-line therapy for neonatal clinical seizures and neurodevelopmental outcome at 12 months of age
Appropriate treatment of neonatal seizures with an effective therapy is important in reducing long-term neurologic disabilities. Sixty-seven...
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Genotype-phenotype correlations of STXBP1 pathogenic variants and the treatment choices for STXBP1-related disorders in China
BackgroundWe aimed to analyze the genotype-phenotype correlations of STXBP1 pathogenic variants, prognostic factors and the treatment choices in a...
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Pathophysiological basis and promise of experimental therapies for Gulf War Illness, a chronic neuropsychiatric syndrome in veterans
This article describes the pathophysiology and potential treatments for Gulf War Illness (GWI), which is a chronic neuropsychiatric illness linked to...
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Methodological and analytical considerations for intra-operative microdialysis
BackgroundMicrodialysis is a technique that can be utilized to sample the interstitial fluid of the central nervous system (CNS), including in...
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Development and Use of an Ex-Vivo In-Vivo Correlation to Predict Antiepileptic Drug Clearance in Patients Undergoing Continuous Renal Replacement Therapy
ObjectivesResults from previous ex-vivo continuous renal replacement therapy (CRRT) models have successfully demonstrated similar extraction...
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The Protective Effects of Levetiracetam on a Human iPSCs-Derived Spinal Muscular Atrophy Model
Spinal muscular atrophy (SMA) is an inherited disease characterized by progressive motor neuron death and subsequent muscle weakness and is caused by...
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Drug Dosing in Critically Ill Adult Patients with Augmented Renal Clearance
Augmented renal clearance (ARC) is a phenomenon of enhanced renal function seen in critically ill patients. ARC alters the disposition of renally...
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Acute on chronic cervical myelopathy causing cervical segmental myoclonus in a high-level wheelchair athlete: a case report
IntroductionThis is a 20-year-old wheelchair athlete with history of caudal regression syndrome and cervical canal stenosis who developed spinal...
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Pharmacologic therapies of pain in patients with spinal cord injury: a systematic review
Study designSystematic review.
ObjectivesThis systematic review evaluates all randomized clinical trials (RCTs) conducted on assessing the efficacy...
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Expression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE)
Synaptic vesicle glycoprotein-2 (SV2) is a family of proteins consisting of SV2A, SV2B, and SV2C. This protein family has attracted attention in...
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Age-Dependent Phenomena of 6-Hz Corneal Kindling Model in Mice
Although numerous studies have acknowledged disparities in epilepsy-related disease processes between young and aged animals, little is known about...
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Aquaporin 4 in Traumatic Brain Injury: From Molecular Pathways to Therapeutic Target
Traumatic brain injury (TBI) is known as an acute degenerative pathology of the central nervous system, and has been shown to increase brain...
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Cerebral malaria presenting as nonconvulsive status epilepticus: a case report
BackgroundMalaria is an infectious malady caused by Plasmodium parasites, cerebral malaria standing out as one of its most severe complications....
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Recent Advances in the Applications of Additive Manufacturing (3D Printing) in Drug Delivery: A Comprehensive Review
There has been a tremendous increase in the investigations of three-dimensional (3D) printing for biomedical and pharmaceutical applications, and...
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Computer-Assisted Manufacturing of Medicines
Computer-aided manufacturing (CAM), in the twenty-first century, is the automated manufacturing process that works in line with computer-assisted...