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Contribution of systemic vascular reactivity to variability in pulse volume amplitude response during reactive hyperemia
PurposeThe aim of the present study was to investigate why the magnitude of reactive hyperemia (RH) observed by pulse volume amplitude (PVA) after...
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Intratesticular versus intraperitoneal injection of Busulfan for the induction of azoospermia in a rat model
BackgroundAdministration of antineoplastic drugs may cause azoospermia driving to subfertility. Production of animal azoospermia models is essential...
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The effect of four weeks blood flow restricted resistance training on macro- and micro-vascular function in healthy, young men
PurposeTo determine the macrovascular and microvascular function responses to resistance training with blood flow restriction (BFR) compared to...
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The impact of repeated, local heating-induced increases in blood flow on lower limb endothelial function in young, healthy females
PurposeThe purpose of the present study was to examine the effect of repeated, single leg heating on lower limb endothelial function.
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A case report on a novel use of intraoperative Intrabeam™ radiation therapy for a recurrent malignant peripheral nerve sheath tumor with sciatic nerve involvement
BackgroundMalignant peripheral nerve sheath tumors (MPNST) are sarcomas that arise from peripheral nerves. They generally have a poor prognosis which...
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KATP channels and NO dilate redundantly intramuscular arterioles during electrical stimulation of the skeletal muscle in mice
Functional hyperemia is fundamental to provide enhanced oxygen delivery during exercise in skeletal muscle. Different mechanisms are suggested to...
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Comparison of ephedrine and pseudoephedrine contents in 34 Kampo extracts containing Ephedrae Herba used clinically in Japan
Ephedrae Herba is among the important crude drugs prescribed in Kampo medicine for the treatment of cold, flue, rhinitis, nasal congestion, cough,...
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The incidence of obesity, venous sinus stenosis and cerebral hyperaemia in children referred for MRI to rule out idiopathic intracranial hypertension at a tertiary referral hospital: a 10 year review
BackgroundChildren referred to a tertiary hospital for the indication, “rule out idiopathic intracranial hypertension (IIH)” may have an increased...
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Evidence of premature vascular dysfunction in young adults who regularly use e-cigarettes and the impact of usage length
BackgroundElectronic (e-) cigarettes are increasingly popular tobacco products on the US market. Traditional tobacco products are known to cause...
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Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension
Hypertension (HTN), a disease afflicting over one billion individuals worldwide, is a leading cause of cognitive impairment, the mechanisms of which...
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Measures of Endothelial Function in Type 2 Diabetes: A Focus on Non-circulatory Methods of Measurement
The endothelium is a vital organ important for regulating vascular homeostasis. Endothelial dysfunction in type 2 diabetes has been linked to the...
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Central and peripheral haemodynamics at exercise onset: the role of central command
PurposeThe involvement of central command in central hemodynamic regulation during exercise is relatively well-known, although its contribution to...
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Synaptic-like transmission between neural axons and arteriolar smooth muscle cells drives cerebral neurovascular coupling
Neurovascular coupling (NVC) is important for brain function and its dysfunction underlies many neuropathologies. Although cell-type specificity has...
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Formulation, Development, and Comparative Study of Azelastine-Loaded Temperature Sensitive In Situ Gelling Micelles for Allergic Conjunctivitis
PurposeThe current investigative study was performed to analyze and compare the effect of gellan gum-mixed poloxamer 407 as compared to plain...
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Hesperidin counteracts chlorpyrifos-induced neurotoxicity by regulating oxidative stress, inflammation, and apoptosis in rats
Chlorpyrifos (CPF), considered one of the most potent organophosphates, causes a variety of human disorders including neurotoxicity. The current...
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Ocular Pharmacokinetic and Safety Studies
Ocular pharmacokinetic (PK) and safety studies in animals are essential components in the drug development pipeline. Ocular PK studies are designed...
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Energy availability modulates regional blood flow via estrogen-independent pathways in regularly menstruating young women
PurposeThis study aimed to investigate the impact of short-term low energy availability (LEA) on vascular function in young, regularly menstruating...
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Baccharis trimera (carqueja) promotes gastroprotection on ethanol-induced acute gastric ulcer
One of the factors that can promote gastric ulcer is the acute and/or chronic consumption of ethanol. One of the most used therapeutic measures is...
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Aurantio-obtusin Alleviates Dry Eye Disease by Targeting NF-κB/NLRP3 Signaling in Rodent Models
Dry eye disease (DED) is a common inflammatory ocular surface disorder, seriously affecting the quality of life of patients. Aurantio-obtusin (AO) is...
