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Mitochondrial DNA-triggered innate immune response: mechanisms and diseases
Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from mitochondria into the cytosol. The released mtDNA is sensed by the...
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Redox regulation of the immune response
The immune-inflammatory response is associated with increased nitro-oxidative stress. The aim of this mechanistic review is to examine: (a) the role...
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Identification immune response genes in psoriasis after treatment with secukinumab
BackgroundSecukinumab is a fully human IgG1κ MoAb that selectively binds to IL-17A with high affinity, and it has been proven effective for the...
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Analysis of the Immune Response by Standardized Whole-Blood Stimulation with Metabolism Modulation
The immune system defends the body from infection and plays a vital role in a wide range of health conditions. Metabolism affects a series of...
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Phosphoflow cytometry to assess cytokine signaling pathways in peripheral immune cells: potential for inferring immune cell function and treatment response in patients with solid tumors
Tumor biopsy is often not available or difficult to obtain in patients with solid tumors. Investigation of the peripheral immune system allows for...
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Dissecting the tumor microenvironment in response to immune checkpoint inhibitors via single-cell and spatial transcriptomics
Cancer is a disease that undergoes selective pressure to evolve during its progression, becoming increasingly heterogeneous. Tumoral heterogeneity...
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Central nervous system-associated macrophages modulate the immune response following stroke in aged mice
Age is a major nonmodifiable risk factor for ischemic stroke. Central nervous system-associated macrophages (CAMs) are resident immune cells located...
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The Adaptive Defense Response: Physiological and Pathological Stimulatory Potential of Food Components in the Antigen-Specific Immune Response
Upon prolonged immunogenic stimulation, an antigen-specific adaptive defense response is initiated. The established signaling of the innate defense...
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Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment
A highly immunosuppressive tumor microenvironment (TME) and the presence of the blood‒brain barrier are the two major obstacles to eliciting an...
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Conserved methylation signatures associate with the tumor immune microenvironment and immunotherapy response
BackgroundAberrant DNA methylation is a major characteristic of cancer genomes. It remains unclear which biological processes determine epigenetic...
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Emerging Targets for Modulation of Immune Response and Inflammation in Stroke
The inflammatory and immunological responses play a significant role after stroke. The innate immune activation stimulated by microglia during stroke...
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Control of immune cell function by the unfolded protein response
Initiating and maintaining optimal immune responses requires high levels of protein synthesis, folding, modification and trafficking in leukocytes,...
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Role of Monocyte-Derived Dendritic Cells (MoDCs) in Tumor Immune Response
Dendritic cells (DCs) have the ability to elicit long-lasting antitumor immune responses. The immune system’s ability to produce an efficient...
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Food and the Immune System Molecular Mechanisms and Nutritional Relevance in Health and Disease
Nutrition is an important environmental factor for the maturation of the human immune system and essential for maintaining immunological homeostasis....
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Natural Human Immune Response Identifies An Unnatural Oncology Target for Immunotherapy
The intelligence of the natural human immune response can be exploited to recognize antigenic targets useful in oncology. A component of this...
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Peripheral inflammatory immune response differs among sporadic and familial Parkinson’s disease
Peripheral inflammatory immune responses are thought to play a major role in the pathogenesis of Parkinson’s disease (PD). The...
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Map** interindividual dynamics of innate immune response at single-cell resolution
Common genetic variants across individuals modulate the cellular response to pathogens and are implicated in diverse immune pathologies, yet how they...
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Humoral immune response and safety of Sars-Cov-2 vaccine in people with multiple sclerosis
BackgroundFor the past three years, the pandemic has had a major effect on global public health, mainly on those with underlying medical conditions,...
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Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies
The disease-specific accumulation of pathological proteins has long been the major focus of research in neurodegenerative diseases (ND), including...
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Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen
Pain involves neuroimmune crosstalk, but the mechanisms of this remain unclear. Here we showed that the splenic T helper 2 (T H 2) immune cell response...
