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Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF
The cross-talk between thymocytes and thymic stromal cells is fundamental for T cell development. In humans, intrathymic development of dendritic...
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Interpreting non-coding disease-associated human variants using single-cell epigenomics
Genome-wide association studies (GWAS) have linked hundreds of thousands of sequence variants in the human genome to common traits and diseases....
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Profiling Cell Type-Specific Gene Regulatory Regions in Human Cortical Organoids
Dissecting the molecular heterogeneity of the develo** human brain is a long-standing ambition of neuroscientists. This has become both a practical...
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Liposomal Formulation Reduces Transport and Cell Uptake of Colistin in Human Lung Epithelial Calu-3 Cell and 3D Human Lung Primary Tissue Models
Respiratory tract infections caused by multi-drug-resistant (MDR) bacteria have been a severe risk to human health. Colistin is often used to treat...
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Phenotypic and Functional Studies of Human Treg Cell Subpopulations
CD4+ regulatory T (Treg) cells play an important role in maintaining immune homeostasis. Although these cells were initially studied as a homogenous...
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ATF4 renders human T-cell acute lymphoblastic leukemia cell resistance to FGFR1 inhibitors through amino acid metabolic reprogramming
Abnormalities of FGFR1 have been reported in multiple malignancies, suggesting FGFR1 as a potential target for precision treatment, but drug...
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Per-cell histone acetylation is associated with terminal differentiation in human T cells
BackgroundEpigenetic remodeling at effector gene loci has been reported to be critical in regulating T cell differentiation and function. However,...
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An atlas of cell-type-specific interactome networks across 44 human tumor types
BackgroundBiological processes are controlled by groups of genes acting in concert. Investigating gene–gene interactions within different cell types...
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Analysis of REST binding sites with canonical and non-canonical motifs in human cell lines
BackgroundRepressor element 1 (RE1) silencing transcription factor (REST) is a transcriptional repressor abundantly expressed in aging human brains....
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Exploring Heparan Sulfate Proteoglycans as Mediators of Human Mesenchymal Stem Cell Neurogenesis
Alzheimer’s disease (AD) and traumatic brain injury (TBI) are major public health issues worldwide, with over 38 million people living with AD and...
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Single-cell long-read sequencing-based map** reveals specialized splicing patterns in develo** and adult mouse and human brain
RNA isoforms influence cell identity and function. However, a comprehensive brain isoform map was lacking. We analyze single-cell RNA isoforms across...
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CD8 cytotoxic T-cell infiltrates and cellular damage in the hypothalamus in human obesity
Rare cases of paraneoplastic obesity in children suggest sporadic obesity might also arise from an adaptive immune cell-mediated mechanism. Since the...
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Generating Human Pluripotent Stem Cell-Derived Neural AssemBloids™ to Model Interneuron Migration and Immune Cell Interactions
Three-dimensional (3D) brain organoids derived from human pluripotent stem cells (hPSCs) have emerged as an innovative model to study the central...
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Studying the Proliferative Activity of Human Corneal Stromal Cell Populations
The proliferative activity of populations of stromal cells (fibroblasts) obtained from human corneal lenticles under conditions of their...
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Micromanipulator-Assisted Subretinal Transplantation of Human Photoreceptor Reporter Cell Suspensions into Mice
Retinopathies marked by photoreceptor cell loss are the main cause of visual impairment and blindness in industrialized societies. Photoreceptor...
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Functional genomics of human clear cell sarcoma: genomic, transcriptomic and chemical biology landscape for clear cell sarcoma
BackgroundSystemic therapy for metastatic clear cell sarcoma (CCS) bearing EWSR1-CREB1/ATF1 fusions remains an unmet clinical need in children,...
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How mechanisms of stem cell polarity shape the human cerebral cortex
Apical–basal progenitor cell polarity establishes key features of the radial and laminar architecture of the develo** human cortex. The unique...
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Single-cell atlases: shared and tissue-specific cell types across human organs
The development of single-cell and spatial transcriptomics methods was instrumental in the conception of the Human Cell Atlas initiative, which aims...
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A single-cell atlas enables map** of homeostatic cellular shifts in the adult human breast
Here we use single-cell RNA sequencing to compile a human breast cell atlas assembled from 55 donors that had undergone reduction mammoplasties or...
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The effect of T cell aging on the change of human tissue structure
The trend of aging of the global population is becoming more and more significant, and the incidence of age-related diseases continues to rise.This...