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Long-Lasting Stretching Induces Muscle Hypertrophy: A Meta-Analysis of Animal Studies
Muscular hypertrophy depends on metabolic exhaustion as well as mechanical load on the muscle. Mechanical tension seems to be the crucial factor to...
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GDH promotes isoprenaline-induced cardiac hypertrophy by activating mTOR signaling via elevation of α-ketoglutarate level
Numerous studies reveal that metabolism dysfunction contributes to the development of pathological cardiac hypertrophy. While the abnormal lipid and...
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Nitidine chloride induces cardiac hypertrophy in mice by targeting autophagy-related 4B cysteine peptidase
Nitidine chloride (NC) is a standard active component from the traditional Chinese medicine Zanthoxylum nitidum (Roxb.) DC. (ZN). NC has shown a...
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Predictors of muscle hypertrophy responsiveness to electrically evoked resistance training after spinal cord injury
The purpose of the study was to identify potential predictors of muscle hypertrophy responsiveness following neuromuscular electrical stimulation...
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Soluble factors in COVID-19 mRNA vaccine-induced myocarditis causes cardiomyoblast hypertrophy and cell injury: a case report
BackgroundInflammation affecting the heart and surrounding tissues is a clinical condition recently reported following COVID-19 mRNA vaccination....
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Comparison of the effects of long-lasting static stretching and hypertrophy training on maximal strength, muscle thickness and flexibility in the plantar flexors
Maximal strength measured via maximal voluntary contraction is known as a key factor in competitive sports performance as well as injury risk...
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SZC-6, a small-molecule activator of SIRT3, attenuates cardiac hypertrophy in mice
Sirtuin3 (SIRT3), a class III histone deacetylase, is implicated in various cardiovascular diseases as a novel therapeutic target. SIRT3 has been...
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S-nitrosylation of Hsp90 promotes cardiac hypertrophy in mice through GSK3β signaling
Cardiac hypertrophy, as one of the major predisposing factors for chronic heart failure, lacks effective interventions. Exploring the pathogenesis of...
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Genome Editing and Pathological Cardiac Hypertrophy
Three major genome editing tools, transcription activator-like effector nucleases (TALENs), zinc finger nucleases (ZFNs), and clustered regularly...
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Activation of the endocannabinoid system mediates cardiac hypertrophy induced by rosiglitazone
Rosiglitazone (RSG) is a synthetic agonist of peroxisome proliferator-activated receptor-γ (PPARγ), which plays a central role in the regulation of...
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Quercetin: A Promising Flavonoid for the Therapy of Cardiac Hypertrophy and Heart Failure Mediated by the Renin Angiotensin System
The Renin angiotensin systemRenin angiotensin system (RAS) plays an essential role in regulating the angiotensin IIAngiotensin II levels in the body...
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Lupeol protects against cardiac hypertrophy via TLR4-PI3K-Akt-NF-κB pathways
Inflammation and apoptosis are main pathological processes that lead to the development of cardiac hypertrophy. Lupeol, a natural triterpenoid, has...
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The role of the neural stimulus in regulating skeletal muscle hypertrophy
Resistance training is frequently performed with the goal of stimulating muscle hypertrophy. Due to the key roles motor unit recruitment and...
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TCF7/SNAI2/miR-4306 feedback loop promotes hypertrophy of ligamentum flavum
BackgroundHypertrophy of ligamentum flavum (HLF) is the mainly cause of lumbar spinal stenosis (LSS), but the precise mechanism of HLF formation has...
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Relationship between hypertrophy, strength gains and tensiomyography adaptations: a moderator role of contraction duration
The aim of the study was to investigate how the relationship between resistance training-induced hypertrophy, strength, and passive contractile...
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Calorie restriction changes lipidomic profiles and maintains mitochondrial function and redox balance during isoproterenol-induced cardiac hypertrophy
Typically, healthy cardiac tissue utilizes more fat than any other organ. Cardiac hypertrophy induces a metabolic shift leading to a preferential...
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Indoxyl Sulfate Activates NLRP3 Inflammasome to Induce Cardiac Contractile Dysfunction Accompanied by Myocardial Fibrosis and Hypertrophy
In patients with chronic kidney diseases (CKD), high serum indoxyl sulfate (IS) levels correlate with cardiac fibrosis and hypertrophy and thus a...
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RNA-binding protein CELF1 promotes cardiac hypertrophy via interaction with PEBP1 in cardiomyocytes
Cardiac hypertrophy is considered as a common pathophysiological process in various cardiovascular diseases. CUG triplet repeat-binding protein 1...
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Effects of transdermal estrogen therapy on satellite cell number and molecular markers for muscle hypertrophy in response to resistance training in early postmenopausal women
PurposeTo investigate the effects of resistance training with or without transdermal estrogen therapy (ET) on satellite cell (SC) number and...
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Clusterin negatively modulates mechanical stress-mediated ligamentum flavum hypertrophy through TGF-β1 signaling
Ligamentum flavum hypertrophy (LFH) is a major cause of lumbar spinal canal stenosis (LSCS). The pathomechanisms for LFH have not been fully...
